Clinical trials: Aetiology
Retinitis Pigmentosa
Oral Hydroxychloroquine (HCQ) for Retinitis Pigmentosa Caused by P23H- Rhodopsin (RHO)
This research study is being done to learn what effect 12 months of treatment with oral hydroxychloroquine (HCQ) will have on the retina in people with retinitis pigmentosa (RP).
- Trial name
- NCT04120883
- Testing
- Hydroxychloroquine lower dose, Hydroxychloroquine higher dose
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Low Back Pain, Medicine, Korean Traditional
The Effectiveness and Safety of T-MSAT on Inpatients With Acute Low Back Pain Caused by Traffic Accidents : A Randomized Controlled Trial
This study is a single blind, randomized controlled trial. condition/disease: acute low-back pain treatment/intervention: Motion Style Acupuncture Treatment using Traction (T-MSAT)
- Trial name
- NCT04554446
- Testing
- T-MSAT(Motion style acupuncture treatment using traction), Korean medicine treatment
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Jaseng Medical Foundation
COVID, Pneumonia, Viral
Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)
Pneumonia is a recurrent element of COVID-19 infection, it is often associated with development of respiratory failure and patients frequently need various degrees of oxygen therapy up to non invasive ventilation (NIV-CPAP) and…
- Conditions
- COVID, Pneumonia, Viral, Barotrauma, Interstitial Lung Disease
- Trial name
- SequelaeCov (NCT04435327)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milano Bicocca
Retinitis Pigmentosa
Safety and Efficacy of ZVS203e in the Treatment of Retinitis Pigmentosa Caused by RHO Gene Mutation
This trial employs a single-arm, open-label seamless Phase I/II design, consisting of two stages: Phase I dose exploration and Phase II dose expansion.The primary objective of this trial is to evaluate the safety, tolerability…
- Trial name
- ZVS203e (NCT06952842)
- Testing
- ZVS203e
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chigenovo Co., Ltd
Vision Disorders
A Predictive Score for the Ischemic Etiology of a Transient Visual Disturbances (VASCO)
The transient visual disturbances (TVD) are defined by a short abnormality of visual function. Their etiology may be ophthalmological, neurological non-ischemic or of ischemic origin.
- Trial name
- VASCO (NCT02485054)
- Testing
- Clinical, ophthalmological and neurological evaluation
- Where
- 2 sites in France
- Volunteers
- 403 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Myocardial Infarction, DM
Causes of Delayed Presentation of MI Patients to a Tertiary Care Hospital
This study is being done to learn more about people who have had a heart attack, also called a myocardial infarction (MI). A heart attack happens when blood flow to the heart muscle is blocked, causing damage.
- Conditions
- Myocardial Infarction, DM, HTN-Hypertension
- Trial name
- Delay-MI (NCT07160556)
- Testing
- Observational
- Where
- Pakistan
- Volunteers
- 362 people
- Sponsor
- Bacha Khan Medical College
Hyperuricemia
Lowering Serum Uric Acid to Prevent Acute Kidney Injury
Acute kidney injury is associated with a rise in serum uric acid during cardiovascular surgery and can cause poor blood flow to the kidneys making them vulnerable to kidney injury.
- Trial name
- RasbAKI (NCT00756964)
- Testing
- Rasburicase
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
Enteritis Caused by Radiation (Disorder)
Pharmacokinetics, Safety, and Tolerability of SYN-020
This is a Phase 1, single-center, open-label, single ascending dose study to assess the PK, safety, and tolerability of SYN-020 delayed release capsules administered orally to healthy adult male and female subjects with a BMI of…
- Trial name
- NCT04815993
- Testing
- SYN-020 delayed release capsule
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Theriva Biologics, Inc.
Movement of Thoracic and Lumbar Skin
How Much Can the Thoracic and Lumbar Skin Slide?
The investigators want to determine how much the skin on the back can move left to right of the midline and also up and down, in subjects presenting for procedure or in healthy volunteers.
- Trial name
- NCT02105363
- Testing
- measure of skin movement on surface of the back, Measurement of skin movement on surface of back
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Dementia; Alzheimer, Mixed Type (Etiology)
Probiotics in Dementia
Dementia is associated with changes in gut microbiome composition, gut barrier dysfunction, intestinal inflammation and systemic inflammation. Probiotics are a possibility to modulate the gut-brain axis.
