Clinical trials: Africa
Undiagnosed HIV Infection, Populations That Are Reluctant to Test for HIV
Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention to Locate Undiagnosed Cases and Reduce HIV-related Stigma
In South Africa's large generalized HIV epidemic, male-to-female transmission comprises a large proportion of transmission events, but men are much less likely to seek HIV testing, and disproportionately remain undiagnosed.
- Conditions
- Undiagnosed HIV Infection, Populations That Are Reluctant to Test for HIV, Long-term Undiagnosed HIV Infection, Individuals With Newly-diagnosed HIV Infection
- Trial name
- E-SNRHT (NCT06857071)
- Testing
- Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention
- Where
- South Africa
- Volunteers
- 2,480 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
HIV-1-infection
Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa
This is a prospective observational cohort study enrolling participants in South Africa and Uganda who are prescribed an HIV treatment regimen containing lamivudine, tenofovir, and dolutegravir, which is known as TLD.
- Trial name
- DISCO (NCT04066036)
- Testing
- This is an observational study only.
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 999 people
- Sponsor
- Massachusetts General Hospital
HIV-1-infection
ANRS 12372 MODERATO Study
MODERATO is a phase III, open-label, randomized, multicenter, non-inferiority trial conducted in West and Central Africa (Cameroon, Côte d'Ivoire, Burkina Faso).
- Trial name
- MODERATO (NCT04022967)
- Testing
- dolutegravir, atazanavir boosted with ritonavir, tenofovir + lamivudine +efavirenz or dolutegravir + lamivudine + tenofovir
- Where
- 5 sites in Burkina Faso, Cameroon and 1 more
- Volunteers
- 480 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Abortion, Induced
Comparison of the Safety of First Trimester Abortions Performed by Physicians and Non-Physicians in South Africa and Viet Nam.
There have been no studies in developing countries assessing the safety of midlevel providers (MLP) compared to physicians in performing first-trimester manual vacuum aspiration abortion.
- Trial name
- NCT00370487
- Volunteers
- 2,860 people, healthy volunteers welcome
- Sponsor
- World Health Organization
HIV
Activating Treatment as Prevention Through Community Mobilization in South Africa
The purpose of this study is to evaluate the impact of a community mobilization intervention on the uptake of HIV testing, linkage to and retention in HIV care using a community, cluster randomized trial.
- Trial name
- NCT02197793
- Testing
- Community Mobilization Program
- Where
- South Africa
- Volunteers
- 2,338 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
This cohort study plans to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth, Pregnancy; Infection, Microbial Colonization
- Trial name
- NCT06131749
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 603 people
- Sponsor
- University of Bern
HIV-1-infection
A Study to Test Three Experimental HIV Vaccines in Healthy Adults.
HIV-CORE 006 is a Phase 1 double-blind placebo-controlled trial, in which the mosaic immunogens are delivered by a prime-boost regimen of non-replicating simian adenovirus followed by non-replicating poxvirus MVA.
- Trial name
- HIV-CORE 006 (NCT04553016)
- Testing
- Vaccine
- Where
- 4 sites in Kenya, Uganda and 1 more
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Development, Child, Behavior, Social
Bahir Dar Child Development Study, Ethiopia
The goal of this observational study is to learn about typical neurodevelopment in children aged 6 months to 5 years who live in Bahir Dar, Ethiopia.
- Trial name
- BCD (NCT06648863)
- Where
- Ethiopia
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Growth and Development
Infant Peri-Exposure Prophylaxis to Prevent HIV-1 Transmission by Breastfeeding: Mechanisms & Safety
General objective To assess the long-term safety and efficacy of one-year infant prophylaxis using lamivudine (3TC) or lopinavir/ritonavir (LPV/r) to prevent post-natal transmission through breastfeeding.
- Trial name
- NCT03519503
- Where
- 4 sites in Burkina Faso, South Africa and 2 more
- Volunteers
- 562 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in Africa
The goal of the CHAPAS-5 clinical trial is to find out how well different HIV treatments work in children and young people (from 4 weeks up to under 15 years old) living with HIV, including those starting treatment for the first…
- Trial name
- CHAPAS-5 (NCT07792096)
- Testing
- Dolutegravir (DTG), Abacavir (ABC), Lamivudine (3TC)
- Volunteers
- 800 people
- Sponsor
- University College, London
Surgical Site Infection
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting.
