Clinical trials: Affective Disorder
Major Depressive Disorder
A Study Comparing Duloxetine and Placebo in Assessing Energy and Vitality in Major Depressive Disorder (MDD) Patients
Study F1J-US-HMFS comprises two identical multicenter, 9-month, randomized, placebo-controlled, double-blind, trials (HMFSa and HMFSb).
- Trial name
- NCT00536471
- Testing
- Duloxetine hydrochloride
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 776 people
- Sponsor
- Eli Lilly and Company
Treatment Resistant Depression
Low Field Magnetic Stimulation for Treatment Resistant Depression
This is a double-blind, randomized, sham-controlled phase II study of the effects of Low Field Magnetic Stimulation (LFMS) on brain circuitry of adults with treatment-resistant Major Depressive Disorder (MDD).
- Trial name
- NCT01944644
- Testing
- Active Low Field Magnetic Stimulation
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Weill Medical College of Cornell University
Premenstrual Dysphoric Disorder
Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder
This study will evaluate the effectiveness of sertraline in reducing symptoms in women diagnosed with premenstrual dysphoric disorder.
- Trial name
- NCT00536198
- Testing
- Sertraline
- Where
- 3 sites in United States
- Volunteers
- 252 people
- Sponsor
- Yale University
Bipolar Disorder
Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT)
Despite currently available treatment, a large proportion of patients with bipolar disorder (BD) suffer from affective symptoms, impaired psychosocial and cognitive function.
- Trial name
- NCT05035316
- Testing
- acetylsalicylic acid, Calcium
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Lars Vedel Kessing
Schizo-affective Disorder, Bipolar Disorder
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders
The purpose of this study is to assess the efficacy of oral glycine as an augmentation strategy in two psychotic patients with a triplication (4 copies) of the gene glycine decarboxylase (GLDC).
- Trial name
- NCT01720316
- Testing
- Glycine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mclean Hospital
Schizophrenia, Psychotic Disorders
Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: 3-years Follow-up
Cognitive enhancement is a primary goal in treating individuals with schizophrenia. Cognitive deficits are already present at the first break of the illness, seem to remain stable during early phases and noticeably influence…
- Conditions
- Schizophrenia, Psychotic Disorders, Psychosis
- Trial name
- PAFIP3_nc3Y (NCT03883204)
- Testing
- Aripiprazole, Risperidone
- Where
- Spain
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Depression, Anxiety
Brief, High-dose rTMS for Depression
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination.
- Trial name
- NCT04657432
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Anxiety Disorders, Psychological Distress
Feasibility and Acceptability of Problem Management Plus (PM+) for Prisoners in the Netherlands - a Pilot RCT
The goal of this pilot randomised controlled trial is to evaluate the feasibility and acceptability of the - specifically to the prison context adapted - World Health Organization's Problem Management Plus (PM+) intervention for…
- Conditions
- Anxiety Disorders, Psychological Distress, Depressive Disorder
- Trial name
- PROSPER (NCT05927987)
- Testing
- Problem Management Plus (PM+)
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- VU University of Amsterdam
Major Depressive Disorder (MDD)
Light, Ion, and Fluoxetine Efficacy (LIFE) in Depression
This study will investigate the additional benefits of light and ion therapy as added treatments to an antidepressant (fluoxetine) in subjects with major depressive disorder (MDD), versus treatment with fluoxetine alone.
- Trial name
- NCT00958204
- Testing
- Light treatment, Negative ion therapy, Fluoxetine
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- University of British Columbia
Major Depressive Disorder
A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression
The purpose of this study is to assess the efficacy of esketamine compared with placebo in improving symptoms of depression in patients with treatment resistant depression.
