Clinical trials: Affective Disorder
Elderly, Exercise
The Effects of Green Exercise Program Consisting of 12-week Aerobic and Resistance Exercises on Sleep Quality, Alexithymia, Anxiety and Depression in Elderly People
The aim of this study is to investigate the effects of combination of aerobic and resistance exercises in the green exercise concept on depression, anxiety, alexithymia and sleep quality of elderly individuals.
- Trial name
- NCT05280249
- Testing
- both aerobic and resistance exercises in the green exercise concept
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Depressive Disorder
Paxil CR Bioequivalence Study Brazil
The study is prospective, open, randomized, crossover in steady state and the volunteers received multiple doses of the drug test and reference (two periods of drug administration).
- Trial name
- NCT01316926
- Testing
- Test formulation, Reference formulation
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bipolar Disorder
Ion Channel Genetic Biomarkers: Diagnostic Capabilities in the Assessment of Bipolar Disorder
Genotype 164 adults to evaluate six selected single nucleotide polymorphisms (SNPs) (rs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582) for use as a genetic biomarker to differentiate between bipolar depression…
- Trial name
- NCT03572426
- Testing
- genotyping all subjects
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder
Aripiprazole Augmentation of SSRI Therapy in Treatment Refractory Depression
Our target population will have been adequately treated with one of three selective serotonin reuptake inhibitors (SSRIs; escitalopram, citalopram, or sertraline) for at least 8-12 weeks and continue to experience symptoms of…
- Trial name
- NCT00608543
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Texas Southwestern Medical Center
Pediatric Bipolar Disorder
Invega (Paliperidone) for the Treatment of Mania in Children and Adolescents Ages 6-17 With Bipolar Disorder
This will be an 8-week open-label trial, using daily doses of paliperidone (Invega) in the treatment of children and adolescents who meet DSM-IV criteria of Bipolar I, Bipolar II, or Bipolar Spectrum Disorder.
- Trial name
- NCT00592358
- Testing
- paliperidone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Major
Duloxetine in the Treatment of Melancholic Depression
The purpose of this study is to determine the optimal treatment strategy for MDD patients with melancholic features who do not respond to a standard daily dose.
- Trial name
- NCT00191685
- Testing
- duloxetine
- Where
- 23 sites in Australia, Canada
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Substance-Related Disorders, Mood Disorders
Behavioral Activation for Heroin Use in China: A Randomized Controlled Trial
This was a single-site two-arm parallel-group trial conducted in a Methadone Maintenance Treatment (MMT) Clinic that provides medication service for 254 heroin users in Wuhan, China.
- Conditions
- Substance-Related Disorders, Mood Disorders, Behavioral Activation Treatment, Mental Disorders
- Trial name
- NCT03705143
- Testing
- Treatment as usual, Chinese translated LETS ACT
- Where
- China
- Volunteers
- 90 people
- Sponsor
- University of North Carolina, Chapel Hill
Postpartum Depression
A Descriptive Study of the Correlation Between Postpartum Depression and Body Image Dissatisfaction, Self-objectification, and Social Media Appearance Comparison
The goal of this observational study is to assess the prevalence of postpartum depression and analyze its relationship with body image dissatisfaction, self-objectification, and social media appearance comparison in postpartum…
- Trial name
- NCT07603063
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Depression
Determinants in Antidepressant Outcomes
This study is designed to understand if a biological measurement, of how platelets respond to serotonin (a chemical in the blood sometimes referred to as SERT), can provide information that will determine an "ideal dose," one…
- Trial name
- NCT00108316
- Testing
- Fluoxetine (Liquid Prozac)
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Bipolar Depression
Repetitive Transcranial Magnetic Stimulation for Treating Resistant Bipolar Depression
The aim of this randomized, single-blind trial is to evaluate the effectiveness and tolerability of high frequency or low frequency repetitive transcranial magnetic stimulation (rTMS) in patients with resistant bipolar…
- Trial name
- NCT01586793
- Testing
- Magstim Rapid2 Stimulator
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Douglas Mental Health University Institute
Diabetes Mellitus, Type 2, Severe Mental Disorder
Improving Diabetes Outcomes for People With Severe Mental Illness (SMI)
This study aims to identify the determinants of diabetes and to explore variation in diabetes outcomes for people with severe mental illness (schizophrenia, schizoaffective disorder and bipolar disorder) in order to develop…
- Trial name
- EMERALD (NCT03534921)
- Where
- United Kingdom
- Volunteers
- 46,564 people
- Sponsor
- University of York
Major Depressive Disorder, Healthy
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients
The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients.