- Trial name
- SSI2 (NCT00801099)
- Testing
- Amoxicillin/Clavulanic Acid
- Where
- Switzerland
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria
Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa
This study is designed to characterise P. falciparum transmission intensity in subjects aged ≥6 months and <10 years by measurement of P.
- Trial name
- NCT01954264
- Testing
- Capillary blood sample, Data collection
- Where
- 3 sites in Burkina Faso, Senegal
- Volunteers
- 2,421 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Reproductive Health, Herpesvirus Infection
Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout
A 4-armed cluster randomised controlled trial conducted among secondary schoolgirls in Siaya, western Kenya, where clusters are the unit of allocation and schoolgirls the unit of measurement.
- Conditions
- Reproductive Health, Herpesvirus Infection, HIV Infections, Woman Abuse
- Trial name
- CCg (NCT03051789)
- Testing
- Menstrual Cup, Cash transfer, Cups and Cash
- Where
- Kenya
- Volunteers
- 4,138 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
HIV/AIDS, Tuberculosis
Targeted Universal TB Testing With Simultaneous TPT Prescribing Among People Living With HIV in South Africa
Background: In 2023, the South African Department of Health introduced targeted universal TB testing (TUTT) at antiretroviral therapy (ART) initiation (irrespective of the presence of TB symptoms).
- Trial name
- TUTT-PT (NCT06739915)
- Testing
- TUTT-PT Intervention
- Where
- South Africa
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV, Contraception
The Quatro Study: Acceptability Study of (Placebo) Vaginal Delivery Forms for Preventing HIV and Unintended Pregnancy
The purpose of The Quatro Study is to assess the acceptability, preferences, user experience and effect on sexual behavior of four different vaginal microbicide or multi-purpose technology (MPT) delivery forms, using placebo…
- Trial name
- NCT02602366
- Where
- 2 sites in South Africa, Zimbabwe
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- CONRAD
HIV Infections, Tuberculosis
Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in South Africa
The overall aim of the project is to evaluate rifabutin (RBT) as a replacement for rifampicin (RMP), for the combined treatment of tuberculosis and HIV infection.
- Trial name
- NCT00640887
- Testing
- rifabutin in combination with efavirenz, rifabutin in combination with nevirapine, rifabutin in combination with lopinavir/ritonavir
- Where
- South Africa
- Volunteers
- 48 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Obesity, Diabetes Mellitus, Type 2
This Study Assessed the Impact of Diet on Gastric Emptying Time and Metabolic Flexibility
Consumption of slowly digestible carbohydrates can elicit higher satiety feeling compared to rapidly digestible carbohydrates, however not all individuals respond the same.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
- Trial name
- IODC (NCT03630263)
- Testing
- Raw Corn Starch, No Raw Corn Starch
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Purdue University
Non-Communicable Disease
Developing Non-Communicable Disease Registries in Africa : A Step Towards Providing Quality Data for Improving Patient Outcomes
This umbrella protocol seeks to develop robust data registries for non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) with the aim of providing accurate and comprehensive data for the evaluation of such diseases in…
- Trial name
- NCT03473795
- Testing
- Questionnaire forms, Bio-specimen samples
- Where
- 14 sites in United States, Nigeria
- Volunteers
- 6,990 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Epilepsy
Risk Factors and Etiologies of Epilepsy in Urban and Rural Rwanda
Epilepsy is one of the most common chronic brain disorders. Up to 85% of persons living with epilepsy (PwE) live in the developing world. In sub-Saharan Africa (SSA), Rwanda has one of the highest prevalence rates (±5%).
- Trial name
- REpiCa (NCT05698537)
- Testing
- EEG, Neuroimaging, Blood sample
- Where
- Rwanda
- Volunteers
- 1,745 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
HIV
Standing Tall (Yima Nkqo)
The investigators propose the Standing Tall study, a prospective randomised study of strategy to optimize community-based ART initiation in South Africa.
- Trial name
- NCT04568460
- Testing
- Intervention Group Sessions
- Where
- 3 sites in United States, South Africa
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital