Clinical trials: AdverseEvent
Myopia
Side Effects of Atropine (SEA) Study
This study will perform several objective and subjective measurements of the eye and vision before and after a week of using 0.01% concentration atropine drops.
- Trial name
- SEA (NCT03593044)
- Testing
- 0.01% concentration atropine drops
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Jeffrey J. Walline, OD PhD
Deep Vein Thrombosis, Pulmonary Embolism
Impact of Pharmacists' Training on Oral Anticoagulant Counseling
This study evaluates the impact of community pharmacists' educational training on the nature and adequacy of counseling provided to patients on warfarin, an oral anticoagulant.
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Atrial Fibrillation
- Trial name
- NCT03999905
- Testing
- Counseling training
- Where
- Nigeria
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ibadan
Breast Cancer, HER2-positive Breast Cancer
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy
The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes.
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Cardiotoxicity
- Trial name
- NCT05019365
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Pneumococcal Infections
Pneumococcal Conjugate Vaccine With Pneumococcal Polysaccharide Vaccine and Tetanus/Diphtheria Vaccine
The purpose of this study is to learn whether or not giving a tetanus/diphtheria vaccination ("tetanus shot") before giving pneumococcal vaccine makes the pneumococcal vaccine more effective without causing too many side effects.
- Trial name
- NCT00164411
- Testing
- Tetanus-diphtheria toxoids (Td), 7-valent pneumococcal conjugate vaccine, 23-valent polysaccharide vaccine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
COVID-19 Vaccine Adverse Reaction
Safety Study About the mRNA Vaccines Against COVID-19 in Children (PEDIVACOV-HCSC)
Drugs side effects in children need to be evaluated in a different way because of their constant growth and body changes. The use of COVID-19 vaccines (mRNA vaccines) is worldwide spread as a safety measure against the pandemic.
- Trial name
- PEDIVACOV-HCSC (NCT06646744)
- Testing
- mRNA COVID-19 vaccine
- Where
- Spain
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Ana Belen Rivas Paterna
Allergic Reaction, Hypersensitivity
Standardised Drug Provocation Testing in Perioperative Hypersensitivity
The goal of this clinical trial is to evaluate the safety and outcome of systematic drug provocation testing with anaesthetics at therapeutic doses in adult patients undergoing diagnostic work-up for perioperative…
- Conditions
- Allergic Reaction, Hypersensitivity, Perioperative Complication, Anaphylaxis
- Trial name
- NCT06065137
- Testing
- Full dose DPT with propofol, Full dose DPT with ketamine, Full dose DPT with etomidate
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Tuberculosis, Drug-Induced Liver Injury
A Pharamcogenomic Study for Isoniazid According to NAT2 Polymorphism Status
A clinical trial to investigate the appropriate dose of isoniazid according to NAT2 polymorphism status in Korean subjects
- Conditions
- Tuberculosis, Drug-Induced Liver Injury, Adverse Drug Event
- Trial name
- NCT03665402
- Testing
- Isoniazid
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Heat Illness, Allergic Rhinitis
Over-the-Counter Antihistamines & Heat Stress
Allergic rhinitis (AR) currently affects ~25% of Canadians, and due to factors of climate change, this number is expected to increase over the coming decade.
- Conditions
- Heat Illness, Allergic Rhinitis, Heat Injury, Sudomotor Sympathetic Dysfunction
- Trial name
- NCT06217367
- Testing
- 50 mg Diphenhydramine, 10 mg Loratadine, 5 mg Desloratadine
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Capecitabine, Hand-foot Syndrome
Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome
This study hypothesizes that electroacupuncture combined with self-administered acupressure plus doctor-prescribed treatment is effective in preventing Hand-Foot Syndrome (HFS) caused by capecitabine.
