Clinical trials: Affective Disorder
Tobacco Dependence, Schizophrenia
The Appeal and Impact of E-cigarettes in Smokers With SMI
This study will evaluate behavioral and psychological appeal, toxicity, and effect of e-cigarettes on smoking behavior and nicotine addiction in chronic smokers with serious mental illness (SMI) who have failed to quit smoking.
- Conditions
- Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03050853
- Testing
- E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy
Study Evaluating the Pharmacokinetics of Venlafaxine ER and Desvenlafaxine SR in Healthy Subjects
The purpose of this study is to determine if the relative difference in PK between extensive metabolizers (EMs) and poor metabolizers (PMs) is the same with desvenlafaxine SR and venlafaxine ER when a single dose is administered.
- Trial name
- NCT00329186
- Testing
- desvenlafaxine SR, venlafaxine ER
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
PostPartum Depression
Curio Digital Therapy for the Treatment of Post-partum Depression
Primary Objective: Evaluate the clinical effectiveness of the MamaLift Plus app compared to control (digital sham plus treatment as usual) for the management of PPD in the observed population for a period of 9 calendar weeks.
- Trial name
- SuMMER (NCT05958095)
- Testing
- MamaLift Plus
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Healthcare Innovation Technology Lab
Depression, Major Depressive Disorder
Feasibility and Acceptability of a Healthy Nordic Diet Intervention in Depressed and Non-depressed Adults
In the future, we plan to conduct an 8-week diet intervention to investigate whether a healthy Nordic diet improves depression symptoms.
- Trial name
- NCT04731454
- Testing
- Control Diet (CD), Healthy Nordic Diet (ND)
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Breastfeeding, Exclusive, Fatigue
MBSR and NLP, Postpartum Breastfeeding and Depression
The postnatal period is a risky period in which mothers experience regressive and progressive changes and rapid biopsychosocial changes.
- Conditions
- Breastfeeding, Exclusive, Fatigue, Sleep, Postpartum Depression
- Trial name
- postpartum (NCT06628986)
- Testing
- MBSR, NLP, control
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aysegul Kilicli
Postoperative Pain, Cesarean Section
Effects of Nerve Blocks on Pain After Caesarean Section and Postpartum Depression
At the end of your cesarean section surgery, which is started by applying medication to the spinal cavity from your waist, pain medication will be applied between the relevant muscle and its covering from your lower abdomen or…
- Conditions
- Postoperative Pain, Cesarean Section, Postpartum Depression
- Trial name
- NCT06221280
- Testing
- Nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Post Partum Depression
Relationship-Based Intervention for Post-Partum Depression
A short term dyadic psychotherapy intervention for mothers with Post-Partum depression and their babies in the first year of life was developed.
- Trial name
- NCT04193462
- Testing
- Post-partum depression- Dyadic psychotherapy-, Post-partum depression- Psycho-educational therapy
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Interdisciplinary Center Herzliya
Pain, Acute, Pain, Chronic
Changes in Affective Pain Processing in Human Volunteers
The experience of pain is more than the conscious perception of nociceptive signals. Emotional and motivational aspects accompany pain, leading to its aversiveness and motivation for avoidance.
- Conditions
- Pain, Acute, Pain, Chronic, Low Back Pain
- Trial name
- NCT04280796
- Testing
- psychophysical tasks, cognitive task
- Where
- Switzerland
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- susanne becker
Bipolar Disorder, Cocaine Dependence
Valproate Efficacy in Cocaine-Bipolar Comorbidity
This proposal will test the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder.
- Trial name
- NCT00240110
- Testing
- Valproate, Lithium Carbonate
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression, Anxiety
Mood Lifters for Undergraduates
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate new research discoveries into prevention and care for psychosocial-based problems are urgently needed since the vast majority of people who…
- Conditions
- Depression, Anxiety, Mood Disorders, Mental Health Wellness 1
- Trial name
- ML-UP (NCT05684120)
- Testing
- Mood Lifters for Undergraduates
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Schizophrenia, Major Depressive Disorder
Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individuals
This study aims to screen and validate multi-scale bio-markers for early diagnosis and medication monitoring for early schizophrenia, including the genetic, neurobiochemistry, neuroimaging and eletrophysiological measures.
