Clinical trials: Aerosol Therapy
Chronic Pulmonary Aspergillosis
Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole
This study compares the therapeutic (clinical and radiological) efficacy of a six-month treatment by itraconazole and nebulised Ambisome® (liposomal amphotericin B = LAmB) versus treatment by itraconazole alone, in non - or…
- Trial name
- NCT03656081
- Testing
- inhaled Ambisome®, Itraconazole
- Where
- France
- Volunteers
- 224 people
- Sponsor
- Poitiers University Hospital
Asthma
A BE Study to Compare Beclomethasone Dipropionate Inhalation Aerosol, 40 mcg and QVAR® 40 mcg, Inhalation Aerosol
To compare the efficacy and safety profiles of Beclomethasone dipropionate Inhalation Aerosol, 40 mcg (test product) and QVAR 40 mcg (beclomethasone dipropionate HFA), Inhalation Aerosol (reference product) and to demonstrate…
- Trial name
- NCT03562949
- Testing
- Test Product, Reference Product
- Where
- 12 sites in United States
- Volunteers
- 761 people
- Sponsor
- Amneal Ireland Limited
Asthma, COPD
Breathing Parameter Measurements for Lung Deposition Simulation
This study aims to simulate the deposition of aerosol drugs within the airways of asthma and COPD patients based on realistic breathing patterns measured at different pulmonology centers.
- Trial name
- CHOICE (NCT05445349)
- Testing
- Emptied dry powder inhalers (DPI) used in routine asthma and COPD therapy
- Where
- 3 sites in Hungary
- Volunteers
- 163 people
- Sponsor
- Medisol Development Kft.
Pulmonary Disease, Chronic Obstructive
12 Week Comparison of 5 Mcg and 10 Mcg of Tiotropium / Respimat, Placebo and Ipratropium MDI in COPD
The primary objective was to compare the bronchodilator efficacy of two doses (5 mcg and 10 mcg) of tiotropium inhalation solution delivered by the Respimat inhaler once daily to placebo and to ipratropium bromide MDI four times…
- Trial name
- NCT00239473
- Testing
- 5 mcg once daily tiotropium inhalation solution delivered by the Respimat inhaler, 10 mcg once daily tiotropium inhalation solution delivered by the Respimat inhaler
- Where
- 38 sites in Germany, Italy and 2 more
- Volunteers
- 429 people
- Sponsor
- Boehringer Ingelheim
Pneumonia, Pneumocystis Carinii, HIV Infections
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe…
- Trial name
- NCT00001013
- Testing
- Trimetrexate glucuronate, Pentamidine isethionate, Sulfamethoxazole-Trimethoprim
- Where
- 23 sites in United States
- Volunteers
- 364 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical Symptoms
To confirm the ability of pulmonary (lung) function testing (PFT) to detect Pneumocystis carinii pneumonia (PCP) before the development of clinical symptoms and to determine if pentamidine (PEN), a drug used in treating PCP, can…
- Trial name
- NCT00000707
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gastric Cancer, Peritoneal Carcinomatosis
PIPAC and FOLFOX for Gastric Cancer Peritoneal Cancer
Peritoneum is among the most common sites of metastases in gastric cancer. Systemic chemotherapy is the current standard for peritoneal carcinomatosis (PC), although, the treatment results remain extremely poor.
- Trial name
- NCT05644249
- Testing
- Combined Doxorubicin and Cisplatin Pressurized IntraPeritoneal Aerosol Chemotherapy With Systemic FOLFOX chemotherapy
- Where
- 2 sites in Lithuania
- Volunteers
- 37 people
- Sponsor
- Vilnius University
Chronic Obstructive Pulmonary Disease
Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging
The goal of this clinical trial is to compare responses to bronchodilator treatment delivered by three different aerosol delivery methods in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT06271408
- Testing
- Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution, Vibrating Mesh Nebulizer, Metered Dose Inhaler
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Polarean, Inc.
Transmission, Patient-Professional
Different Modalities in Reducing Airborne Particulate Concentrations During AGP for Health Volunteers
Several clinical procedures have been described as aerosol generating procedure (AGP), including nebulization, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and bronchial hygiene treatment, etc.
