Clinical trials: AdverseEvent
Breast Neoplasms
Post-Treatment Surveillance in Breast Cancer: Bringing CER to the Alliance
Nearly three million living women have survived breast cancer. Physicians rely on clinical practice guidelines to make decisions on follow-up care.
- Trial name
- NCT02171078
- Where
- United States
- Volunteers
- 34,359 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cognitive Side Effects of Cancer Therapy, Hypoestrogenism
ENDO-BRAIN: Effects of Endocrine Adjuvant Therapy with Aromatase Inhibitors on the Cognitive Function of Breast Cancer Patients
The principal aim of this prospective observational study is to investigate the cognitive function of breast cancer patients that use AI, comparing it with age-matched healthy controls, utilizing cognitive assessments and…
- Trial name
- ENDO-BRAIN (NCT06606535)
- Testing
- validated questionnaires, functional MRI, Optical Coherent Tomography Angiography
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Positron-Emission Tomography
Early Diagnosis of Therapy-associated Cardiotoxicity Basing on PET/CT in Lymphoma
To explore the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging in early diagnosis of treatment-related cardiotoxicity (TACT) of lymphoma using visual method and semi-quantitative method.
- Trial name
- NCT05411250
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Pain, Injection Site Reaction
Safety of Pediatric COVID-19 Vaccination
This is a prospective, observational study. During the study, children and adolescents (ages ≥ 5 to < 16) will be followed post administration of mRNA COVID-19 vaccines.
- Conditions
- Pain, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05157191
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Duke University
Influenza, Vaccines Adverse Reaction
Surveillance for Adverse Events Following Influenza Immunization
Influenza vaccines are continuously modified to adjust to the virus antigenic shifts or drifts, and its safety profile may vary.
- Trial name
- NCT01318876
- Where
- 7 sites in Canada
- Volunteers
- 7,645 people, healthy volunteers welcome
- Sponsor
- PHAC/CIHR Influenza Research Network
Contraception
Safety,Effectiveness and Acceptability of Sino-implant II in DR
A study to assess the contraceptive effectiveness of Sino-implant (II).
- Trial name
- NCT01594632
- Testing
- Jadelle, Sino-implant (II)
- Where
- Dominican Republic
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- FHI 360
Healthy Volunteer
A Study to Assess the Adverse Events and How Bretisilocin Intramuscular Injection Moves Through the Body of Healthy Adult Participants
This study will assess the adverse events, tolerability, and how bretisilocin intramuscular (IM) Injection moves through the body of healthy adult Japanese, Han Chinese, and Non-Asian volunteers participants.
- Trial name
- NCT07604558
- Testing
- Bretisilocin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AbbVie
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Pill.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Pill (XLGB Pill) through a non-intervention observational way.
- Trial name
- NCT03091556
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Root Resorption, Pain
Side Effects of Different Treatment Methods
this study aimed to compare the effects of fixed orthodontic treatment and clear aligner therapy on root resorption, periodontal status, pain experience and chewing performance.
- Conditions
- Root Resorption, Pain, Chewing Function
- Trial name
- NCT06709287
- Testing
- clear aligners, orthodontic metal bracket
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Contraception
A Prospective Observational Study of the Clinical Performance of Femplant in Pakistan
This will be a non-comparative prospective observational study of women using Femplant as a primary method of contraception in Pakistan.
- Trial name
- NCT01463254
- Where
- Pakistan
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- FHI 360
Growth, Tolerance
Human Milk Oligosaccharides (HMOs) - Post Marketing Study on Infants (NeHMO)
Human milk oligosaccharides (HMOs) represent the third largest solid component of breast milk. Technology advancements made it possible to supplement infant formulas with HMOs (2'FL, LNnT).
- Conditions
- Growth, Tolerance, Adverse Event
- Trial name
- NCT07302477
- Testing
- HMO Supplemented Infant Formula
- Where
- 4 sites in Pakistan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Breast Cancer, Circadian Rhythms
The Effects of Light Therapy to Treat Cancer-related Side Effects
Severe fatigue, depression, sleep problems and cognitive impairment are the most commonly reported side effects of cancer treatment.
- Conditions
- Breast Cancer, Circadian Rhythms, Fatigue, Sleep Disturbance
- Trial name
- NCT04418856
- Testing
- Light Glasses (Experimental), Light Glasses (Comparison)
- Where
- Iceland
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Reykjavik University
Cardiac Disease, Covid19
Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT
The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular…
- Conditions
- Cardiac Disease, Covid19, Cardiotoxicity, Extracellular Space Alteration
- Trial name
- NCT04880317
- Testing
- Cardiac Magnetic Resonance, Additional CT acquisition, Blood tests
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Influenza Vaccine, Influenza
Factors Associated With Parental Observation of Side Effects Following the Child Flu Vaccine
This study investigates whether there are psychological predictors of parental perception of side-effects following vaccination with the child flu vaccine.
- Trial name
- NCT02909855
- Testing
- No intervention
- Where
- 11 sites in United Kingdom
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- King's College London
Surgical Complication Nec
Effectiveness of a RF Sponge Detection
Retained surgical items (e.g. sponges, needles, and instruments) remain the most frequently reported serious adverse event for five of the last six years.
- Trial name
- NCT02837224
- Testing
- The Situate Detection System
- Volunteers
- 27,637 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Diarrhoea
A Study to Evaluate the Effect and Safety of Idoform Plus on Bowel Side Effects in Healthy Subjects Treated With Amoxicillin/ Clavulanate
It is hypothesized that Idoform plus will recuce the occurence of gastrointestinal side effects related to the use of antibiotics
- Trial name
- NCT01491659
- Testing
- Idoform Plus
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Randomized, Double-Blind Phase 1 Safety and Tolerability Study of Pafuramidine Maleate (DB289) in Healthy Subjects
This is a phase 1 study to establish the safety and tolerability profile of pafuramidine maleate 100 mg BID administered orally for 14 days to healthy subjects
- Trial name
- NCT00619346
- Testing
- pafuramidine maleate
- Where
- South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Immtech Pharmaceuticals, Inc
Pacemaker Electrode Lead Fracture, ICD
Adverse Events of MRI With Abandoned Leads
The purpose of this study is to determine the safety and efficacy of MRI scanning in patients with fractured or abandoned endocardial leads.
- Trial name
- NCT04478773
- Testing
- MRI
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Neoplasms, Rectal
A Post-marketing Surveillance Study to Assess the Safety of Cervarix (GlaxoSmithKline [GSK] Biologicals' Human Papillomavirus [HPV] -16/18 Vaccine), When Administered According to the Approved Prescribing Information (PI) in Korea
The purpose of this post-marketing surveillance (PMS) study is to collect safety information on the use of Cervarix upon the expanded indication to anal cancer to both women and men (at least 600 Korean women and men) within 30…
- Trial name
- NCT03671369
- Testing
- Safety data collection (following routine vaccination) by a continuous surveillance method.
- Where
- 29 sites in South Korea
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Adverse Drug Events
Eliminating Risk of Preventable Adverse Drug Events at the Hospital-community Interface of Care
This initiative aims to decrease the risk of medication errors at the hospital-community interface as well as health system utilization following hospital discharge by implementing a pharmacist-led medication reconciliation in…
- Trial name
- CMR (NCT01164137)
- Testing
- Medication Reconciliation
- Where
- Canada
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Westview Physician Collaborative