Clinical trials: Aetiology
Movement of Thoracic and Lumbar Skin
How Much Can the Thoracic and Lumbar Skin Slide?
The investigators want to determine how much the skin on the back can move left to right of the midline and also up and down, in subjects presenting for procedure or in healthy volunteers.
- Trial name
- NCT02105363
- Testing
- measure of skin movement on surface of the back, Measurement of skin movement on surface of back
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
COVID, COVID-19
Subcutaneous Sarilumab vs Placebo in Hospitalized Patients With Respiratory Distress Caused by COVID 19
Studying the efficacy of IL-6 inhibition utilizing single or double dose subcutaneous administration of Sarilumab in patients with severe respiratory distress caused by COVID19 regarding improvement in oxygen demands and other…
- Conditions
- COVID, COVID-19, Corona Virus Infection
- Trial name
- NCT07196306
- Testing
- Sarilumab 200 MG/1.14 ML Subcutaneous Solution
- Where
- 3 sites in United States
- Sponsor
- BayCare Health System
Breast Implantation
Retrospective Study of Incidence and Etiology of Reoperation After Primary Augmentation With Natrelle® Breast Implants
Retrospective multi-center, post-marketing study to evaluate the incidence and etiology of reoperations with Allergan Natrelle® Breast Implants in primary augmentation (RANBI)
- Trial name
- RANBI (NCT02132572)
- Testing
- BIOCELL™ Textured 410 Implant
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 201 people
- Sponsor
- Allergan
Pneumonia, Cardiovascular Disease (CKD)
Alteration of the Risk of CArdiovascular DIseases After Pneumonia
Pneumonia can be acquired in the community (CAP) or during hospitalization (HAP). It is a leading cause of communicable diseases and the second cause of disability-adjusted life-years in the world (Roquilly et al., Shankar-Hari…
- Trial name
- ARCADIA (NCT07357116)
- Where
- France
- Volunteers
- 2,000,000 people
- Sponsor
- Nantes University Hospital
Infertility, Intrauterine Adhesions
Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells
Study of the treatment of infertility caused by severe intrauterine adhesions or endometrial dysplasia by collagen scaffold loaded with autologous bone marrow stem cells, and to provide clinical evidence for the treatment of…
- Conditions
- Infertility, Intrauterine Adhesions, Endometrial Dysplasia
- Trial name
- NCT02204358
- Testing
- autologous bone marrow stem cells
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Anemia
A Study to Determine the Safety and Effectiveness of Epoetin Alfa Versus Placebo in Patients With Persistent Anemia Caused by Advanced Cancer
The purpose of this study is to determine the safety and effectiveness of epoetin alfa versus placebo, injected beneath the skin, in the treatment of patients with persistent anemia caused by advanced cancer, with a below normal…
- Trial name
- NCT00269984
- Testing
- Epoetin alfa
- Volunteers
- 56 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Febrile Illness
Evaluation of the DPP II Assay in Laos
Fever is the most frequent symptom in patients seeking care globally. Several causative agents of febrile illness have been described with a high prevalence in South East Asia.
- Trial name
- NCT04299607
- Testing
- DPP Fever Panel II assay and DPP Micro Readers
- Where
- Laos
- Volunteers
- 300 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Gastric Ulcers Duodenal Ulcers Caused by Low-dose Aspirin
Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study)
The primary objective of this study to examine the long-term safety of rabeprazole 5 mg or 10 mg tablets administered once daily in participants who were confirmed to have no recurrence of gastric or duodenal ulcer by endoscopic…
- Trial name
- NCT01398410
- Testing
- Rabeprazole
- Where
- 50 sites in Japan
- Volunteers
- 405 people
- Sponsor
- Eisai Co., Ltd.
Choroideremia
Gene Therapy for Blindness Caused by Choroideremia
Primary objective: To assess the safety and tolerability of the AAV.REP1 vector, administered at two different doses to the retina in 12 patients with a diagnosis of choroideremia.
- Trial name
- NCT01461213
- Testing
- rAAV2.REP1
- Where
- 4 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Oxford
Acute Liver Failure, Hepatic Encephalopathy
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
We have completed patient enrollment in the the double blind, randomized, placebo-controlled trial of intravenous (IV) N-acetylcysteine (NAC) vs. placebo for the treatment of non-acetaminophen ALF.