- Trial name
- NCT04681599
- Testing
- Filter, Scavenger face tent
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Peritoneal Metastases from Colorectal Cancer
Systemic Antitumor Treatment with or Without Pressurized Intraperitoneal Aerosol Chemotherapy for Colon Peritoneal Metastases (PIPOX02)
The goal of this clinical trial is to learn if Pressurized intraperitoneal aerosol chemotherapy (PIPAC) significantly improve the progression-free survival (PFS) in patients with advanced peritoneal metastasis from colorectal…
- Trial name
- PIPOX02 (NCT06681038)
- Testing
- Standard Medical Therapy, PIPAC
- Where
- 15 sites in France
- Volunteers
- 114 people
- Sponsor
- Institut Cancerologie de l'Ouest
COPD Exacerbation
COPD Aerosol Study Comparing the Efficacy of Nebulizers Versus Dry Powder Inhalers
The purpose of this study is to compare drug delivery and lung function after treatment with formoterol from a nebulizer versus a dry powder inhaler (DPI) in patients recovering from severe exacerbations of COPD.
- Trial name
- NCT02291016
- Testing
- Formoterol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Respiration, Artificial, Critical Care
Aerosol Therapy in Intensive Care Units
Unlike in the outpatient setting, delivery of aerosols to ICU patients may be considered complex, particularly in ventilated patients.
- Trial name
- ATICU (NCT03597334)
- Testing
- aerosol therapy
- Where
- China
- Volunteers
- 1,095 people
- Sponsor
- lvshan
Allergic Rhinitis (Disorder)
Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis
The purpose of this study was to evaluate the effects of Ischia thermal waters nasal irrigation on allergic rhinitis and airway inflammation during the period of natural exposure to parietaria pollen in children with allergic…
- Trial name
- NCT01326247
- Testing
- thermal waters nasal irrigation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
COVID-19
A Study to Assess the Safety, Tolerability and Preliminary Efficacy of HH-120 for the Treatment of COVID-19
This is a randomized, double-blind, placebo-controlled Phase 1 study in participants over the age of 18 years with mild to moderate COVID-19.
- Trial name
- NCT06039163
- Testing
- HH-120
- Where
- 4 sites in China
- Volunteers
- 37 people
- Sponsor
- Huahui Health
Covid19
Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)
Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2) Severe acute respiratory syndrome coronavirus 2…
- Trial name
- NCT04578236
- Testing
- Aerosolized 13 cis retinoic acid plus Inhalation administration by nebulization captopril 25mg, Drug: Standard treatment Standard treatment
- Volunteers
- 360 people
- Sponsor
- Kafrelsheikh University
Coronavirus
A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia
In December 2019, a novel coronavirus infectious disease characterized by acute respiratory impairment due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan city of Hubei province in China.
- Trial name
- NCT04276987
- Testing
- MSCs-derived exosomes
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Cystic Fibrosis
Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis
The aim of this study is to investigate the efficacy of antibiotic therapy with any antibiotic (IV) and IV (Nebcin®) tobramycin for 5 days followed by Solution for nebuliser inhalation (Tobi®) for 9 days and antibiotic cures…
- Trial name
- TOBRAMUC (NCT03066453)
- Testing
- Tobi Inhalant Product, Nebcin
- Where
- 7 sites in France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Skin and Connective Tissue Diseases
A Psoriasis Plaque Test Trial With LEO 90100 Compared to Betesil® in Patients With Psoriasis Vulgaris
The purpose of this study is to evaluate the anti-psoriatic effect of LEO 90100 aerosol foam compared with Betesil® medicated plaster
- Trial name
- NCT02518048
- Testing
- LEO 90100 Aerosol foam, Betesil® 2.25 mg
- Where
- France
- Volunteers
- 35 people
- Sponsor
- LEO Pharma
Pulmonary Fibrosis
A Pilot Study of Aerosol Interferon-gamma for Treatment of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease for which there is no effective treatment. Interferon-gamma is a medication that has been used for other lung diseases to decrease scarring and fibrosis.
- Trial name
- NCT00563212
- Testing
- aerosol interferon-gamma
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
Respiratory Insufficiency
RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
Aerosol delivery during mechanical ventilation has long been a long debated topic. As evidence-based knowledge about the delivery of aerosol to the lungs of mechanically ventilated patients increases, one piece of the puzzle has…
- Trial name
- NCT02056119
- Testing
- Vibrating Mesh Nebulizer Arm, Jet Nebulizer Arm
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rush University Medical Center