- Trial name
- PIDE (NCT03847714)
- Testing
- Omni-Biotic Stress Repair
- Where
- Austria
- Volunteers
- 17 people
- Sponsor
- Medical University of Graz
Anemia, Weightlessness
Causes and Mechanisms of Space Hemolysis At High Altitudes
Anemia is a lack of red blood cells (RBCs) in the circulation. Because RBCs carry the oxygen your body needs to function, anemia can affect one's ability to stay awake, alert, and perform physical activities.
- Trial name
- ANEMIA (NCT05496309)
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Ottawa Hospital Research Institute
Anemia
A Study to Determine the Safety and Effectiveness of Epoetin Alfa Versus Placebo in Patients With Persistent Anemia Caused by Advanced Cancer
The purpose of this study is to determine the safety and effectiveness of epoetin alfa versus placebo, injected beneath the skin, in the treatment of patients with persistent anemia caused by advanced cancer, with a below normal…
- Trial name
- NCT00269984
- Testing
- Epoetin alfa
- Volunteers
- 56 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Testicular Cancer
Cause of Familial Testicular Cancer
Background: People with a family history of testicular cancer may be at increased risk for the disease. Genetic and clinical studies of patients with testicular cancer and their family members may help clarify the cause of the…
- Trial name
- NCT00034424
- Where
- United States
- Volunteers
- 749 people
- Sponsor
- National Cancer Institute (NCI)
COVID-19
Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)
The Austrian Coronavirus Adaptive Clinical Trial (ACOVACT) is a randomized, controlled, multicenter, open-label basket trial that aims to compare various antiviral treatments for COVID-19.
- Trial name
- ACOVACT (NCT04351724)
- Testing
- Chloroquine or Hydroxychloroquine, Lopinavir/Ritonavir, Best standard of care
- Where
- 9 sites in Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bronchitis, Bronchitis, Chronic
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid onset of…
- Trial name
- NCT00257140
- Testing
- levofloxacin
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Muscular Atrophy, Sprains
Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel
The aim of this study is to determine that ibuprofen 50mg/g gel is effective and safety treating patients with muscle aches, joint pains or due to sprains, bruises, tendinitis or myofascial compared to Profenid 25mg/g gel.
- Conditions
- Muscular Atrophy, Sprains, Tendonitis
- Trial name
- NCT01373697
- Testing
- Ibuprofen, Profenid
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- Laboratório Teuto Brasileiro S/A
Heart Failure
First in Man Study of Implantable Alginate Hydrogel
The objective of this clinical research is to evaluate the safety and effectiveness of Implantable Alginate Hydrogel to reconstruct the left ventricle in the treatment of heart failure
- Trial name
- NCT04781660
- Testing
- Implantable Alginate Hydrogel
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Homocystinuria Due to CBS Deficiency
Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)
The purpose of the study is to characterize the clinical course of homocystinuria in pediatric and adult patients aged 1 to 65 years under current clinical management practices
- Trial name
- NCT02998710
- Where
- 11 sites in United States, Ireland and 2 more
- Volunteers
- 110 people
- Sponsor
- Travere Therapeutics, Inc.
Clinically Significant Bacteremia
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to Extended-spectrum Beta-lactamase (ESBL) or Carbapenemase-producing Enterobacteriaceae: an Observational Multinational Study
Main objective: to observationally assess the efficacy of different antimicrobials in Bloodstream Infection (BSI) due to Enterobacteriaceae producing ESBLs or carbapenemases.
- Trial name
- INCREMENT (NCT01764490)
- Where
- Spain
- Volunteers
- 1,344 people
- Sponsor
- JESUS RODRIGUEZ BAÑO
Procedural Pain, Pain, Acute
The Effect of Facilitated-tucking and ShotBlocker on Pain Caused by Vaccination in Healthy Infants
This study will be investigated the effects of facilitated tucking, ShotBlocker and combined facilitated tucking and ShotBlocker methods on procedural pain, crying time and duration of the procedure during Hepatitis B vaccine…
- Conditions
- Procedural Pain, Pain, Acute, Nursing Caries
- Trial name
- NCT06377748
- Testing
- Facilitated tucking position, ShotBlocker, Combined facilitated tucking and ShotBlocker
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
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