Clinical trials: Affective Disorder
Depressive Symptoms, Clinical Depression
Improving Mood in Assisted Living Settings
Late-life depression levels are escalating, and include 24% of all tenants of Assisted Living (AL) settings. A promising, novel intervention is a computerized visual speed of processing training program known as Road Tour.
- Trial name
- NCT01763216
- Testing
- Road Tour, Boatload of Crosswords
- Where
- 32 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Marianne Smith
Major Depressive Disorder
The Antidepressant Advisor (Study 3): fMRI Study to Predict Treatment Response in Patients With Depression
This prospective observational study (ADeSS-Study3) investigates candidate biomarkers prospectively predicting response to antidepressant medications and prognosis in major depressive disorder (MDD).
- Trial name
- ADeSS_S3 (NCT04342299)
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King's College London
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)
MDMA (3,4-Methylenedioxymethamphetamine, "Ecstasy") produces tachycardia, hypertension, hyperthermia, and other acute adverse effects. Ecstasy use has also been associated with rare cardio- and cerebrovascular complications.
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT00895804
- Testing
- MDMA, Pindolol
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Affective Spectrum Symptoms
Gene-environment Interactions in Families With Adolescents (Gen-omgevingsinteracties in Gezinnen Met Adolescenten)
English: The main purpose of this study is to investigate the developmental trajectories of parents and adolescents in the Flemish region of Belgium.
- Trial name
- GiGA (NCT05716412)
- Where
- 2 sites in Belgium
- Volunteers
- 1,326 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Subjects, Depressive Disorder
GSK372475 Bioequivalence Study
The study is to show the new salt formulation of GSK372475 is equivalent to the old salt formulation of GSK372475.
- Trial name
- NCT00488098
- Testing
- GSK372475
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Perinatal Depression, Perinatal Anxiety
Prospective Study Evaluating a Novel Mobile App Based Preventive Behavioral Intervention for Perinatal Mood Disorders
The primary aim of the study is to investigate whether a novel mobile App-based behavioral intervention in pregnant women can: (1) prevent and/or decrease the incidence of perinatal mood disorders (2) decrease the severity and/or…
- Trial name
- NCT04914299
- Testing
- App-based "positive intelligence" intervention, Standard of care
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Major Depression
Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
The purpose of the study is to find out what parts of the brain have increased or decreased activity and connectivity in individuals who have bipolar disorder, major depression, or no history of mood disorder.
- Trial name
- NCT01811147
- Testing
- Selective Serotonin Reuptake Inhibitor (SSRI)
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Major Depressive Disorder
Efficacy of Cranial Electrotherapy Stimulation (CES) for the Treatment of Major Depressive Disorder
Efficacy of Cranial Electrotherapy Stimulation (CES) for the treatment of Major Depressive Disorder
- Trial name
- NCT03222752
- Testing
- Cranial Electrotherapy Stimulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Electromedical Products International, Inc.
Depression, Anxiety Disorders
Focused Ultrasound Amygdala Neuromodulation
The purpose of the study is to examine the feasibility and potential efficacy of low-intensity focused ultrasound as a method of modulating amygdala function to promote improvements in symptoms of an affective disorder.
- Conditions
- Depression, Anxiety Disorders, Bipolar Depression, Ptsd
- Trial name
- NCT05228964
- Testing
- Focused ultrasound
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Depression, Postpartum
Validation of the French Version of the Edinburgh Postnatal Depression Scale (EPDS) Postnatally in the Father
In recent years, fatherhood has changed considerably. Fathers are now more involved during the perinatal period, with their partner but also in caring for the child.
- Trial name
- EPDS-PERE (NCT06772701)
- Testing
- Mini International Neuropsychiatric Interview, EPDS book
- Where
- 2 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Major Depressive Disorder
A Study of the Effect of LY2216684 on Lorazepam
The purpose of this study is to determine how much lorazepam gets into the blood and how long it takes the body to get rid of it when given together with LY2216684.
- Trial name
- NCT01275144
- Testing
- LY2216684, Lorazepam
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Bipolar Disorder I or II, Healthy (Controls)
Decoding Emotional Dynamics in Bipolar Disorder
The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability.
- Trial name
- NCT07221864
- Testing
- Think and Regulate Affective State Task
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Major Depressive Disorder
Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.
30 healthy adults and 30 patients with major depressive disorder, will take part in three single-application pharmacological interventions (GHB vs. Trazodone vs.
- Trial name
- NCT04082806
- Testing
- GHB, Trazodone
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Erich Seifritz
Major Depressive Disorder (MDD)
The Effects of Dopamine on Reward Processing
The purpose of this study is to evaluate the effects of a single low dose of the D2/D3 antagonist amisulpride on reward processing.
- Trial name
- NCT01253421
- Testing
- amisulpride
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Apathy, Bipolar Disorder
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
The goal of this clinical trial is to identify reliable markers of apathy in elderly subjects with bipolar disorder, age between 70 and 85 years, in order to accurately identify subjects at high risk of progressing to dementia by…
- Trial name
- ANACONDA (NCT06914284)
- Testing
- Actigraphy and MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Major Depressive Disorder
Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR)
Selective serotonin reuptake inhibitors (SSRIs) raise serotonin (5-HT) in the synaptic cleft and are the current first line of pharmacological antidepressive treatment.
- Trial name
- NCT02711215
- Testing
- PET/MR [11C]DASB, Citalopram, Escitalopram (Mirtazapine/Duloxetine/Venlafaxine)
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Major Depressive Disorder
Enhancing Psychotherapy for Mood Disorders With Whole Body Hyperthermia
According to the 2005 National Comorbidity Survey-Replication study, approximately 20.9 million American adults, or 9.5 percent of the population over the age of 18 suffer from mood disorders including major depressive disorder…
- Trial name
- NCT02021149
- Testing
- High intensity whole-body infrared heating, Psychotherapy, Questionnaires
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Charles (Chuck) Raison
Major Depressive Disorders, Senile; Depression
Health Care Management for the Elderly in Community Through Screening
Depression in late life has been associated with losses in functioning and quality of life, mortality, and increased health care costs.
- Trial name
- NCT01347138
- Testing
- case management
- Where
- South Korea
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Clinical Research Coordination Center, Seoul, Korea
Baby Massage, Postpartum Depression
The Effect of Baby Massage Training Given to Pregnant Women on Maternal Attachment and Postpartum Depression
The research to be conducted within the scope of the project will be randomized controlled, and the population of the research will be primiparous pregnant women reached through social media.
- Trial name
- NCT06136520
- Testing
- Baby massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
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