Clinical trials: Affective Disorders
Violence, Domestic, Stress Related Disorder
Applied Social Neuroscience: the Building Resilience Among Women Project
Intimate partner violence (IPV) is the most common and alarming form of violence against women, affecting up to 25% of all women in Catalonia.
- Conditions
- Violence, Domestic, Stress Related Disorder, Depressive Disorder
- Trial name
- BRAW (NCT03623555)
- Testing
- Trier Social Stress Test, Salivary cortisol
- Where
- Spain
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Ximena Goldberg
Major Depressive Disorder
Switching From SSRI to Desvenlafaxine on Cognitive Functioning
Given the importance of cognitive function on depressed patients' treatment outcome and return to premorbid functioning, the effect of antidepressant drugs on cognition has become of primary concern.
- Trial name
- NCT03432221
- Testing
- Desvenlafaxine
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Major Depressive Disorder
A Study of LY2216684 and Theophylline in Healthy Subjects
The primary objective of this study is to confirm that LY2216684 is not an inhibitor of cytochrome P450 1A2 (CYP1A2) in healthy participants using theophylline as a probe substrate for the enzyme.
- Trial name
- NCT01263106
- Testing
- LY2216684, Theophylline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depression, Alzheimer's Disease
Retinoic Acid Homeostasis in Neuropsychiatric Diseases
It is hypothesized, that local retinoic acid (RA) homeostasis is functionally involved in the pathophysiology of depression. In a cross-sectional (and partly longitudinal) analysis, serum RA status will be assessed in healthy…
- Conditions
- Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia
- Trial name
- RAHND (NCT02439099)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study
This longitudinal cohort study aims to detect the topographical nature of the white matter microstructure and resting state functional connectivity patterns across the whole brain in the evolution of pathology as a function of…
- Conditions
- Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Affective and Somatic Complaints, Cognitive Impairments
- Trial name
- NCT02868684
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Major Depression
Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene
The study evaluates the ABCB1-genotype dependent efficacy of a quick dose-escalation strategy within 28 days of treatment with approved antidepressants that are known substrates of the P-glycoprotein, an efflux pump of the…
- Trial name
- NCT02237937
- Testing
- Paroxetine, Sertraline, Citalopram
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HolsboerMaschmeyer NeuroChemie GmbH
Bipolar Disorder, Pregnancy
Antimanic Drug Use in Pregnancy
The purpose of this study is to learn about the effects of bipolar disorder or the use of antimanic medications on the mother's health and wellbeing during pregnancy and for the first postpartum year.
- Trial name
- AMUP (NCT00585702)
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depressive Disorder, Depression, Unipolar
A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression
Antidepressants is the primary treatment for depression, but only less than 50% of the patients get clinical remission. There is no objective markers to select antidepressants for clinical treatment .
- Trial name
- NCT03623711
- Testing
- Escitalopram, Duloxetine, Bupropion
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yuqi Cheng
Schizophrenia, Depressive Disorder, Major
Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and Depression
The investigators will acquire simultaneous EEG and fMRI data from Veterans with depression and schizophrenia and mentally healthy Veterans to assess early sensory responses, context updating, and responses to emotional images.
- Trial name
- NCT03758495
- Testing
- Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
Major Depressive Disorder
The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive Disorder
Major depressive disorder (MDD) is highly prevalent, affecting nearly 4% of the global population. Pharmacotherapy is the frontline treatment recommended by the guideline, but it also has some limitations such as delayed onset…
- Trial name
- NCT05720637
- Testing
- SSRI, SIA, AIA
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xiaomei Shao
Bipolar Affective Disorder
Bipolar Research Study Using MR Imaging
In this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia.
- Trial name
- NCT02083978
- Testing
- MRI scanning
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Washington University Early Recognition Center
Depression, Depressive Disorder
Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school)
The aim of this study is to investigate the naturalistic user experience and acceptance of the German website "ich bin alles @Schule".
- Conditions
- Depression, Depressive Disorder, Depression in Children, Depression in Adolescence
- Trial name
- NCT06668688
- Testing
- "ich bin alles @Schule" (i am everything @school; www.schule.ich-bin-alles.de)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Bipolar Disorder
A Genetic Family Cohort Study of Bipolar Disorder in Chinese Han Population
This study intends to find out the pathogenic genes of bipolar disorder by collecting the two-phase family of Chinese Han population with the large sample using a family cohort study design, combined with the new generation of…
- Trial name
- NCT04024553
- Where
- China
- Volunteers
- 2,520 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Neural Response to Inflammatory Challenge in Major Depressive Disorder
This is a parallel group, double-blinded, placebo-controlled study. Participants with MDD (n=90) and HC (n=90) will be randomly assigned (2:1) to receive either lipopolysaccharide (LPS) (0.8ng/kg of body weight) or placebo (same…
- Trial name
- NCT04751331
- Testing
- LPS, Saline
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Depression, Mood Disorders
Functional MRI Before and After Treatment for Depression
The purpose of this study is to help us understand how depression changes brain activity and how this relates to mood, anxiety, and cognitive functions like memory.
- Conditions
- Depression, Mood Disorders, Depressive Disorder
- Trial name
- NCT00896441
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Stanford University
Severe Acute Malnutrition, Cognitive Impairment
Intervening to Repair Cognitive and Behavioural Problems in Adults Exposed to Childhood Malnutrition
Globally, in 2011, 52 million children under 5 years old suffered from acute malnutrition, and a further 165 million children showed evidence of chronic undernutrition or stunting.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Emotional Disturbances
- Trial name
- NCT04053218
- Testing
- Exercise plus omega-3 supplement
- Where
- Jamaica
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Post-traumatic Stress Disorder, Depressive Disorder
Project SERVE: Post Deployment Functioning
Functional recovery is of the utmost importance to evaluate in our returning Operation Enduring and Iraqi Freedom Veterans so that we can better understand their needs and experiences during the readjustment process from warzone…
- Conditions
- Post-traumatic Stress Disorder, Depressive Disorder, Alcoholism
- Trial name
- NCT01123642
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, Depressive Disorder, Major
Depression and Immune Function in Multiple Sclerosis (MS)
Depression is one of the most common symptoms of multiple sclerosis (MS) with a life-time prevalence of major depressive disorder (MDD) of up to 50%.
- Trial name
- DENIM (NCT02740296)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Depression, Depressive Disorder
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information.
- Conditions
- Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT06080646
- Testing
- cross-sectional MRI and EEG assessments (NO INTERVENTION)
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center