- Trial name
- NCT00248625
- Testing
- N-acetylcysteine
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 184 people
- Sponsor
- University of Pittsburgh
Rare Diseases, Genetic Disease
Functional Study to Indentify Genetic Etiology of Rare Diseases - ORIGIN
Next generation sequencing (NGS) allows some better diagnostic results, particularly, in the rare diseases field. At a twenty five percent rate, those exams highlight some variants which are not yet described in human pathology.
- Trial name
- ORIGIN (NCT05499091)
- Testing
- Skin biopsy, blood sample, urine sample
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Angers
Respiratory Syncytial Virus Infections
A Study to Learn About the Amount of the Study Medicine (Sisunatovir) in Blood and Its Safety in Infants and Children With Pneumonia Caused by RSV
The purpose of the study is to learn about the safety and amount of sisunatovir in the blood of infants and children up to age 60 months.
- Trial name
- NCT06102174
- Testing
- Active
- Where
- 9 sites in United States, Japan and 1 more
- Volunteers
- 10 people
- Sponsor
- Pfizer
Gingivitis
Evaluate Inflammation Caused by Gingivitis in Adults
The purpose of this study is to compare the anti-inflammatory efficacy of a dentifrice
- Trial name
- NCT00941668
- Testing
- Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
End Stage Renal Disease Patients
Causes Of End Stage Renal Disease In Patients Undergoing Regular Hemodialysis
CKD is defined as kidney damage for ≥3 months, as defined by structural and or functional abnormalities of the kidney, with or without decreased GFR or GFR <60 mL/min/1.73m2 for ≥3 months, with or without kidney damage.
- Trial name
- NCT03779750
- Testing
- s.creatinine
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Intraabdominal Infections
A Study of Levornidazole Disodium Phosphate for Injection vs. Ornidazole in Treatment of Postoperative Intra-Abdominal Infections Caused by Anaerobic Bacteria
Anaerobic infections are very common in clinical practice. Poor control of anaerobic infections in patients undergoing abdominal surgery may lead to the occurrence of complications.
- Trial name
- NCT06828874
- Testing
- Levornidazole Disodium Phosphate for Injection, Ornidazole and Sodium Chloride Injection
- Where
- 32 sites in China
- Volunteers
- 696 people
- Sponsor
- Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd
RSV Infections, Lower Respiratory Tract Infections
Real-World Effectiveness of Nirsevimab Against RSV-Related and All-Cause Respiratory Tract Infections in Chinese Infants
A multicenter, retrospective cohort study based on clinical data from seven tertiary hospitals in China will be undertaken. The study aims to evaluate the real-world effectiveness of Nirsevimab in preventing Respiratory Syncytial…
- Trial name
- NCT07382219
- Testing
- Nirsevimab
- Where
- 7 sites in China
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- Han Tongyan
Primary Biliary Cholangitis, PBC
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible…
- Trial name
- VANTAGE (NCT05050136)
- Testing
- Volixibat
- Where
- 130 sites in United States, Argentina and 13 more
- Volunteers
- 333 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Decrease of Proteinuria With H.P. Acthar Gel and Its Effects on Clinical and Podocyte Function
Experience With H.P. Acthar Gel Treatment of Patients With Nephrotic Syndrome/Proteinuria Due to Various Etiologies and Its Effect on Podocyte Function
Patients with proteinuria to start treatment with Acthar and watch a variety of clinical parameters with a goal of decreasing proteinuria between 50-100% over a period of nine months with every 3 months increasing the dose of…
- Trial name
- Acthar (NCT03644771)
- Testing
- Acthar
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Greater Boston Medical Associates
Bicuspid Aortic Valve
Identification of Genetic Causes of Bicuspid Aortic Valve Disease
BAVgenetics is a partnership between Investigators at Boston University, Brigham and Women's Hospital, and Massachusetts General Hospital dedicated to discovering the genetic causes of bicuspid aortic valve disease and associated…
- Trial name
- BAV Genetics (NCT01026571)
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Boston University
Panic Disorder
Genetic Causes of Panic Disorder
This study will try to identify genes that increase the risk of developing panic disorder-an anxiety disorder characterized by recurrent unexpected panic attacks-and that contribute to the abnormalities associated with it.
- Trial name
- NCT00083265
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- National Institute of Mental Health (NIMH)
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