Clinical trials: Adverse Respiratory Events
Pain, Quality of Life
Simultaneous RZV and aIIV4 Vaccination
The overall aim of the study is to compare the safety of simultaneous Zoster Vaccine Recombinant, Adjuvanted (RZV) (SHINGRIX®) and Quadrivalent Influenza Vaccine, Adjuvanted (FLUAD®) versus simultaneous Zoster Vaccine…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05007041
- Testing
- FLUAD® Quadrivalent, Fluzone® High-Dose Quadrivalent, SHINGRIX®
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Duke University
Covid-19
Predict Adverse Events by Covid-19 Nephritis
This non-interventional, observational study retrospectively (and in parts prospectively) investigates, if a Covid-19 associated Nephritis, diagnosed by Urine-dipstick and further Urine-analyses on addmission, can help to predict…
- Trial name
- NCT04347824
- Where
- Germany
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- University Hospital Goettingen
Vaccine Adverse Reaction, COVID-19
Immunization of 7 Different Vaccines Against SARS-COV-2 Across 4 Countries.
Background: Scarce information exists in relation to the comparison of seroconversion and adverse events following immunization (AEFI) with different SARS-COV2 vaccines.
- Conditions
- Vaccine Adverse Reaction, COVID-19, Vaccine Reaction
- Trial name
- NCT05228912
- Testing
- COVID-19 Vaccines
- Where
- Mexico
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- Hospital Clinica Nova
COVID-19
Incidence of COVID-19 Following Vaccination in Botswana Against SARS CoV 2
The AstraZeneca Study is a single-arm, open-label, interventional, Phase 3b study to determine the incidence of laboratory-confirmed COVID-19 hospitalizations, disease severity, and deaths and attributable adverse events (AEs) in…
- Trial name
- NCT05715944
- Testing
- AZD 1222
- Where
- Botswana
- Volunteers
- 10,888 people, healthy volunteers welcome
- Sponsor
- Botswana Harvard AIDS Institute Partnership
Influenza, Vaccines Adverse Reaction
Surveillance for Adverse Events Following Influenza Immunization
Influenza vaccines are continuously modified to adjust to the virus antigenic shifts or drifts, and its safety profile may vary.
- Trial name
- NCT01318876
- Where
- 7 sites in Canada
- Volunteers
- 7,645 people, healthy volunteers welcome
- Sponsor
- PHAC/CIHR Influenza Research Network
Safety, Adverse Event Following Immunisation
Safety of RIV4 Versus IIV4 in Pregnant Women
This is a prospective, randomized clinical trial. During the study, pregnant women will be randomized (1:1) to receive RIV4 or IIV4. Vaccines will be administered by licensed providers.
- Conditions
- Safety, Adverse Event Following Immunisation, Birth Outcomes
- Trial name
- NCT03969641
- Testing
- Quadrivalent Recombinant Influenza Vaccine, Quadrivalent Inactivated Influenza Vaccine
- Where
- 3 sites in United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Duke University
Streptococcal Pneumonia, Nasopharyngeal Diseases
PCV7 in the Prevention of Nasopharyngeal Carriage of Vaccine Serotype (VT) Streptococcus Pneumoniae
A parallel-group, randomized, open-label study will be performed in subjects receiving PCV7 and subjects receiving controlled vaccine Hib vaccine, to claim the efficacy of PCV7 in the prevention of NP carriage of vaccine-serotype…
- Conditions
- Streptococcal Pneumonia, Nasopharyngeal Diseases, Vaccination Adverse Event
- Trial name
- NCT02133469
- Testing
- PCV7 (Pneumococcal 7-Valent Conjugate Vaccine), Hib Vaccine
- Where
- 9 sites in China
- Volunteers
- 3,281 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Healthy Volunteers
Study to Assess Adverse Events and How Oral ABBV-990 Moves Through the Body of Adult Healthy Participants
This study will assess how safe ABBV-990 is and how ABBV-990 moves through the body of adult healthy participants. Adverse Events will be assessed.
- Trial name
- NCT05475821
- Testing
- ABBV-990
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AbbVie
Allergic Rhinitis, Adverse Drug Event
Efficacy and Adverse Effects of Prapchompoothaweep Remedy and Loratadine for Treatment in AR Patients
1. To compare the effectiveness of Prapchompoothaweep crude drug at 3,000 mg per day and Loratadine 10 mg per day for treatment in Allergic Rhinitis patients. (Clinical Trial Phase II) 2.