- Conditions
- Capecitabine, Hand-foot Syndrome, Electroacupuncture, Self-administered Acupressure
- Trial name
- NCT06602167
- Testing
- True electroacupuncture + True self-administered acupressure, Doctor-prescribed treatment
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Qinghai University
Vaccine Adverse Reaction
Genomics and COVID-19 Vaccine Adverse Events
Vaccines routinely used are extremely safe; however, severe adverse events to vaccines do occur. As vaccination against COVID-19 has begun, adverse events to the vaccine, particularly Guillain-Barré syndrome (GBS)…
- Trial name
- NCT05212792
- Testing
- COVID-19 vaccines
- Where
- Canada
- Volunteers
- 6,325 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anxiety Disorders, Depression
Interned-delivered Intervention Based on Acceptance Principles
The main objectives for the online intervention were the following: Designing and implementing an internet-delivered prevention program based on acceptance principles, to support LGBT participants to tackle emotional difficulties…
- Conditions
- Anxiety Disorders, Depression, Mental Health Issue, Well-Being
- Trial name
- LGBT (NCT05514964)
- Testing
- Feasibility study
- Where
- Romania
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- West University of Timisoara
Adverse Events in COVID-19 Vaccination
App-based Symptom Tracking After Corona Vaccination (CoCoV)
The study investigates the side effects of different COVID-19 vaccines.
- Trial name
- NCT04686409
- Testing
- COVID-19 vaccines
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Gastroparesis
A Study to Evaluate Safety, Side Effects, Muscle Activity and Speed of Gastric Emptying of GSK962040
Motilin is a peptide whose action is controlled by motilin receptors located in the gut. Action of Motilin at motilin receptors increases the gastric emptying rate (rate of emptying of food and fluid from the stomach).
- Trial name
- NCT00562848
- Testing
- GSK962040
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Evaluation of Success Rate, Airway Leak Pressure
Evaluation of Supraglottic Airway Devices in Children and Comparison to Historic Control
The supraglottic airway device LMA Supreme has recently been introduced for pediatric patients. The investigators will prospectively evaluate success rate and airway leak pressure in everyday's clinical pediatric anesthesia…
- Conditions
- Evaluation of Success Rate, Airway Leak Pressure, Side Effects of LMA Supreme in Pediatric Patients Undergoing General Anesthesia
- Trial name
- NCT01625858
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Vaccine Adverse Reaction, Gender
Anti-COVID-19 Vaccine Side Effects
In 2021 and following the COVID-19 (corona virus disease 2019) pandemic, different vaccines were initially authorized in Italy and Lebanon. Notably, vaccine side effects were poorly recorded.
- Conditions
- Vaccine Adverse Reaction, Gender, COVID-19 Vaccine Adverse Reaction
- Trial name
- VAX-IT-LEB (NCT05735769)
- Where
- Italy
- Volunteers
- 2,797 people, healthy volunteers welcome
- Sponsor
- University of Bari
Rabies Vaccine Allergy, Vaccination Adverse Event
The Post-Marketing Safety and Immunogenicity Research of Speeda® Rabies Vaccine for Human Use
The objective of this study was to achieve the post-marketing safety and immunogenicity research of Speeda® rabies vaccine for human use from Chengda Bio
- Conditions
- Rabies Vaccine Allergy, Vaccination Adverse Event, Anti-D Antibodies
- Trial name
- NCT01821911
- Testing
- Zagreb2-1-1, Essen
- Where
- 3 sites in China
- Volunteers
- 10,500 people, healthy volunteers welcome
- Sponsor
- Beijing Center for Disease Control and Prevention
Metabolic Side Effects of Drugs and Substances
Metabolic Imprints of Alcoholic Beverages
Metabolic imprints of five different types of alcohol will be investigated in two study groups. The study will be an assessor-blinded, parallel dietary trial (crossover design).
- Trial name
- MetAl (NCT03384147)
- Testing
- Drinking, Abstaining
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Healthy Volunteers
Civamide Patch Safety, Tolerability and PK Study
To evaluate the tolerability of two different strengths of a Civamide Patch (0.0075% and 0.0150%) compared to the placebo patch and each other in healthy adult volunteers.
- Trial name
- NCT00758433
- Testing
- Zucapsaicin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Winston Laboratories
Bipolar Depression
Medication, Weight Gain and GI Hormones
This is an 8 week study that compares two medications. One medication is olanzapine (5-20 mg daily) whereas the other medication is an orally disintegrating medication.
- Trial name
- NCT00384332
- Testing
- orally-disintegrating olanzapine, regular olanzapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University