Clinical trials: Affective Disorder
Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder
Effects of Early Abuse on Adult Intimate Relationships
This study is designed to help us better understand the factors that affect the sexual lives of women who have been sexually mistreated during childhood.
- Conditions
- Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder, Female Orgasmic Disorder, Major Depressive Disorder
- Trial name
- NCT01803802
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Childhood Trauma, Major Depressive Disorder
HPA Axis Activity Due To Early Traumatic Stress and Metabolic Symptoms
This study evaluates the association between early trauma, depression and metabolic symptoms.
- Trial name
- Cort-Metab (NCT02398877)
- Testing
- stress
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Major Depressive Disorder, Anhedonia
Kappa Opioid Receptor Imaging in Depression (KOR Depression)
The purpose of this study is to use positron emission tomography (PET) imaging to measure the activity of the kappa opioid receptor (KOR) in the brains of depressed and non-depressed individuals.
- Trial name
- NCT02236702
- Testing
- Positron Emission Tomography (PET) imaging
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Postnatal Depression
LTP+CaCBT for Treating Postnatal Depression and Improving Child Wellbeing in Jos Nigeria
The project aims to test the feasibility, acceptability, cultural appropriateness and effectiveness of LTP+CaCBT for treating postnatal depression and to enhance the mental health and wellbeing of mothers and their children in…
- Trial name
- LTP+CaCBT (NCT04644081)
- Testing
- LTP, CaCBT, TAU
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Mental Health Issue, Anxiety Disorders
Culture and Well-being: Art as Prescription Therapy ("Art on Prescription")
Stratified randomised controlled trial with two arms: arts intervention (any of the arts interventions, see list), which we call here Active Group (AG) vs waitlist control (WL).
- Conditions
- Mental Health Issue, Anxiety Disorders, Depressive Disorder, Emotional Disorder
- Trial name
- AoP (NCT06361667)
- Testing
- Arts
- Where
- Greece
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- KAVADIA ELENI
Major Depression, Bipolar Disorder
Assessing the Impact of Self-directed Care, Within a Medicaid-funded Environment,on Participation and Community Living
This project proposed to demonstrate the effectiveness, costs, and benefits to participation and community living self-directed care programming within a financially sustainable Medicaid managed care environment.
- Conditions
- Major Depression, Bipolar Disorder, Schizophrenia
- Trial name
- NCT02520024
- Testing
- self-directed care
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Temple University Collaborative on Community Inclusion
Schizophrenia, Depression
Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses
This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses.
- Conditions
- Schizophrenia, Depression, Bipolar Disorder, Anxiety Disorders
- Trial name
- NCT00458094
- Testing
- Physical activity intervention with peer support (PA+PS), Physical activity intervention without peer support (PA)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postpartum Depression, Quality of Life
Whether Probiotics Use in Neonate and Infant Improve Their Mother's Life Quality
Postpartum depression and poor quality of life during postpartum were an vital issue in recent years. Infant's health condition was thought to be a possible reasons related mother's postpartum quality of life, and functional…
- Conditions
- Postpartum Depression, Quality of Life, Functional Gastrointestinal Disorders, Probiotics
- Trial name
- NCT04741971
- Testing
- Probiotics group, Non-probiotics group
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Bipolar Depression
A First In Human Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of PF-04455242 In Single Rising Doses In Healthy Adult Volunteers
The purpose of this first in human (FIH) study is to investigate the safety, tolerability, pharmacokinetics ( how the body handles the drug) and pharmacodynamics (how the drug affects the body) of PF-04455242-01 in healthy adult…
- Trial name
- NCT00938301
- Testing
- PF-04455242
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy, Mood Disorder
Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects
St. John's Wort is a popular dietary supplement that many people take to elevate mood or relieve stress. This study will test in normal volunteers whether this preparation may alter mood and if so, by what means.
- Trial name
- NCT00001919
- Testing
- Hypericum (LI-160)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Depression
Investigating Predictors of Treatment Response in Treatment-Resistant Depression (TRD) With Interleaved TMS/fMRI
The purpose of this trial is identify biomarkers of response to repetitive transcranial magnetic stimulation (rTMS) in individuals with first episode or treatment resistant depression.
- Trial name
- NCT03642522
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Major Depressive Disorder
Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder
Study hypothesis: psychotherapy and SSRI treatment effect in different brain way: psychotherapy in "up to down" way and SSRI in "down to up" way.
- Trial name
- NCT01460212
- Testing
- SSRI antidepressants, Cognitive-Behavior Therapy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Pregnancy, Breastfeeding
The Effect of Early Versus Traditional Follow-Up on Breastfeeding Rates at 6 Months
The study's purpose is to determine if early (2-3 week) versus traditional (6-8 week) postpartum follow up is associated with a higher rate of breastfeeding at 6 months.
- Conditions
- Pregnancy, Breastfeeding, Contraception, Cervical Cancer
- Trial name
- NCT02221895
- Testing
- Postpartum follow up appointment 2-3 weeks after delivery, Postpartum follow up 6-8wk after delivery
- Where
- United States
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Schizophrenia, Schizo Affective Disorder
Peripheral Immune System in Individuals With Schizophrenia
The investigators are seeking healthy volunteers and people with schizophrenia or schizoaffective disorder for a clinical study of the immune system in psychotic disorders.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT05109065
- Testing
- SCID (Standardized Clinical Interview for DSM-V), PSS (Perceived Stress Score), Urine Toxicology Screen
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
Schizophrenia
A Bioequivalence Study of 15 mg ER OROS Paliperidone
The purpose of this study is to evaluate the bioequivalence between the Phase 3 and the to-be-marketed formulations of extended release (ER) OROS paliperidone and to evaluate the effect of food on the highest to be marketed…
- Trial name
- NCT00892489
- Testing
- ER OROS Paliperidone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Major Depressive Disorder
Identifying Biological Markers for Severe Depression
The primary objective of this study is to investigate the biological components of major depression. The investigators are particularity interested in genetic variation and how it contributes to cortisol (because cortisol is…
- Trial name
- NCT01831882
- Where
- 3 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postpartum Depression (PPD), Pregnancy
Clinical Validation of a Predictive Test for Postpartum Depression
The goal of this observational study is to develop a blood test that may be predictive of postpartum depression. This Blood test is investigational and not yet FDA approved.
- Trial name
- PREVAIL (NCT06831968)
- Testing
- Enlighten
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Psychosis;Schizophrenic, Personality Disorders
The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology
The outbreak of the SARS-CoV-2 pandemic may be considered a traumatic phenomenon. In a sample of subjects suffering from different psychiatric disorders, psychopathological status and Post-Traumatic Stress Disorder (PTSD)…
- Conditions
- Psychosis;Schizophrenic, Personality Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT04694482
- Testing
- Psychometric scale administration
- Where
- Italy
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Panic Disorder, Posttraumatic Stress Disorder
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder
The purpose of this study is to examine how certain brain chemicals work in patients with Panic Disorder (PD) and Post-Traumatic Stress Disorder (PTSD) with and without major depressive disorder (MDD).
- Conditions
- Panic Disorder, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00025974
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
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