- Conditions
- Allergic Rhinitis, Adverse Drug Event, Quality of Life
- Trial name
- NCT03640273
- Testing
- Prapchompoothaweep remedy, Loratadine 10 Mg
- Where
- Thailand
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Influenza, Vaccination Adverse Event
A Post-marketing Safety Study of Inactivated, Split-virion Influenza Vaccine in Subjects Aged 3 Years and Older
To monitor the safety of Shanghai Institute of Biological Products Company's influenza vaccine in subjects aged 3 years and older through Adverse Events Following Immunization Surveillance System of China.
- Trial name
- NCT02133456
- Volunteers
- 166,240 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Influenza Vaccines
Active Surveillance for Adverse Events Following Immunization With the Influenza Vaccine Produced at Butantan Institute
Rationale and background: Since 2013, IB has been performing passive pharmacovigilance activities related to TIV. Objetive: To implement an active surveillance study as part of our pharmacovigilance plan while passive…
- Trial name
- FLU-05-IB (NCT03057483)
- Testing
- Seasonal Influenza vaccine
- Where
- 2 sites in Brazil
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Extubation, Respiratory Depression
Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory Events
The goal of this study is to investigate the effect of combined acupoint electrical stimulation at Taiyuan (LU9) and Hegu (LI4) on improving the incidence of respiratory adverse events after extubation in patients during the…
- Conditions
- Extubation, Respiratory Depression, Acupuncture Points, Hypoxia
- Trial name
- NCT06772961
- Testing
- Transcutaneous electrical acupoint stimulation, Conventional care plan
- Where
- 2 sites in China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Pediatric Emergency Medicine, Resuscitation
A Clinical Trial to Study the Feasibility and Acceptability of an App to Support Pediatric Resuscitation
The goal of this clinicial trial is to test the acceptability and feasibility of linear cognitive aid intervention to support EMS teams in responding to pediatric emergencies.
- Conditions
- Pediatric Emergency Medicine, Resuscitation, Pediatrics, Emergency Medical Services
- Trial name
- NCT06768099
- Testing
- Linear Cognitive Aid
- Where
- 2 sites in United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Perioperative Respiratory Adverse Events, Airway Management
Airway Management and Weight in Children
The investigators in this study want to see how overweight/obese children who undergo elective surgery requiring airway management react to general anesthesia.
- Trial name
- NCT03996343
- Testing
- Endotracheal intubation, Laryngeal mask airway
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Fever, Adverse Event Following Immunisation
Safety of RSV Preventive Monoclonal Antibody
This is a prospective, randomized, open-label clinical trial to evaluate the safety of administration of respiratory syncytial virus (RSV) preventive monoclonal antibody and other routine childhood vaccines given simultaneously…
- Trial name
- NCT07158814
- Testing
- Respiratory Syncytial Virus (RSV) Preventive Monoclonal Antibody
- Where
- 6 sites in United States
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19
Mix and Match of the COVID-19 Vaccine for Safety and Immunogenicity
The main goals of this study are to assess the immune response and safety of two different vaccines for first, second, third and fourth doses as well as for differing intervals between the first and second dose of two-dose…
- Trial name
- MOSAIC (NCT04894435)
- Testing
- mRNA-1273 SARS-CoV-2 vaccine, BNT162b2, ChAdOx1-S [recombinant]
- Where
- 8 sites in Canada
- Volunteers
- 669 people, healthy volunteers welcome
- Sponsor
- Canadian Immunization Research Network
Growth, Tolerance
Human Milk Oligosaccharides (HMOs) Post-market Study on Infants
Human milk oligosaccharides (HMOs) represent the third largest solid component of breast milk. Technology advancements made it possible to supplement infant formulas with HMOs (2'FL, LNnT).
- Conditions
- Growth, Tolerance, Adverse Event, Disorder of Intestine
- Trial name
- NEHMO (NCT04055363)
- Testing
- HMO-supplemented infant formula
- Where
- 6 sites in Spain
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Influenza, Influenza -Like Illness
Recombinant Influenza Vaccination in U.S. Nursing Homes
Based on recent evidence on the mutation of the A/H3N2 strain in egg-grown vaccine, the investigators will study the quadrivalent recombinant influenza vaccine (RIV4, Flublok) compared to the standard dose quadrivalent vaccine…
- Conditions
- Influenza, Influenza -Like Illness, Influenza, Human
- Trial name
- NCT03965195
- Testing
- Recombinant Influenza Vaccine, Standard Dose Quadrivalent Influenza Vaccine
- Where
- United States
- Volunteers
- 1,989 people, healthy volunteers welcome
- Sponsor
- Insight Therapeutics, LLC