Clinical trials: Aerosol Disease
Bronchial Asthma
Safety, Tolerability, and Pharmacokinetics of PA9159 Inhalation Aerosol in Healthy Adult Subjects
PA9159 is a highly potent novel corticosteroid. The purpose of this study is to exam the safety, tolerability, and pharmacokinetics of single and repeat dosing of Inhalation aerosol PA9159, to establish maximum tolerated dose in…
- Trial name
- NCT06916273
- Testing
- PA9159 Inhalation aerosol, 60 μg one day treatment, PA9159 Inhalation aerosol, 120 μg one day treatment, PA9159 Inhalation aerosol, 240 μg one day treatment
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anhui Palo Alto Pharmaceuticals, Inc.
COVID-19, SARS-CoV2 Infection
Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol
This is a phase 1 study in healthy volunteers who have received at least three doses of an mRNA COVID-19 vaccine, to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT05094609
- Testing
- Ad5-triCoV/Mac, ChAd-triCoV/Mac
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Intubation
Clinical Evaluation of an Aerosol Protective Intubation Device on Videolaryngoscopic Intubation Difficulty
The VACCIN box, an anti-aerosol intubation box for potential use on COVID-19 (SARS-CoV-2) positive patients, was designed in order to reduce the transmission risk to healthcare workers.
- Trial name
- NCT04865081
- Testing
- VACCIN box
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Allergic Rhinitis
Clinical Study to Evaluate the Pharmacokinetics and Safety of BDP HFA Nasal Aerosol
The purpose of this study is to compare the systemic levels of beclomethasone 17 monopropionate (17 BMP - the active metabolite of BDP) after intranasal administration of BDP HFA with the systemic levels of 17 BMP after…
- Trial name
- NCT01537692
- Testing
- BDP HFA Nasal Aerosol, BDP HFA Inhalation Aerosol (QVAR)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Covid19
Evaluation of Aerosol in a Dental Clinic
The purpose of this study is to evaluate the effectiveness of external evacuation units and mouth rinses during aerosol generating procedures in a dental clinic and to determine the risk level to the dental practitioners during…
- Trial name
- NCT04659928
- Testing
- High volume evacuation (HVE), Extraoral vacuum aspirator (EVA), Hydrogen Peroxide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Asthma, Allergic Rhinitis
Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis
This study will provide the clinicians guidance on the safest combination of inhaled and nasal corticosteroids for children with mild asthma and allergic rhinitis respectively; however, one safety concern is that these products…
- Trial name
- NCT01550471
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- West Penn Allegheny Health System
Coronavirus, Covid19
Impact of Aerosol Box Use on Healthcare Provider Contamination
Aerosol Generating Medical Procedures (AGMP) are procedures that have the potential to create tiny particles suspended in the air. These particles can contain germs such as viruses.
- Conditions
- Coronavirus, Covid19, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT04880668
- Testing
- Aerosol Box (Splashguard)
- Where
- 4 sites in United States, Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
Parkinson Disease
Staccato Apomorphine Single and Multi Dose PK
This study will be conducted in 3 parts. A) compare the pharmacokinetics (PK) of a single dose of AZ-009 with that of a therapeutically-relevant dose of a commercially available apomorphine injector in healthy volunteers; B)…
- Trial name
- NCT03822364
- Testing
- 009-1, active comparator, 009-0
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Healthy
The Safety of Tuberculosis Treatments by Oral Inhalation
The inhaled route of delivery has always been associated with the considerable challenge of getting the drug to its target. The lungs are a highly complex organ designed to filter inspired air, with many different cell types…
- Trial name
- NCT01785927
- Testing
- ABCD
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Lung Diseases
Evaluation of Regional Lung Deposition of Inhaled Saline Using the tPAD Device
Purpose: Characterize the depositional attributes of a specialized trans-nasal aerosol delivery device in healthy people using clinical measurements of mucociliary clearance.
