Clinical trials: Aetiology
Out-Of-Hospital Cardiac Arrest
The Systematic Approach for Identification of Cause Among Out-of-hospital Cardiac Arrest Survivors
The cause of cardiac arrest mostly determines outcomes of cardiac arrest survivors. Identifying and treating the cause of cardiac arrest constitute a critical part in post-arrest care.
- Trial name
- NCT06012838
- Testing
- Cause classification of OHCA protocol
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Hemoptysis, Haemoptysis
Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis
The study consist of a retrospective analysis of the etiologies, investigations and outcomes of patients presenting between 2005 to 2010 with hemoptysis in a North-American Tertiary center.
- Conditions
- Hemoptysis, Haemoptysis, Lung Disease, Pneumonia
- Trial name
- NCT02913365
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Université de Sherbrooke
Chronic Obstructive Pulmonary Disease
A RESearch on the PrEvalence and the Diagnosis of COPD and Its Tobacco-related Etiology
The aim of the RESPECT study is to gain a better understanding of the prevalence, pathogenesis and symptoms of early chronic obstructive pulmonary disease (COPD).
- Trial name
- RESPECT (NCT02307799)
- Where
- 2 sites in Russia
- Volunteers
- 3,133 people
- Sponsor
- Université Catholique de Louvain
Mastocytosis
Cause and Natural Course of Pediatric-Onset Mastocytosis
This study will evaluate children with mastocytosis, a disease of excessive mast cells in tissues such as skin and bone marrow, to identify the cause of the disease and describe its course.
- Trial name
- NCT00050193
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oral Cancer, Oropharyngeal Cancer
Speech-based AI-driven Diagnostics and Rehabilitation for Oral and Oropharyngeal Cancer.
Participants diagnosed with oral cancer, oropharyngeal cancer, or oral potentially malignant lesions, as well as healthy controls, had their speech audio recordings collected for the development and validation of AI-driven models…
- Trial name
- speech omics (NCT07347899)
- Where
- China
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Yudong Xiao
Child Development
The Effect of Early-life Risk Factors on the Etiology of Diabetes in Children: a Birth Cohort
In recent years, with the rising prevalence of obesity among children, the incidence of type 2 diabetes in children and adolescents has continued to be increased.
- Trial name
- NCT04313998
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sijia Gu
Influenza Nos or Influenza-like Illness, Acute Respiratory Infections
A Study to Determine the Causes and Identify Increases in Influenza-Like Illness (ILI) in Mexico
The purpose of this observational study is to characterize individuals in Mexico who seek medical care for influenza-like illness (ILI) and Severe Acute Respiratory Infection (SARI), describe seasonal pattern of the pathological…
- Trial name
- NCT02378090
- Where
- 6 sites in Mexico
- Volunteers
- 888 people
- Sponsor
- Mexican Emerging Infectious Diseases Clinical Research Network
Hyponatremia, Hyponatremia With Extracellular Fluid Depletion
Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status
Hyponatremia is the most frequent electrolyte disorder encountered in clinical practice. The patient approach, however, is still problematic, above all because hyponatremia is a manifestation correlated to various pathological…
- Conditions
- Hyponatremia, Hyponatremia With Extracellular Fluid Depletion, Hyponatremia With Normal Extracellular Fluid Volume, Hyponatremia With Excess Extracellular Fluid Volume
- Trial name
- NCT04402190
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Irritable Bowel Syndrome, Sucrose Intolerance Due to Sucrase-Isomaltase Deficiency
Sucrase-isomaltase Deficiency as a Cause of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a functional disorder causing troublesome symptoms and reduced quality of life. It affects 10-20% of the population, hence creates large costs for society.