- Trial name
- NCT01640080
- Testing
- Esketamine
- Where
- 9 sites in Belgium, Germany and 1 more
- Volunteers
- 30 people
- Sponsor
- Janssen Research & Development, LLC
Depression, Postpartum
Effect of Peripartum 40 Hz Audiovisual Stimulation on Postpartum Depression in Women Undergoing Elective Cesarean Section: A Randomized Clinical Trial
Postpartum depression (PPD) is a common mental health condition affecting 10%-30% of new mothers, with serious consequences for both mother and child.
- Trial name
- NCT07807462
- Testing
- 40 Hz Audiovisual Stimulation
- Where
- China
- Volunteers
- 204 people
- Sponsor
- The First People's Hospital of Lianyungang
Bipolar Disorder (BD), Bipolar Disorder I or II
FOCUS Bipolar: Families Opening Conversations for Understanding Signs
Bipolar disorder often runs in families, but early symptoms in youth can go unrecognized for years. This project evaluates a structured, family-centered approach to informed screening for youth ages 7-21 who have a biological…
- Conditions
- Bipolar Disorder (BD), Bipolar Disorder I or II, Bipolar Disorder Family Members, Screening Tool
- Trial name
- FOCUS Bipolar (NCT07622927)
- Testing
- Co-design Workshop (Observational Procedure), Alpha Testing (Observational Procedure), Beta Testing (Observational Procedure)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder
Behavioral Activation for Major Depression With and Without Mindfulness
The objective of the study is to compare, in individuals who meet the diagnostic criteria for major depression, the effects of Behavioral Activation (BA) strictly behavioral with a BA protocol that includes mindfulness practices.
- Trial name
- NCT04768361
- Testing
- Behavioral Activation without Mindfulness, Behavioral Activation with Mindfulness
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Miguel Servet
Major Depressive Disorder, Surgery
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery.
- Conditions
- Major Depressive Disorder, Surgery, Orthopedic Disorder
- Trial name
- NCT03861988
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Major Depression, Fibromyalgia
A Pilot Study of TMS Effects on Pain and Depression in Patients With Fibromyalgia
In this pilot study, the PI proposes to include 20 African American participants with Fibromyalgia to explore the effect of r TMS on pain and depressive symptoms.
- Trial name
- TMS (NCT00523302)
- Testing
- Active TMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Major Depression
Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
In this pilot study, investigators aim to combine D-cycloserine, lurasidone, and single-day repeated intermittent Theta Burst Stimulation (iTBS) to preliminarily assess clinical improvement in an open-label cohort and monitor for…
- Trial name
- SPARC-LI (NCT07785102)
- Testing
- TMS, NRX-101
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mclean Hospital
Bipolar Disorder
GSK Drug Single Dose Escalation And Their Effect On Resting Motor Threshold In Healthy Volunteers
This is a First Time in Human Study to assess the safety, tolerability, pharmacokinetics and resting motor threshold (rMT) of single doses of GSK drug in healthy volunteers.This will be a 2 part and 2 centre study.Part 1 will be…
- Trial name
- NCT00488566
- Testing
- GSK drug, Lamictal
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Biogen
Major Depressive Disorder, Healthy Participants
A Study of the Neurobiology of Depression
Previous research studies have shown that depression is associated with changes in structure and activity in different parts of the brain and that antidepressant medication can affect brain activity in different parts of the…
- Trial name
- NCT01051466
- Testing
- Duloxetine
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Bipolar Depression
Safety and Efficacy of RGH-188 (Cariprazine) in Bipolar Depression
The purpose of this study is to evaluate the efficacy, safety, and tolerability of cariprazine in the treatment of outpatients with bipolar depression.
- Trial name
- NCT00852202
- Testing
- cariprazine
- Where
- 26 sites in United States
- Volunteers
- 234 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder
Fluoxetine vs. Brief Psychotherapy for Major Depression
In this study we compare two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before…
- Trial name
- NCT00714779
- Testing
- Fluoxetine, Short-term psychodynamic psychotherapy
- Volunteers
- 85 people
- Sponsor
- University of Turku
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