Clinical trials: Aetiology
Systolic Heart Failure Stage D (Disorder), Mitral Regurgitation
The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation
Background: Severe systolic heart failure would be complicated with low cardiac output and high left ventricular filling pressure and the clinical presentations would be low blood pressure, poor peripheral perfusion, and…
- Trial name
- NCT04217135
- Testing
- evidence-based medications vs. high-dose hydralazine + evidence-based medications
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Kidney Cancer, Leukemia
Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors
RATIONALE: Glutamine may help lessen neuropathy caused by chemotherapy. It is not yet known whether glutamine is more effective than a placebo in treating neuropathy caused by vincristine.
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity
- Trial name
- NCT00365768
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Columbia University
Acute Respiratory Failure With Hypoxia
PEEP in Patients With Acute Respiratory Failure
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support.
- Trial name
- NCT04912960
- Testing
- Mechanical ventilation
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Jesus Villar
Diabetes
Association of C-reactive Protein-albumin-lymphocyte Index (CALLY) With All-cause Mortality in Diabetic Patients
Based on retrospective cohort data from 3,988 diabetic patients in the NHANES database, this study is the first to show a significant negative correlation between the CALLY index and all-cause mortality in diabetic patients, with…
- Trial name
- required (NCT06976359)
- Where
- China
- Volunteers
- 3,988 people, healthy volunteers welcome
- Sponsor
- Kunming Children's Hospital
Bowel Ischemia, Acute Bowel Ischemia / Infarction
Diagnosing Acute Onset Insufficient Intestinal Blood Flow (Bowel Ischemia) With a Novel CT Technique Called Dual-energy CT (DECT). This Observational Study Seeks to Evaluate Whether DECT Can Improve the Diagnosis of Bowel Ischemia and How the DECT Findings Correlate With Intraoperative Findings
The aim of this study is to evaluate the performance of dual-energy CT (DECT) in the diagnosis of acute bowel ischemia (ABI). ABI is a condition characterised by inadequate blood supply to portions of the intestine.
- Trial name
- NCT04561323
- Testing
- Dual-energy CT
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ischemic Stroke
Intensive Drug Therapy for Ischemic Stroke
To observe the safety and efficacy of intensive drug therapy for ischemic stroke patients.Patients with acute stroke caused by intracranial arterial stenosis (stenosis rate ≥70%) were enrolled and accept dual antiplatelet therapy…
- Trial name
- NCT05620615
- Testing
- Intensive Drug Therapy
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Cholecystectomy
Evaluation of Microbial Colonisation and Contamination Caused by the Transvaginal and Transabdominal Access for Cholecystectomy
Transvaginal hybrid procedures are of interest as an available NOTES procedure for the clinical routine. The gynaecologists' experiences and the available studies report on low morbidity related to the transvaginal access.
- Trial name
- NOBACT (NCT01078025)
- Testing
- Smear test vaginally, intraabdominally
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Cantonal Hospital of St. Gallen
Diphtheria, Pertussis
Study of Quinvaxem for Vaccination Against Diphtheria, Pertussis, Tetanus, Hepatitis B and Diseases Caused by Haemophilus Influenzae Type B
The aim of this study was to evaluate the immunogenicity and safety of the Quinvaxem vaccine (a liquid combination vaccine against diphtheria, tetanus, B. pertussis, hepatitis B and H. influenzae Type B).
- Conditions
- Diphtheria, Pertussis, Tetanus, Hepatitis B
- Trial name
- NCT01362517
- Testing
- Quinvaxem
- Where
- Vietnam
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Chronic Renal Failure of Unknown Cause
CKDu Treated With Intra-arterial Infusion of Autologous SVF Cells
This is an interventional study to treat 18 patients with chronic kidney disease of unknown cause (CKDu), formerly known as Mesoamerican nephropathy (MeN), with autologous adipose tissue-derived stromal vascular fraction (SVF)…
- Trial name
- NCT05154591
- Testing
- Adipose-derived stromal vascular fraction cells
- Where
- Nicaragua
- Volunteers
- 18 people
- Sponsor
- Samuel Vilchez, PhD
Prader Willi Syndrome, Obesity
Characterization of Transcriptional Regulators of Ghrelin Hormone Which Causes Genetic Obesity
The problem point of the Prader-Willi Syndrome (PWS) patient is the obesity which is intense and the plasma ghrelin level which increases unusual from the recently PWS patients was discovered.