- Conditions
- Irritable Bowel Syndrome, Sucrose Intolerance Due to Sucrase-Isomaltase Deficiency, Carbohydrate; Malabsorption, Sucrase Isomaltase Deficiency
- Trial name
- NCT05159115
- Testing
- Low-FODMAP diet, Starch- and Sucrose Reduced Diet (SSRD)
- Volunteers
- 80 people
- Sponsor
- Lovisenberg Diakonale Hospital
Bronchitis, Bronchitis, Chronic
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid onset of…
- Trial name
- NCT00257140
- Testing
- levofloxacin
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Demographic Profiles, Impairment Certificates
Patients Seeking a Visual Impairment Certificate
This study investigates the prevalence, causes, and demographic characteristics of patients seeking visual impairment certificates at Assiut Ophthalmology Hospital.
- Conditions
- Demographic Profiles, Impairment Certificates, Visual Impairment
- Trial name
- NCT06900855
- Volunteers
- 383 people
- Sponsor
- Assiut University
Perinatal Mortality, Cause of Neonatal Death
Verbal Autopsy to Assess Early Neonatal Death and Stillbirth
The NICHD Global Network (GN) for Women's and Children's Health Research, a multi-site, international research network, provides a unique infrastructure to implement an expanded perinatal verbal autopsy study using the FIRST…
- Conditions
- Perinatal Mortality, Cause of Neonatal Death, Cause of Stilbirth
- Trial name
- VA (NCT00640055)
- Testing
- Coordinator, Physician-assigned cause of death
- Where
- 4 sites in Guatemala, Pakistan and 2 more
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Diabetic Retinopathy
Loss to Follow-up in PDR Patients
This study determined the clinical impact and causes of loss to follow-up (LTFU) from the patients' perspective in individuals with proliferative diabetic retinopathy (PDR) who received panretinal photocoagulation (PRP) and/or…
- Trial name
- NCT04018326
- Volunteers
- 467 people
- Sponsor
- Assiut University
Cervical Radiculopathy
Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?
"Does low-does cervical epidural lidocaine cause transient weakness?"
- Trial name
- NCT03382925
- Testing
- cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Heart Failure, Heart Failure, Systolic
Predicting Heart Failure Outcomes With Biomarkers and Imaging
This study aims to develop a better model to predict one-year risk of death in patients with heart failure. We will test whether combining information from routine blood tests (like NT-proBNP) and heart scans (measuring features…
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- BIOPHF (NCT07332520)
- Volunteers
- 4,000 people
- Sponsor
- Xinjiang Medical University
Pneumonia
A Randomized Controlled Trial (RCT) of Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia Caused by Drug-resistant Gram-negative Bacilli
Through a prospective randomized controlled trial, we systematically evaluate the effects of Yiqi Huoxue Jiedu Formula combined with bacteriophage therapy on the bacterial clearance rate, disease improvement rate and mortality…
- Trial name
- NCT07338123
- Testing
- YHDF Drug, Bacteriophage
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Type2 Diabetes, Myocardial Infarction
Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events
The purpose of this study is to compare the risk of cardiovascular events associated with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in comparison with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors among…
- Conditions
- Type2 Diabetes, Myocardial Infarction, Ischemic Stroke, Cardiovascular Death
- Trial name
- NCT03939624
- Testing
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors, Dipeptidyl peptidase-4 (DPP-4) inhibitors
- Where
- Canada
- Volunteers
- 419,734 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Aspergillosis, Candidiasis
Post Marketing Study to Evaluate the Safety and Efficacy of Micafungin Against Fungal Infections Caused by Candida Spp or Aspergillus Spp
The objective of this study is to evaluate the safety and efficacy of intravenous micafungin for the treatment of adult patients in China infected by Candida spp or Aspergillus spp.
- Trial name
- NCT02646800
- Testing
- Micafungin
- Where
- 16 sites in China
- Volunteers
- 105 people
- Sponsor
- Astellas Pharma China, Inc.
Bradyarrhythmia, Atrioventricular Block
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period.
- Conditions
- Bradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area Pacing
- Trial name
- NCT05585411
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Yonsei University
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