- Conditions
- Schizophrenia, Major Depressive Disorder, Anxiety Disorders
- Trial name
- NCT03790085
- Testing
- Risperidone, Olanzapine, Aripiprazole
- Where
- China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Major Depressive Disorder
Network Neurofeedback Using 7-Tesla MRI to Reduce Rumination Levels in Depression
Patients with major depressive disorder (MDD) exhibit increased levels of rumination (i.e. repetitive thinking and focus on negative mood states) which have been found to increase the risk of depressive relapse.
- Trial name
- NCT05933148
- Testing
- Siemens 7T MRI
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Blood Biomarkers in Major Depression
Depression is a leading cause of disability worldwide, affecting nearly 16% of the general population. Its physiopathology remains unclear.
- Trial name
- NCT02209142
- Testing
- blood prelevement, psychometric data collection
- Where
- France
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Physical Inactivity, Overweight or Obesity
eMOTION: Examining Affective Mechanisms in Physical Activity Engagement
This early-phase trial will test intervention strategies to influence affective mechanisms underlying physical activity and determine whether changes in those mechanisms result in change in physical activity behavior among…
- Conditions
- Physical Inactivity, Overweight or Obesity, Cancer
- Trial name
- NCT06570642
- Testing
- Physical Activity Goals mHealth Intervention, TYPE/CONTEXT enhancement, SAVOR enhancement
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Major Depressive Disorder
Safety, Tolerability and Pharmacokinetics Study of LY03005
The purpose of this study is to evaluate the safety and tolerability of escalating single oral doses of LY03005 in healthy subjects and to characterize the pharmacokinetics (PK) of escalating single oral doses of LY03005.
- Trial name
- LY03005SAD (NCT02055300)
- Testing
- LY03005, Meal, Pristiq
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Major Depressive Disorder
Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)
This study was a single-arm, non-randomized, open-label clinical study to assess dopamine transporter occupancy in the brain of healthy adults using 11C-CFT positron emission tomography (PET)
- Trial name
- NCT05905120
- Testing
- Toludivenlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Depressive Disorder
A Study To Evaluate The Effect Of WELLBUTRIN XL On Intraocular Pressure
This study will be conducted in healthy volunteers to investigate the effect on intraocular pressure of 2 weeks of treatment with 300mg WELLBUTRIN XL/day.
- Trial name
- NCT00439868
- Testing
- WellbutrinXL
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depressive Symptoms, Depressive Disorder, Major
Olfactory Training and Emotional State
During the past three decades, researchers have paid particular attention to the study of olfactory disorders in depression. Recent studies have shown that depression is characterized by a change in olfactory and emotional…
- Trial name
- ENOLFEA (NCT03605524)
- Testing
- Sensory training
- Where
- 3 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Postpartum Depression, Infant Development
Social Circumstances, Parenting Techniques, and Infant Development
1. Investigators aim to assess a novel behavioral intervention (currently approved in Protocol #6285) behavioral intervention that promotes maternally-mediated behavioral changes in young infants to reduce the risk of postpartum…
- Conditions
- Postpartum Depression, Infant Development, Rhythm; Sleep
- Trial name
- NCT02121496
- Testing
- Resources for Postpartum Parenting
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Postpartum Depression
Psychological Empowerment Program in Preventing Postpartum Depression Among Pregnant Women
The goal of this clinical trial is to prevent postpartum depression in pregnant women. The main questions it aims to answer are: 1.
- Trial name
- NCT07636005
- Testing
- Psychological Empowerment Program
- Where
- Indonesia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Miranie Safaringga
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