Clinical trials: Affective Disorder
Depressive Disorder and Anxiety Disorders
A Study To Investigate Effects Of GSK561679 On Brain Activation During Emotional Processing In Healthy Volunteers
This study will be conducted in healthy volunteers to investigate the effect of single dose GSK561679 on the changes of brain activation, as it compares to an active comparator, lorazepam.
- Trial name
- NCT00513565
- Testing
- single dose
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bipolar Disorder
Identification of Predictive Biomarkers of Mood Relapses in Patients With Bipolar Disorder
Relapses in bipolar disorders are associated with a significant proportional functional impact, as well as worsening of the course of bipolar disorder, with impairment of the quality of functional remission, as well as the…
- Trial name
- Predibip (NCT04703972)
- Testing
- clinical assessment (mood relapses identification)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Mood Disorders, Anxiety Disorders
Online Training for Addressing Perinatal Depression
The study team is developing an e-learning course to train obstetric providers to address perinatal mood and anxiety disorders. The study team will conduct a formative evaluation of the e-learning course with 10 obstetric…
- Trial name
- NCT04919967
- Testing
- Virtual implementation protocol, e-learning toolkit
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Post-partum Depression
Mobile Application in the Management of Mild to Moderate Postpartum Depression (PPD)
Primary Objective: Evaluate the user experience with the Stella (TM) app for the management of Postpartum Depression in an observed population for 8 calendar weeks.
- Trial name
- NCT05077644
- Testing
- Stella (TM) Mobile Application
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Curio Digital Therapeutics, Inc.
Major Depression
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET
This study aims at evaluating the effect of electroconvulsive therapy in treatment-resistant depressed patients on the major serotonin degrading enzyme in the human brain using neuroimaging methods, the monoamine oxidase A.
- Trial name
- NCT02379767
- Testing
- Electroconvulsive therapy, Positron emission tomography of the brain using [11C]harmine, Structural magnetic resonance imaging
- Where
- Austria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Depression, Schizophrenia
Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms
The aim of the study is the examination of brain plasticity on on affective symptoms after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback.
- Trial name
- APIC-II (NCT03183947)
- Testing
- fMRI, Neurofeedback, PANAS
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Bipolar Disorder
Aripiprazole in the Treatment of Bipolar Depression
A systematic open-label prospective pilot study to assess aripirazole for acute bipolar depression, with a secondary assessment of longer-term mood stabilization.
- Trial name
- NCT00226317
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Healthy, Substance-related Disorder
Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study
The purpose of this study is to investigate effects of methylphenidate, modafinil, and 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on emotion-processing and cognitive performance using functional magnetic resonance…
- Conditions
- Healthy, Substance-related Disorder, Mood Disorder
- Trial name
- NCT01951508
- Testing
- Methylphenidate, Modafinil, MDMA
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Seasonal Affective Disorder
Study of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder
The investigators are looking for volunteers who have a history of Major Depressive Disorder, the Winter Blues, or Seasonal Affective Disorder or healthy volunteers who do not have a history of these disorders for a research…
- Trial name
- Season605 (NCT01292889)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Schizophrenia
A Study of Paliperidone Enantiomer Disposition With Different Formulations and the Bioavailability of Immediate- and Extended-release Paliperidone
The purpose of this study is to characterize the pharmacokinetics of paliperidone in plasma and urine after intravenous (i.v.) administration of the racemate, administration of the immediate-release (IR) racemate oral solution…
- Trial name
- NCT00796276
- Testing
- IR OROS paliperidone and ER OROS paliperidone
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Relation, Mother-Child, Family Conflict
Children's Learning Centers Group FNI
The purpose of this study is to compare the effects of Family Nurture Intervention in a mother-child group setting with a Standard Children's Learning Center (CLC) Program for preschool-aged children (ages 2-4.5).
- Conditions
- Relation, Mother-Child, Family Conflict, Emotional Disturbances, Behavior Problem
- Trial name
- NCT03908268
- Testing
- Family Nurture Intervention (FNI), Standard Children's Learning Center (CLC) Program
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Columbia University
Psychological Distress, Pregnancy Related
Mindful Moms: Mechanisms of Mindfulness-based Cognitive Therapy During Pregnancy and Postpartum
The proposed study seeks to elucidate the mechanisms underlying Mindfulness-Based Cognitive Therapy in pregnancy to improve understanding of how and why this treatment modality enhances well-being, which can then be leveraged to…
- Conditions
- Psychological Distress, Pregnancy Related, Postpartum Blues, Postpartum Depression
- Trial name
- NCT05137925
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depression, Postpartum
Determining the Effect of Telephone Counseling Service Provided to Primiparous Mothers on Postpartum Depression
The aim of this study is to determine the effect of telephone counseling services provided to primiparous mothers on postpartum depression.
- Trial name
- NCT06070168
- Testing
- Telephone Counseling
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Bipolar Disorder
Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders
This is a single center, open prospective study to evaluate the effectiveness of quetiapine monotherapy in the maintenance treatment of adolescent patients with a bipolar spectrum disorder (bipolar I and bipolar II disorders…
- Trial name
- NCT00252226
- Testing
- Quetiapine
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mood Disorders Center of Ottawa
Depression, Postpartum Depression
Effectiveness of a Web-based Prevention Program for Postpartum Depression
The original trial will evaluate the effectiveness of a Web-based program in preventing postpartum depression. The site has been modified to provide materials from both conditions.
- Trial name
- NCT00816725
- Testing
- Mothers and babies Internet course and PPD informational brochure
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depressive Disorder and Anxiety Disorders
To Investigate Effects GSK561679 on Part of the Body's System That Controls the Balance of Many of the Hormones.
A study to investigate the effects GSK561679 on part of the body's system that controls the balance of many of the hormones (including cortisol).
- Trial name
- NCT00426608
- Testing
- metyrapone, alprazolam, GSK561679
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Schizophrenia
A Study of the Effect of Food and Posture on the Pharmacokinetics of a Single Dose of ER OROS Paliperidone
The purposes of this study are to evaluate the effect of food on the pharmacokinetics of extended-release (ER) OROS paliperidone in healthy men, and to evaluate the effect of posture on the pharmacokinetics of ER OROS…
- Trial name
- NCT00838669
- Testing
- Extended release OROS paliperidone
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Major Depressive Disorder
A Study to Measure if There is Any Difference in How the Body Breaks Down or Inactivates Either Fluoxetine or LY2216684 When Both of These Medicines Are Given Together.
The purpose of this study is to measure if there is any difference in how the body breaks down or inactivates either fluoxetine or LY2216684 when both of these medicines are given together.
- Trial name
- NCT01243957
- Testing
- LY2216684, Fluoxetine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Bipolar Disorder
The STAGE Study for Bipolar Disorder
When the investigators are caught up in emotions, it is by stepping back (or decentering) that the investigators are able to see the situation from another perspective.
- Trial name
- NCT02597686
- Testing
- SD-PB training
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
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