- Trial name
- NCT00369798
- Testing
- PET scan, Rolipram
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Treatment-resistant Depression
A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression
The purpose of this open-label, multicenter study is to assess the long term safety and efficacy of intranasal esketamine plus an oral antidepressant in participants with treatment-resistant depression (TRD).
- Trial name
- SUSTAIN-2 (NCT02497287)
- Testing
- Esketamine (Intranasal Spray), Duloxetine (Oral Antidepressant), Escitalopram (Oral Antidepressant)
- Where
- 109 sites in United States, Argentina and 19 more
- Volunteers
- 802 people
- Sponsor
- Janssen Research & Development, LLC
Unipolar Depression, Bipolar Depression
Voice Changes During ECT
Depressed patients talk differently when they are depressed compared to when they are well. But it is hard to actually measure what the differences are.
- Conditions
- Unipolar Depression, Bipolar Depression, Bipolar Disorder, Manic
- Trial name
- VAPRE (NCT04420793)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Serious Mental Illness, Schizophrenia
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
Patients with severe mental illness (SMI) die younger than persons in the general population. Much of the excess mortality for SMI patients is attributable to cardiovascular disease, and is exacerbated by treatment with…
- Conditions
- Serious Mental Illness, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- FITNESS (NCT02188121)
- Testing
- Simvastatin, Losartan
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Insomnia
Brain Mechanisms and Targeting Insomnia in Major Depression
Preliminary studies suggest that the response to antidepressant medication can be accelerated by targeting insomnia with adjunctive use of eszopiclone.
- Trial name
- NCT00628914
- Testing
- escitalopram and eszopiclone, Escitalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Affective Disorder
Effectiveness of a Cognitive Remediation Intervention Based on Virtual Reality for Promotion of Cognitive Functioning and Participation in Daily Life Among Persons With Affective Disorder
The purpose of this study is to test the efficacy of remedial cognitive intervention using The Functional Brain Trainer VR (FBT, Intendo ©) to improve cognitive functioning, participation in daily life occupations, and functional…
- Trial name
- NCT04288609
- Testing
- Intendu, Paper and Pencil cognitive remediation training
- Volunteers
- 40 people
- Sponsor
- Geha Mental Health Center
Depressive Disorder, Major
Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety and tolerability of vortioxetine, once daily (QD), compared with placebo in adults with major depressive disorder.
- Trial name
- NCT01153009
- Testing
- Vortioxetine, Duloxetine
- Where
- 56 sites in United States
- Volunteers
- 614 people
- Sponsor
- Takeda
Bereavement
Long-term Consequences of Bereavement in Children, Adolescents and Young Adults
The purpose of this study is to examine how the death of a parent as a child, adolescent or young adult affects health and psychosocial wellbeing in adult life and to evaluate the impact in adult life of counseling to children…
- Trial name
- NCT01453699
- Where
- Denmark
- Volunteers
- 1,225,660 people, healthy volunteers welcome
- Sponsor
- Danish Cancer Society
Major Depressive Disorder
Prevalence of Major Depression Among Immigrants in Santiago, Chile
The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile. The hypotheses are: 1.
- Trial name
- STRING (NCT04114565)
- Where
- Chile
- Volunteers
- 1,092 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
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