Clinical trials: Affective Disorder
Postpartum Depression
Quetiapine Versus Trazadone in Women With Postpartum Depression
Postpartum depression is a serious disorder that affects approximately 17% of women who have recently given birth. Untreated postpartum depression can negatively affect the mother, the infant, and the family.
- Trial name
- NCT06546358
- Testing
- Trazodone, Quetiapine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bipolar Disorder
Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)
The investigators aim to examine the effect of the ketogenic diet on brain activity, metabolism, and emotions in adults with Bipolar Disorder (BD).
- Trial name
- NCT06081426
- Testing
- Non-ketogenic Diet, Ketogenic Diet, No diet
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depression, Healthy
Bone Loss in Premenopausal Women With Depression
The purpose of this study is to determine whether women with major depression lose bone mass at a faster rate than women without depression.
- Conditions
- Depression, Healthy, Osteopenia, Osteoporosis
- Trial name
- NCT00006180
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Psychotic Disorders, Cognitive Impairment
Cognitive Impairments in Psychotic Disorders
Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first…
- Trial name
- NCT05597579
- Testing
- DAPAR Tests (IQ equivalent test)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Treatment Resistant Depression
Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression
Study TRD subjects' resistance to at least 2 different antidepressants, we hypothesize that because of their significant depression and treatment resistant status they are most likely to exhibit BSMN pathway abnormalities.
- Trial name
- MAOI (NCT03109717)
- Testing
- Monoamine Oxidase Inhibitor (MAOI)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Kathryn O'Connor
Depressive Disorder, Major
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-911 in Healthy Subjects
This is a Phase 1, conventional, double-blind, placebo-controlled, single-center clinical study comprised of 2 segments (Segment 1 and Segment 2) in which single and multiple doses of SUVN-911 or placebo will be orally…
- Trial name
- SUVN-911 (NCT03155503)
- Testing
- SUVN-911
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Schizophrenia, Autism Spectrum Disorder
Cerebellar Stimulation and Cognitive Control
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
- Conditions
- Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression
- Trial name
- NCT03217110
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Krystal Parker, PhD
Mood Disorders, Depression
Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders
Stress-related disorders are among the most prevalent and expensive medical consequences of participation in military operations.
- Conditions
- Mood Disorders, Depression, Combat Disorders, Stress Disorders
- Trial name
- NCT01216982
- Testing
- Lovaza, omega-3 fatty acid ethyl ester
- Where
- Iraq
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Major Depressive Disorder
Games to Overcome Late Life Depression
This is a pilot study divided into two phases. IN phase 1 (completed) participants will be randomized to receive 8 weeks of Problem Solving Therapy (PST) alone or 8 weeks of a cognitive training game called, Evolution (Evo) plus…
- Trial name
- GOLD (NCT02229188)
- Testing
- Problem Solving Therapy, Evolution, Words
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington
Schizophrenia
Longitudinal Long-term Study (10 Years) of the Sample of First Episode of Non-affective Psychosis: PAFIP
Schizophrenia is a chronic brain disease that is still understood as a condition that limits the development of a normal life for the patient who suffers it and their families.
- Trial name
- 10PAFIP (NCT02200588)
- Where
- Spain
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Major Depressive Disorder, Suicide
Identifying the Neural Basis of Capability for Suicide
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system.
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation, Psychiatric Illness
- Trial name
- NCT03327129
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Depressive Disorder, Major
A Study to Evaluate Pharmacokinetics, Safety and Tolerability of Extended-release Bupropion Hydrochloride Tablets in Chinese Healthy Volunteers
Bupropion is used in psychological disorder mainly in major depressive disorder (MDD). In China, buproprion Immediate Release (IR) and Sustained Release (SR) tablet have been in market for the treatment of MDD.
- Trial name
- NCT02698553
- Testing
- Bupropion HCl XL tablet 150mg, Bupropion HCl XL tablet 300mg
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pregnancy Related, Pregnancy Complications
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs.
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk, Depression
- Trial name
- RISE (NCT05552053)
- Testing
- MWSH plus Candlelit Care, MWSH
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Major Depressive Disorder, Healthy
Sleep Modulation to Treat Depression
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need…
- Trial name
- NCT06443216
- Testing
- Auditory closed-loop stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Christoph Nissen
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depression
ESTIA: Computerized Intervention Targeting Cognitive Control Deficits in Depressed Adults
Project:EVO is a video-game based intervention that targets neural networks associated with cognitive control. The same networks have been implicated in poor treatment response in middle and older aged adults suffering from major…
- Trial name
- NCT02891564
- Testing
- Band Together, Control Mobile 3D video game
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Washington
Depression, Treatment Resistant Depression
Computational Psychiatric Approach to Depression
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression.
- Trial name
- NCT04189939
- Testing
- clinical assessments
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Lactation Suppressed, Cabergoline Adverse Reaction
Factors and Outcomes Associated With Postpartum Cabergoline Use
Cabergoline is frequently being requested by many postpartum women with a live newborn to suppress lactation. The aim of the study is to investigate which women desire such an intervention, and what side effects they are…
- Conditions
- Lactation Suppressed, Cabergoline Adverse Reaction, Postpartum DVT, Postpartum Depression
- Trial name
- NCT03965572
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
Molecular Mechanisms of Pharmacological Action, Depression
Citalopram and Self Emotional Processing
This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mental Disorder
- Trial name
- NCT04169230
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Breastfeeding, Exclusive, Mother-Infant Interaction
Proyecto BEBE: The Effect of Babywearing Education on Breastfeeding Exclusivity
To test the hypothesis that increased mother-infant physical contact affects the likelihood of mothers exclusively breastfeeding their child for the first six months of life, the investigators will randomly assign half of the…
- Conditions
- Breastfeeding, Exclusive, Mother-Infant Interaction, Postpartum Depression
- Trial name
- NCT04376021
- Testing
- Babywearing
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Nurturely
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