Clinical trials: Adverse Symptoms
Anxiety Disorders, Depression
Interned-delivered Intervention Based on Acceptance Principles
The main objectives for the online intervention were the following: Designing and implementing an internet-delivered prevention program based on acceptance principles, to support LGBT participants to tackle emotional difficulties…
- Conditions
- Anxiety Disorders, Depression, Mental Health Issue, Well-Being
- Trial name
- LGBT (NCT05514964)
- Testing
- Feasibility study
- Where
- Romania
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- West University of Timisoara
Adiposity
Maternal Lipids and Offspring Adiposity at 5-7 Years
This study investigates the associations between measured maternal lipids (Total cholesterol, LDL-cholesterol , triglycerides and high-density lipoprotein cholesterol) at 28 weeks' gestation and offspring adiposity at 5-7 years.
- Trial name
- HAPO (NCT03317522)
- Volunteers
- 1,224 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Pneumonia, Pediatric Disorder
Standardization of Mid-Level Providers Using Point of Care Ultrasound to Diagnose Pediatric Pneumonia
The POCUS training program aims to bring sustainable, affordable access to POCUS to patients in need of diagnostic services in Uganda.
- Conditions
- Pneumonia, Pediatric Disorder, Diagnostic and Monitoring Radiological Devices Associated With Adverse Incidents
- Trial name
- POCUS (NCT03969342)
- Testing
- Point of care ultrasound training
- Where
- Uganda
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bridge to Health Medical and Dental
Cancer, Immune System Disorder
Montreal Immune-Related Adverse Events (MIRAE) Study
Immune checkpoint inhibitors (ICI) are among the most promising approaches to fighting cancer. However, a substantial percentage of patients experience off-target adverse effects in the form of mild to severe inflammation in…
- Conditions
- Cancer, Immune System Disorder, Inflammatory Reaction, Autoimmune Diseases
- Trial name
- MIRAE (NCT05139706)
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Tranexamic Acid Adverse Reaction
Tranexamic Acid in Sleeve Gastrectomy
The effectiveness of Tranexamic acid use will be measured in cases of sleeve gastrectomy in bariatric surgery and in early postoperative bleeding.
- Trial name
- NCT05696951
- Testing
- Transamine 200mg iv
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Musculoskeletal Pain, Musculoskeletal Symptoms
Active Surveillance Reporting to Identify Adverse Events Following Chiropractic Care in Older Adults
In Canada, almost 19% of chiropractic patients are aged over 65 years. Although most of patients ≥65 years seek care for musculoskeletal conditions (such as back, neck and lower limb pain), there is inadequate prospective data on…
- Trial name
- NCT04786015
- Testing
- Active Surveillance Reporting System
- Where
- Canada
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Adverse Events in COVID-19 Vaccination
App-based Symptom Tracking After Corona Vaccination (CoCoV)
The study investigates the side effects of different COVID-19 vaccines.
- Trial name
- NCT04686409
- Testing
- COVID-19 vaccines
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- Aim1 (NCT04767347)
- Testing
- 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Indiana University
Fetal Growth Restriction (FGR), Preterm Birth
Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in…
- Conditions
- Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae
- Trial name
- EPAPOA (NCT07844876)
- Where
- 2 sites in Uganda
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Depression
Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
The purpose of this study is to determine whether pharmacogenomic study of bioamine transporters and peripheral lymphatic biomarkers(phenotype) predict antidepressant responsiveness in advance before the appearance of the drug…
- Trial name
- NCT01352559
- Testing
- responders, non-responders
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Pain, Postoperative
Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy
The objective of this study is compare adverse reactions associated with oxycodone and morphine for the treatment of postoperative pain after abdominal hysterectomy
- Trial name
- NCT02936934
- Testing
- Morphine, Oxycodone
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
COVID-19 Vaccines
The COVID-19 Back-to-Normal Study: Analysis of Multiple Outcomes
During the study, members of different online and offline communities will be followed post COVID-19 vaccination. Injection-site (local) and systemic reaction data will be assessed on vaccination day and afterwards using either…
- Trial name
- NCT04832932
- Testing
- COVID-19 vaccines
- Where
- 5 sites in United States, Georgia and 2 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Mebo Research, Inc.
Neoplasm, Breast, Heart Failure
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both.
- Conditions
- Neoplasm, Breast, Heart Failure, Cardiotoxicity, Ventricular Dysfunction
- Trial name
- BLOC-II (NCT05851053)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome
Gene Sequencing as a Strategy for Identifying Genetic Factors Associated With Serious Adverse Events After Covid-19 Vaccines in Use in Brazil
This protocol proposes to investigate genetic factors that may be involved in the pathogenesis of adverse events of interest with selected covid-19 vaccines: vaccine-induced immune thrombotic thrombocytopenia, and neurological…
- Conditions
- Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome, Acute Disseminated Encephalomyelitis, Transverse Myelitis
- Trial name
- NCT05630313
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Birth Outcome, Adverse, Self Efficacy
The Door to the Womb at Birth: Haptonomy
Purpose: This study aimed to examine the effect of haptonomy application on the expectant mother's birth expectations, experiences, birth self-efficacy, birth memory and reminder during labor.
- Conditions
- Birth Outcome, Adverse, Self Efficacy, Memory Impairment, Pregnancy Related
- Trial name
- NCT06508554
- Testing
- Haptonomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Trakya University
Birth Weight, Birth, Preterm
The Effect of Non-surgical Periodontal Therapy on Adverse Birth Outcomes Randomized Controlled Trial
The main objective of this study is to determine whether the provision of non-surgical periodontal therapy to pregnant women with periodontitis is effective in reducing the incidence of low birth weight, preterm birth and still…
- Trial name
- NSPT (NCT03126006)
- Testing
- NSPT plus oral hygiene, Oral hygiene alone
- Where
- Pakistan
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Aga Khan University