Clinical trials: Aetiology
Cardiomyopathy, Heart Failure
Bone Marrow Derived Mesenchymal Stem Cells in Improving Heart Function in Patients With Heart Failure Caused by Anthracyclines
This randomized pilot phase I trial studies the side effects and best method of delivery of bone marrow derived mesenchymal stem cells (MSCs) in improving heart function in patients with heart failure caused by anthracyclines (a…
- Trial name
- NCT02408432
- Testing
- Laboratory Biomarker Analysis, Standard of Care, Mesenchymal Stem Cell Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Cushing's Syndrome, Healthy
Study of Cushing's Syndrome Not Related to ACTH Production
This study is designed to provide information about the cause of two unusual types of Cushing's syndrome and to evaluate quality of life before and after cure of the disease.
- Trial name
- NCT00006278
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Arthritis, Rheumatoid, Vitamin D Deficiency
Vitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid Arthritis
Recent studies have demonstrated that subjects with low blood levels of vitamin D are at a higher risk of developing autoimmune diseases such as Rheumatoid Arthritis (RA).
- Trial name
- NCT00279461
- Where
- United States
- Sponsor
- Indiana University
Osteoarthritis, Knee
HKT-500-US12 In Adult Patients With OA Knee Pain
The objective of this study is to characterize the analgesic properties of single dose study of HKT-500 in subjects with pain caused by mild to moderate OA of the knee
- Trial name
- NCT00647231
- Testing
- HKT-500 Topical Patch
- Where
- 29 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Neonatal Hypoglycemia, Metabolic Disease
Pattern of Metabolic Causes of Neonatal Hypoglycemia
Inborn errors of metabolism (IEM) are disorders in which there is a block at some point in the normal metabolic pathway caused by a genetic defect of a specific enzyme.
- Trial name
- NCT05977972
- Volunteers
- 100 people
- Sponsor
- Assiut University
Erectile Dysfunction, Spinal Cord Injuries
Efficacy and Safety of Tadalafil in Subjects With Erectile Dysfunction Caused by Spinal Cord Injury
This is a study of the efficacy and safety of on-demand dosing of tadalafil or placebo administered for 12 weeks to men with erectile dysfunction caused by spinal cord injury.
- Trial name
- NCT00421083
- Testing
- tadalafil
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Eli Lilly and Company
Vitamin D Deficiency, Carotid Artery Diseases
Vitamin D Deficiency as Independent Predictor for Plaque Vulnerability
Role of vitamin D in cardiovascular disease is controversial. Here the investigators aimed to investigate the association of vitamin D deficiency and carotid plaque morphology as well as outcome of participants with high-grade…
- Trial name
- NCT06473337
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 332 people
- Sponsor
- Medical University of Vienna
Arthritis; Psoriasis (Etiology)
Assessment of the Clinical and Ultrasound Response to Apremilast by Clinical Evaluation and by a Joint-periarticular-nail Ultrasound Index in Patients With Active Psoriatic Arthritis
This study aims to evaluate more objectively, through an imaging technique such as ultrasound, changes in joints and entheses of patients with active psoriatic arthritis (PAs) who will start treatment with Apremilast after the…
- Trial name
- APREMILAST (NCT03191539)
- Testing
- Apremilast
- Volunteers
- 56 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Crohns Disease
Impaired Insulin-like Growth Factor-1 (IGF-1) Generation Causes Protein Catabolism and Poor Growth in Children With Crohn Disease
The investigators will prospectively recruit 26 children with moderate - severe active Crohn disease (PCDAI >30). Results will be compared to 26 patients in sustained remission (PCDAI <10 and physician global assessment of…
- Trial name
- NCT00946361
- Testing
- Examinations
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Nationwide Children's Hospital
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Insulin Sensitivity/Resistance, Breast Cancer
Insulin Sensitivity After Breast Cancer
Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes.
- Conditions
- Insulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance
- Trial name
- NCT05010356
- Testing
- Insulin
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Prevention of Nausea and Vomiting Caused by Highly Emetogenic Chemotherapy
Study of HR20013 for Injection in Patients With Malignant Solid Tumors
To evaluate the safety and pharmacokinetics of single-dose HR20013 for injection combined with dexamethasone in patients with malignant solid tumors receiving cisplatin-based chemotherapy.
- Trial name
- NCT05465681
- Testing
- HR20013 for injection；dexamethason
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Cough
Study of the Efficacy and Safety of SCH 619734 in Subjects With Chronic Cough From an Unknown Cause (Study P04888)
This is a randomized, double-blind, placebo-controlled, crossover, single center study of SCH 619734 in subjects with chronic cough from an unknown cause.
- Trial name
- NCT00506545
- Testing
- SCH 619734
- Volunteers
- 35 people
- Sponsor
- Merck Sharp & Dohme LLC
Oral Complications, Quality of Life
Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids
RATIONALE: Pilocarpine may help to relieve dry mouth in patients receiving opioids for cancer therapy. It is not yet known whether pilocarpine is more effective than no further treatment for this condition.
- Trial name
- NCT00003686
- Testing
- pilocarpine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- NCIC Clinical Trials Group
Cardiovascular Diseases, Peripheral Vascular Diseases
Etiology and Prevalence of Peripheral Arterial Disease
To determine the prevalence of peripheral arterial disease in a defined population by non-invasive techniques; to evaluate the association of cardiovascular disease risk factors with peripheral vascular disease; to determine…
- Conditions
- Cardiovascular Diseases, Peripheral Vascular Diseases, Arterial Occlusive Diseases
- Trial name
- NCT00005142
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tooth Sensitivity, Toothache
Piroxicam-beta-Cyclodextrin on Tooth Sensitivity Caused by In-office Bleaching
Objectives: This study aims to evaluate the effectiveness of preemptive administration of non-steroidal anti-inflammatory Piroxicam-beta-Cyclodextrin on risk and level of tooth sensitivity caused by in-office bleaching procedures…
- Trial name
- NCT03153657
- Testing
- Piroxicam-Beta-Cyclodextrin
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Chronic Pruritus
Causes of Chronic Pruritus
The aim of this study is to include all patients followed between 2008 and 2018 in order to analyze the etiologie of the chronic pruritus
- Trial name
- PRURISINE (NCT04949893)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Chronic Wound, Myofascial Pain Syndrome
Extended Therapeutic Effect of 35kDa Hyaluronan Fragment Injection in Patients With Chronic Pain Caused by Myofascial Pain Syndrome
To verify the efficacy and safety of HA35 in chronic pain management and to further supplement effective treatments for chronic pain, we designed a proof-of-concept clinical study.
- Trial name
- NCT06444035
- Testing
- HA35 injection
- Where
- Mongolia
- Volunteers
- 10 people
- Sponsor
- Nakhia Impex LLC
Dry Eye Syndrome
Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction
This study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused by meibomian gland dysfunction and make a comparison between the traditional treatment.
- Trial name
- NCT02958514
- Testing
- intense pulsed light, Tobramycin and Dexamethasone Ophthalmic Ointment
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Endometrial Cancer
Molecular Staging of Endometrial Cancer
This study, sponsored by NCI and the Gynecologic Oncology Group (GOG), will collect tissue samples from women with cancer of the endometrium (lining of the uterus).
- Trial name
- NCT00340808
- Where
- United States
- Volunteers
- 5,492 people
- Sponsor
- National Cancer Institute (NCI)
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