Clinical trials: Affective Disorder
Schizophrenia, Bipolar Disorder
Indicated Prevention of Psychotic Disorders With Low-dose Lithium
This study investigates the neuroprotective properties of low-dose lithium in young individuals at ultra-high risk of developping a first psychotic episode.
- Conditions
- Schizophrenia, Bipolar Disorder, Psychotic Disorders
- Trial name
- NCT00202306
- Testing
- lithium carbonate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Major Depressive Disorder
Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression
Several lines of evidence support the existence of an underlying abnormality in brain energy metabolism may play a key role in the biology of mood disorders.
- Trial name
- NCT01465165
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Paul Carlson
Bipolar Disorder, Depression
Depression, Obesity and Inflammatory Markers
The purpose of this study is to better understand the relationship between bipolar disorder, body weight, and inflammation in the body (N=180).
- Conditions
- Bipolar Disorder, Depression, Obesity
- Trial name
- NCT02765100
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Weill Medical College of Cornell University
Depression
Measuring Quality of Decisions About Treatment of Depression
The purpose of this randomized controlled trial is to examine the impact of a patient decision aid on the quality of decisions about managing symptoms of depression.
- Trial name
- NCT01152307
- Testing
- DVD/Booklet: Coping with Symptoms of Depression
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- University of Massachusetts, Boston
Borderline Personality Disorder
Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder
The effects of a psychological treatment, Mentalization-Based Treatment, was studied using a research protocol with patients with mood swings and impulsive behavior (borderline personality disorder).
- Trial name
- NCT03295838
- Testing
- Mentalization-based treatment
- Volunteers
- 75 people
- Sponsor
- Karolinska Institutet
Depression, Involutional, Major Depresssion
Rapid Antidepressant Effects of Yohimbine in Major Depression
This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours.
- Trial name
- NCT00078715
- Testing
- Yohimbine hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety
Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGen
People have had to make a lot of changes to their lives due to the COVID-19 health crisis. Most experts agree that social distancing and other safety measures have taken a toll on people s mental health.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT04684615
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Post Partum Depression
Effectiveness of Thinking Healthy Program for Prevention of Antenatal Depression
The trial is to evaluate the effect of an evidence-informed, depression focused early prenatal prevention intervention at six weeks' postpartum.
- Trial name
- PAD (NCT04663243)
- Testing
- Thinking healthy Program sessions designed for antenatal period
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Bipolar Disorder (BD), Bipolar Disorder NOS
Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents
The present study is an open trial of ketogenic diets for adolescents and young adults (ages 12-21 yrs) in the depressive or mixed phases of bipolar disorder (BD).
- Conditions
- Bipolar Disorder (BD), Bipolar Disorder NOS, Bipolar Disorder I or II, Bipolar Spectrum Disorder
- Trial name
- CBN Keto (NCT06920940)
- Testing
- Ketogenic Therapy
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Depression
Life Improvement Following Traumatic Brain Injury
The purpose of this study is to test the effectiveness of a telephone-based and in-person Cognitive Behavioral Therapy (CBT) intervention for treating Major Depressive Disorder (MDD) following Traumatic Brain Injury.
- Trial name
- LIFT (NCT00878150)
- Testing
- In-person Cognitive Behavioral Therapy, Telephone Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Bipolar Disorder, Dyssomnias
Sleep Disturbance and Bipolar Disorder
The study aims to evaluate a psychological intervention for individuals who suffer from sleep disturbance and bipolar disorder. We are hoping that this treatment will: (1) improve the quality of life of individuals with bipolar…
- Trial name
- NCT00993850
- Testing
- Cognitive behavioral therapy for insomnia, Bipolar education
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Berkeley
Schizophrenia, Schizoaffective Disorder
Virtual Reality Job Interview Training in Severe Mental Illness
This is a randomized controlled trial to evaluate the community-based effectiveness of virtual reality job interview training (VR-JIT). Northwestern University is partnering with Thresholds Inc.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depressive Disorder
- Trial name
- NCT03049813
- Testing
- Virtual Reality Job Interview Training, Supported Employment (Services as Usual)
- Where
- 4 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Michigan
Psychoses, Affective Disorder
Patient-controlled Admissions in Inpatient Mental Health Services
Patient-controlled admissions are short self-referred inpatient admissions in mental health services without approval by clinicians. The intention is to reduce a high use of inpatient care.
- Trial name
- NCT03609515
- Testing
- Patient-controlled admission
- Volunteers
- 58 people
- Sponsor
- University Hospital, Akershus
Major Depressive Disorder (MDD)
Comparison of Yuxintine With Placebo in Treatment of MDD
The purpose of this study is to determine whether Yuxintine Capsule in different doses are effective in the treatment of Depression.
- Trial name
- NCT02395263
- Testing
- Yuxintine
- Where
- 10 sites in China
- Volunteers
- 160 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Schizoaffective Disorder
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia
This study will evaluate the effectiveness of valbenazine on patient- and clinician-reported outcomes assessing health-related quality of life, functioning, and treatment effect in participants with tardive dyskinesia (TD) who…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT05859698
- Testing
- Valbenazine
- Where
- 18 sites in United States
- Volunteers
- 59 people
- Sponsor
- Neurocrine Biosciences
Schizophrenia, Major Depressive Disorder
DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole
This is a 12 month, pragmatic trial designed to assess the differences in a digital medicine system (DMS)- ABILIFY MYCITE (Aripiprazole tablets with sensor)- measuring adherence versus treatment as usual (TAU) for adult patients…
- Conditions
- Schizophrenia, Major Depressive Disorder, Bi-Polar Disorder, Schizo Affective Disorder
- Trial name
- DIMES (NCT03881449)
- Testing
- ABILIFY MYCITE
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Durham VA Medical Center
Bipolar Disorder
White Matter in Pediatric Bipolar Disorder: A DTI Study
Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL.
- Trial name
- NCT00391235
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Mood Disorders, Suicide
Investigation on Suicide Risk Factors of Patients With Mood Disorders
This study investigates the level and distribution of suicide risk and learned suicide ability of patients with mood disorders, investigates the related risk factors of suicide and suicide ability formation of patients with mood…
- Trial name
- NCT07523490
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tianjin Anding Hospital
Depressive Disorder, Major
Effectiveness of Cariprazine Monotherapy for Treatment of Major Depressive Disorder
This trial protocol aims to evaluate the effectiveness and safety of cariprazine monotherapy compared to treatment as usual for major depressive disorder (MDD) in a pragmatic open-label randomized controlled trial (RCT) conducted…
- Trial name
- NCT05933538
- Testing
- Cariprazine, Treatment as usual
- Volunteers
- 110 people
- Sponsor
- Sultan Qaboos University
Depressive Disorder, Major, Metabolic Syndrome X
Pioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrome
The goal of this study is to begin to test whether or not pioglitazone, an FDA approved medication used to treat high blood sugar, may be safe and effective in treating Major Depressive Disorder (MDD) in patients with comorbid…
- Trial name
- NCT00671515
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Joseph Calabrese, MD
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