Clinical trials: AdverseEvent
Pain, Postoperative
Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy
The objective of this study is compare adverse reactions associated with oxycodone and morphine for the treatment of postoperative pain after abdominal hysterectomy
- Trial name
- NCT02936934
- Testing
- Morphine, Oxycodone
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
Adverse Drug Events
Reducing Adverse Drug Events in the Nursing Home
Medications are the single most common form of treatment in the long-term care setting, and often represent the most efficacious (and cost-effective) therapeutic modality used in this clinical setting.
- Trial name
- NCT00606606
- Testing
- Clinical Decision Support
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Obesity
Effect of Dietary Components on Gastrointestinal Side Effects Induced by Orlistat, a Lipase Inhibitor
The objective of the Orlifat trial is to investigate if dietary fibres from linseeds and dairy calcium (Capolac ®) may reduce gastrointestinal side effects related to increased fecal fat content, induced by treatment with Alli®…
- Trial name
- ORLIFAT (NCT01320228)
- Testing
- Control, Capolac, Flax fiber
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Drug Hypersensitivity
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase.
- Trial name
- NCT00198458
- Testing
- Vitrase
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Healthy Volunteer
A Study to Assess the Adverse Events and How Bretisilocin Intramuscular Injection Moves Through the Body of Healthy Adult Participants
This study will assess the adverse events, tolerability, and how bretisilocin intramuscular (IM) Injection moves through the body of healthy adult Japanese, Han Chinese, and Non-Asian volunteers participants.
- Trial name
- NCT07604558
- Testing
- Bretisilocin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AbbVie
Diarrhoea
A Study to Evaluate the Effect and Safety of Idoform Plus on Bowel Side Effects in Healthy Subjects Treated With Amoxicillin/ Clavulanate
It is hypothesized that Idoform plus will recuce the occurence of gastrointestinal side effects related to the use of antibiotics
- Trial name
- NCT01491659
- Testing
- Idoform Plus
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Surgical Complication Nec
Effectiveness of a RF Sponge Detection
Retained surgical items (e.g. sponges, needles, and instruments) remain the most frequently reported serious adverse event for five of the last six years.
- Trial name
- NCT02837224
- Testing
- The Situate Detection System
- Volunteers
- 27,637 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Drug-Related Side Effects and Adverse Reactions, Treatment Failure
DOAC ADRs Retrospective Study on Genetic Variations
The purpose of this study is to see if the participant's genetic profile and clinical factors (age, drug dose, etc.) affect drug outcomes (i.e.
- Trial name
- DARES1 (NCT04580589)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cipherome, Inc.
Keratosis, Seborrheic
Electrocautery vs Q-switch for Seborrheic Keratosis
The primary objective of this study is to compare the efficacy and risk of adverse events of electrocautery versus 532 nm Q-switched neodymium-doped yttrium aluminium garnet (Nd:YAG) laser for the treatment of flat seborrheic…
- Trial name
- NCT02366559
- Testing
- Hyfrecator, 532 nm Q-switched Nd:YAG laser
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer
This study uses ambient sensing rooms to collect data from hospitalized cancer patients in order to improve safety and recovery.
- Trial name
- NCT07477886
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiac Toxicity, Acute Leukemia
Association Between Telomere Length and Cardiac Dysfunction
Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to…
- Conditions
- Cardiac Toxicity, Acute Leukemia, Childhood Cancer
- Trial name
- NCT04409379
- Testing
- Relative telomere length
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Sleep Apnea, Obstructive, Sleep Apnea, Central
Variable Dead Space Rebreathing Device to Treat Sleep Apnea
The purpose of this pilot study is to determine the feasibility of using a novel treatment for sleep apnea in which the patient's own exhaled CO2 is tightly controlled and used in a rebreathe system to reduce sleep disordered…
- Trial name
- NCT03552133
- Testing
- Smart CO2
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Adverse Drug Reactions
The Knowledge, Attitudes and Practices of Healthcare Workers on Drug Hypersensitivity Reactions in Children
Adverse drug reactions are an important public health consern that affects physician prescriptions and practice. The responsibilities of healthcare professionals in monitoring, prevention, treatment and reporting of drug…
- Trial name
- KAPHWDHRC (NCT04252326)
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Healthy Volunteer
A Study to Evaluate Adverse Events, How the Drug is Tolerated, and How the Drug Moves Through the Body of Intravenous Infusions of ABBV-8736 in Adult Healthy Volunteers
The objective of this study is to assess the safety, tolerability, pharmacokinetics, and immunogenicity following multiple intravenous (IV) ascending doses of ABBV-8736 in healthy adult participants.
- Trial name
- NCT07141199
- Testing
- ABBV-8736
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy
Pharmacokinetics and Side Effects of the mGlu5 Antagonist Fenobam in Adult Healthy Volunteers
This is a randomized, blinded, parallel group, placebo-controlled trial on 32 evaluable healthy male and non-pregnant female, 18-50 year old volunteers.
- Trial name
- NCT01806415
- Testing
- Fenobam
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Drug Metabolism, Poor, CYP2D6-RELATED
Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Pharmacokinetic of Metoclopramide (MCP) in correlation to polymorphisms of CYP2D6 and Dopamine-D2-Receptor. Pharmacokinetic of Diphenhydramine (DPH) in correlation to polymorphisms of CYP2D6
- Trial name
- MalD (NCT01289938)
- Testing
- Diphenhydramine, Metoclopramide
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Male Circumcision
Safety and Effectiveness of Different ShangRing Device Sizes for Adult Male Circumcision in Lusaka, Zambia
The purpose of this study was to assess the safety, effectiveness and acceptability of providing a reduced number of ShangRing sizes for adult voluntary medical male circumcision (VMMC) within routine service delivery in Lusaka…
- Trial name
- NCT02242565
- Testing
- ShangRing
- Where
- 2 sites in Zambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- FHI 360
Ovarian Cancer
Chemotherapy-Related Toxicities In Ovarian Cancer Patients
Primary Objectives: 1. To assess the preferences of women with ovarian cancer, their clinical caregivers, familial caregivers, and a control group for toxicities associated with chemotherapy.
- Trial name
- NCT00508378
- Testing
- Interview, Questionnaire
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pemphigus, Bullous Pemphigoid
Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
Pemphigus is a rare autoimmune life-threatening blistering condition affecting skin and mucous membranes. Pemphigus belongs to a family of polygenic disorders.
- Conditions
- Pemphigus, Bullous Pemphigoid, Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
- Trial name
- NCT05284929
- Testing
- A single blood sample for HLA typing
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sechenov University
Healthy Volunteers
A Study to Evaluate Adverse Events and How Single Ascending Doses of ABBV-141 Move Through the Body of Healthy Adult Western and Asian Participants
The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK) and immunogenicity after single ascending doses (SAD) of ABBV-141 in healthy adult Western and Asian participants.
- Trial name
- NCT06148181
- Testing
- ABBV-141
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- AbbVie