- Trial name
- NCT03185650
- Testing
- tPAD Device, PARI LC Star Nebulizer
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease
Characterization of Aerosol Generation and Transport in the Human Lung of Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This study is aiming at evaluating the characteristics of particle emission in subjects with different stages of chronic obstructive pulmonary disease (COPD) compared with healthy smokers.
- Trial name
- NCT01088633
- Testing
- Exhaled particle analysis
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Periodontal Diseases, Dysbiosis
Effect of Aerosol From THS and Cigarette Smoke on Periodontal Tissues and Its Microbiome
Cigarette smoke has an adverse effect on the entire body as well as on the supporting apparatus of the teeth. THS (tobacco heating system) are new products on the market in which tobacco is heated and not burned like in classic…
- Trial name
- NCT06480877
- Testing
- Taking a swab from periodontal pockets or gingival sulci
- Where
- Croatia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Dental Plaque, Calculus, Dental
Dental Isolation Methods in Pediatric Patients
The purpose of this study is to collect, measure, and assess the environmental spatter produced during dental appointments under different isolation methods used in pediatric dentistry, to compare the effectiveness of aerosol…
- Conditions
- Dental Plaque, Calculus, Dental, Aerosol Disease
- Trial name
- NCT04430387
- Testing
- The saliva ejector, The high-volume evacuator, The DryShield
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Tuberculosis
Phase 1 Clinical Trial of the Safety and Immunogenicity of an Adenovirus-based TB Vaccine Administered by Aerosol
This is a phase 1 study, in healthy volunteers who have previously been immunized with bacilli Calmette Guerin (BCG), to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT02337270
- Testing
- Ad5Ag85A
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mucociliary Clearance
Mucociliary Clearance in Healthy Subjects: Comparison of Levalbuterol and Racemic Albuterol
The purpose of this study is to determine whether lung mucociliary clearance (MCC) can be significantly enhanced in healthy subjects by one week of inhalation of nebulized levalbuterol aerosol, as compared to racemic albuterol or…
- Trial name
- NCT00325767
- Testing
- nebulized albuterol (2.5 mg/3ml/dose), nebulized levalbuterol (1.25 mg/3ml/dose)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Aerosol Disease, Caries,Dental
Quantitative Evaluation of Aerosols Produced in the Dental Office
Background: Maintaining biosafety in dental practice requires an efficient elimination of aerosols produced during dental treatment.
- Trial name
- NCT05988359
- Testing
- Caries treatment with a dental turbine, Caries treatment with Er:YAG laser
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Pneumonia
Phase I Single-blind Clinical Trial to Evaluate the Safety and Local Immune Activation of a Toll-like Receptor 5 Agonist (FLAMOD) Administered by Aerosol
This is a single-blind, randomized, placebo-controlled, dose-escalation phase I monocentric trial assessing a single administration of FLAMOD by aerosol in healthy subjects.
- Trial name
- NEBUFLAG (NCT06681402)
- Testing
- FLAMOD
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Covid19, Fear
Correlation Fear of COVID-19 & Dental Treatment Anxiety
Purpose: COVID-19 Pandemic has created fears, anxiety and worries among general population. COVID-19 airborne transmission is possible under circumstances in which procedures generate aerosols.
- Conditions
- Covid19, Fear, Dental Anxiety
- Trial name
- NCT04497818
- Testing
- Cross Sectional study using scientifically validated psychometric Scales
- Where
- Saudi Arabia
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Qassim University
Healthy, Dyspnea
Aerosol Inhalation Treatment for Dyspnea
The purpose of this protocol is to develop and test optimal delivery of aerosol furosemide, a treatment that has the potential to significantly improve symptom management and enhance the quality of care for patients with…
- Trial name
- NCT01440764
- Testing
- Furosemide, Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Obstructive Pulmonary Disease Moderate, Obesity
Aerosol Therapy in Obese COPD Patients.
This study has the objective to clarify the factors that directly influence the effectiveness of inhaled drug deposition in obese patients with chronic obstructive pulmonary disease (COPD) and suggest the use of High Flow Nasal…
- Trial name
- NCT03031093
- Testing
- inhalation protocol, High Flow Nasal Cannula
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte