Clinical trials: Affective Disorder
Depression, Bipolar Disorder
Prevention of Mood Disorders by Folic Acid Supplementation
The purpose of this study is to determine whether daily folic acid supplements can prevent new episodes of mood disorder in young people (aged 14-24 years) of biological parents with current or past history of depression or…
- Trial name
- PRE-EMPT (NCT00459264)
- Testing
- Folic Acid
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Seasonal Affective Disorder
Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET
This study aims to assess differences in monoamine oxidase A (MAO-A) distribution in the brain between seasonal affective disorder patients and healthy controls using positron emission tomography.
- Trial name
- NCT02582398
- Testing
- Light Therapy
- Where
- Austria
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Major Depressive Disorder
5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females
The investigators hypothesize that the administration of two widely available, naturally occurring dietary supplements, 5 hydroxytryptophan and creatine monohydrate, will reduce the severity of depression in individuals exposed…
- Trial name
- NCT02356107
- Testing
- 5-hydroxytryptophan and Creatine monohydrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Major Depressive Disorder, Bipolar Disorder
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
This study evaluates the efficacy of sleep deprivation treatment in accelerating antidepressant responses when administered during the first week of medications and augmenting a sustained response with chronobiological…
- Trial name
- NCT00581009
- Testing
- chronobiological augmentation, sertraline, lithium, one night of sleep deprivation and two FDG PET scans
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Schizophrenia, Bipolar Disorder
Resting State Electroencephalogram for Psychotic Disorders
Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. Meanwhile, the increased appetite, which might related to self-control process, has been an increasing concern for…
- Conditions
- Schizophrenia, Bipolar Disorder, Depression
- Trial name
- NCT05065489
- Testing
- No intervention
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Central South University
Major Depressive Disorder
PET Biomarkers in Treatment Resistant Depression
The primary objectives of the study are to test whether brain Mono Amine Oxidase-A (MAO-A) levels are elevated in patients with treatment-resistant major depression, and to explore whether MAO-A brain levels predict treatment…
- Trial name
- NCT01031810
- Testing
- tranylcypromine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder
Safety And Efficacy Of Ziprasidone In Children And Adolescents With Bipolar I Disorder (Manic Or Mixed) (Protocol A1281196)
The purpose of this study is to determine if flexibly-dosed ziprasidone is safe and effective for the treatment of children and adolescents (ages 10-17) with Bipolar l Disorder (Manic or Mixed).
- Trial name
- NCT01117220
- Testing
- Ziprasidone Oral Capsules
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Alcohol Related Disorders, Substance Related Disorders
The Co-Venture Trial: A Cluster Randomized Trial of Personality-targeted Interventions on Adolescent Substance Use and Cognitive Outcomes
The Preventure Program is the first and only school-based alcohol and drug prevention program that has been shown to prevent onset and growth in alcohol and substance misuse in British and Canadian youth.
- Trial name
- NCT01655615
- Testing
- Preventure programme
- Where
- Canada
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Psychotic Disorders, Autism Spectrum Disorder
EEG Microstates Across At-Risk Mental States
The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6).
- Conditions
- Psychotic Disorders, Autism Spectrum Disorder, Major Depressive Disorder, Schizophrenia
- Trial name
- DEMETER (NCT06045897)
- Testing
- EEG 64 channels, Polysomnography 19 electrodes, Light hypnosis
- Where
- France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Autism Spectrum Disorder, Depression
TMS for Adults With Autism and Depression
The goal of this proposal is to investigate whether a standard rTMS protocol for depression, including multiple sessions applied to left dorsolateral prefrontal cortex (DLPFC) results in reduction of depressive symptoms for adult…
- Conditions
- Autism Spectrum Disorder, Depression, Depressive Disorder, Major Depressive Disorder
- Trial name
- TAD (NCT02939560)
- Testing
- NeuroStar® TMS device (Neuronetics, Atlanta, GA)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder
Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter…
- Trial name
- PRS (NCT02440815)
- Testing
- Problem Solving Therapy
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
Effects of Ghrelin Administration on Dopamine and Effort
Ghrelin is a stomach-derived hormone and the only known circulating peptide that stimulates appetite. Animal studies have conclusively shown that ghrelin increases dopaminergic neurotransmission and, thereby, enhances effort.
- Trial name
- NCT05318924
- Testing
- Ghrelin
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder (MDD), Rumination
Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole
This randomized, single-blind (assessor-blind) controlled trial aims to investigate the efficacy of aripiprazole as an augmentation strategy for treating pathological rumination in patients with major depressive disorder (MDD).
- Trial name
- NCT06937476
- Testing
- Escitalopram, Aripiprazole 5mg
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Central South University
Major Depressive Disorder
Imaging Neural Correlates of Ketamine Using PET/MR
The purpose of this randomized, placebo-controlled study is to investigate pharmacodynamic differences between racemic ketamine and esketamine using functional fluorodeoxyglucose ([18F]FDG) positron emission tomography/magnetic…
- Trial name
- RSKet (NCT04587778)
- Testing
- Ketamine Hydrochloride, Esketamine, Pilot study II: Esketamine
- Where
- Austria
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Postpartum Depression, Mother-Infant Interaction
Mobile-Based Exercise in Postpartum Period
Postpartum depression is a global mental health problem affecting 13 million women worldwide each year. It is defined as minor or major depression that occurs up to one year after birth and is estimated to affect 5 to 25% of…
- Trial name
- NCT06390540
- Testing
- Exercise
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara University
Clinical Trial
tDCS as Adjunctive Therapy to Cognitive Stimulation in Medical Students With Depression
Major depressive disorder (MDD) is a major public health problem, it negatively affects cognition and cognitive deficits affect information processing speed, attention, memory, executive function and working memory.
- Trial name
- NCT06562387
- Testing
- transcranial direct current stimulation, cognitive stimulation
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Seasonal Affective Disorder
Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder
As the seasons change during the course of the year, many animals show major changes in their behavior and physiology. Many of these changes are triggered by changes in the length of time each night that the pineal gland produces…
- Trial name
- NCT00001485
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
MRI Studies of Emotion in Depression
The purpose of this study is to research the effects of ketamine on brain function in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT02429011
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postpartum Depression
Implementation of a Clinical Decision Support Tool for Postpartum Depression
This study will evaluate the use of an automated process in the electronic health record (EHR) that will help providers to detect patients at risk of developing postpartum depression (PPD).
- Trial name
- CDS (NCT06818734)
- Testing
- Clinical Decision Support Tool
- Where
- 4 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Remotely Non-invasive Brain Stimulation and Videogame to Alleviate Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; up to 40% of patients do not benefit sufficiently from existing antidepressant interventions including trials…
- Trial name
- NCT04953208
- Testing
- active tDCS, cognitive and emotional control video game
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Mor Nahum
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