- Trial name
- NCT01404624
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Vasomotor Symptoms Associated With Menopause, Hot Flashes
A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause
Researchers are looking for a better way to treat women who have hot flashes after women have been through the menopause. Hot flashes are caused by the hormonal changes that happen when a woman's body has been through the…
- Trial name
- OASIS-1 (NCT05042362)
- Testing
- Elinzanetant (BAY3427080)
- Where
- 99 sites in United States, Austria and 6 more
- Volunteers
- 396 people
- Sponsor
- Bayer
Pain, Healthy Volunteers
A Study to Learn About Whether BAYH006689 Causes Skin Irritation When Applied as a Topical Gel in Healthy Participants
Researchers are looking for a better way to treat muscle and joint pains. Researchers have seen that medicines which help reduce pain and inflammation could be safer when applied directly to the skin, called topical application…
- Trial name
- NCT06511973
- Testing
- Naproxen (BAYH006689), A solution of 0.9% Saline, A solution of 0.2% SLS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease
Prevalence of Undiagnosed Chronic Obstructive Pulmonary Disease Sufferers in the Region of Murcia
The purpose of this study is determine the prevalence of undiagnosed Chronic Obstructive Pulmonary Disease (COPD) in population served and with exposure to cigarettes in the Region of Murcia
- Trial name
- NCT01380470
- Where
- Spain
- Volunteers
- 1,052 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Infectious Disease
Observational Research on Infectious Disease Outbreaks and Difficult Cases of Unidentified Etiology in Indonesia
This observational study will investigate suspected infectious diseases of unknown etiology prospectively during outbreaks and at healthcare facilities, and retrospectively through historical samples where no etiology was ever…
- Trial name
- INA-ORCHID (NCT04339179)
- Where
- 19 sites in Indonesia
- Volunteers
- 185 people
- Sponsor
- Ina-Respond
All-Cause Mortality, Circulatory and Other Disease Mortality
Hyperthyroid Follow-Up Study
Background: Hyperthyroidism is a common disease. It is very common for women. It is usually treated with Radioiodine (I-131). Some people think that this might cause cancer, even many years later.
- Conditions
- All-Cause Mortality, Circulatory and Other Disease Mortality, Thyroid and Other Cancer Mortality
- Trial name
- NCT02989103
- Where
- United States
- Volunteers
- 35,593 people
- Sponsor
- National Cancer Institute (NCI)
Adolescent Idiopathic Scoliosis (AIS), Neuromuscular Scoliosis
UNderstanding the Causes Of Idiopathic Scoliosis Through the Longitudinal Analysis of Proteomic Markers: the UNCOIL Study
The goal of this observational study is to find clinical, demographic, and protein biomarkers that scoliosis progression (scoliosis curve increases) and/or differ between participants with scoliosis versus those without…
- Trial name
- UNCOIL (NCT07634627)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Lumbar Strain
Visceral Somatization and Low Back Pain.
This study aims to verify the significance of the inclusion of procedures of a comprehensive therapeutic approach according to Eastern techniques to classical physiotherapy and to find out whether these Eastern techniques can…
- Trial name
- NCT04694170
- Testing
- additional therapy, conventional physiotherapy
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Charles University, Czech Republic
Thrombocytosis in Children
Aetiology And Outcome Of Children With Thrombocytosis Admitted to Assiut University Children Hospital
The primary Aim :to determine the etiology of thrombocytosis in children and frequency, outcome of thrombocytosis in Children.
- Trial name
- NCT06341036
- Volunteers
- 42 people
- Sponsor
- Assiut University
Breakthrough Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
Fosaprepitant Dimeglumine in Treating Patients With Nausea and Vomiting Caused By Chemotherapy
RATIONALE: Antiemetic drugs, such as fosaprepitant dimeglumine, may help lessen or prevent nausea and vomiting in patients treated with chemotherapy.
- Trial name
- NCT01031953
- Testing
- fosaprepitant dimeglumine, systemic chemotherapy, survey administration
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- OHSU Knight Cancer Institute
Cytotoxic Drugs, Romiplostim N01
Romiplostim N01 in the Treatment of Thrombocytopenia Caused by Cytotoxic Drugs in Breast Cancer Patients
The primary study objective: To evaluate the efficacy of romiplostim (N01) in the treatment of chemotherapy-induced thrombocytopenia (CIT) in breast cancer patients by assessing the proportion of patients whose platelet count…
- Conditions
- Cytotoxic Drugs, Romiplostim N01, Breast Cancer
- Trial name
- NCT07162519
- Testing
- romiplostim N01
- Volunteers
- 68 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
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