Clinical trials: Africa
Child Abuse, Child Maltreatment
Child Protective Outcomes Among Ultra-poor Families in Burkina Faso
This study tests the effects of family-based economic empowerment intervention, alone and in combination with child rights sensitization component, on child protective outcomes among ultra-poor families in Nord Region, Burkina…
- Trial name
- NCT02415933
- Testing
- Trickle Up, Trickle Up Plus
- Where
- Burkina Faso
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV
Implementation Effectiveness and Safety of Tenofovir Gel Provision Through Family Planning Services
The purpose of this study is to assess the effectiveness of an implementation model which integrates tenofovir gel provision into existing family planning services.
- Trial name
- NCT01691768
- Testing
- 1% tenofovir gel
- Where
- 2 sites in South Africa
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
AIDS, Stress
Socioenvironmental Determinants of Psychological Functioning, Mental Health and AIDS in Mali
This project is a collaboration between the Centre Regional de Medecine Traditionnelle (CRMT) of the Malian National Institute of Public Health Research (INRSP) and the Section on Socioenvironmental Studies (SSES).
- Trial name
- NCT00339391
- Where
- Mali
- Volunteers
- 1,002 people
- Sponsor
- National Institute of Mental Health (NIMH)
HIV, Trauma Exposure
A Randomized Trial of ImpACT+, a Coping Intervention for HIV Infected Women With Sexual Trauma in South Africa
ImpACT+ (Improving AIDS Care after Trauma+), is an individual-level coping intervention to address traumatic stress and HIV care engagement among South African women with sexual trauma histories.
- Trial name
- ImpACT+ (NCT04793217)
- Testing
- Improving AIDS Care After Trauma +, Adapted Problem-Solving Therapy
- Where
- South Africa
- Volunteers
- 350 people
- Sponsor
- Columbia University
Drug Resistant Malaria Due to Plasmodium Falciparum
Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa
The antimalarial drugs efficacy and safety study will be conducted in the Clinics and hospital of the Cameroon Development Corporation (CDC) Estates, Tiko Health District, located in a typical forest and rainfall area in the…
- Trial name
- NCT02974348
- Testing
- Arthemeter-lumefantrine, Artesunate mefloquine, Dihydroartemisinin piperaquine
- Where
- Cameroon
- Volunteers
- 300 people
- Sponsor
- University of Bamenda
HIV-1 and HSV-2 Coinfection, HIV Infections
Usage of Acyclovir for Suppression of HIV-1 and HSV-2 Coinfected Persons in Cameroon
The study proposed that both clinical and subclinical HSV reactivation is associated with increased HIV shedding from mucosal surfaces, which may increase the infectiousness of HIV-1/HSV-2 coinfected persons.
- Trial name
- NCT00209313
- Testing
- Acyclovir
- Where
- Cameroon
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center
Streptococcus Agalactiae (Streptococcus Group B)
The Clinical and Molecular Epidemiology of Streptococcus Agalactiae Colonisation on the Kenyan Coast
Sub-Saharan Africa (sSA) has the highest regional rates of perinatal mortality worldwide. Group B Streptococcus (GBS) has been identified as a leading cause of early onset neonatal sepsis (EOS, in <7 days of life) in sSA.
- Trial name
- GBS (NCT01757041)
- Where
- 4 sites in Kenya
- Volunteers
- 7,967 people
- Sponsor
- University of Oxford
Lead Exposure, High Blood Lead Level
Lead Exposure Intervention Program
The goal of this clinical trial is to learn if BLL (blood lead level) screening and "healthy home" lead prevention program created in the US is adaptable to a Sub-Saharan African context.
- Trial name
- LEIP (NCT07401251)
- Testing
- Home visit with tailored messages, In-clinic lead risk reduction intervention
- Where
- Kenya
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV, Sexual Risk
WHC+ (Women's Health CoOp PLUS)
This study compares the effects of standard HIV test, treat and retain (TTR) practices with TTR plus a woman-focused enhanced strategy--Women's Health CoOp (WHC+) intervention) targeting hard-to-reach and vulnerable alcohol and…
- Conditions
- HIV, Sexual Risk, Sexually Transmitted Diseases, Substance Abuse
- Trial name
- NCT01497405
- Testing
- Test, Treat, Retain(TTR) + Women's Health CoOp (WHC), Test, Treat, Retain(TTR) only
- Where
- 2 sites in United States, South Africa
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- RTI International
Hypertension, HIV
iHEART-SA Intervention Study
Using qualitative data during the formative phase the IHEART-SA research study filled deficiencies in knowledge regarding: 1) what barriers exist to integrating hypertension care within the HIV care setting in South Africa and…
- Trial name
- iHEART-SA (NCT05846503)
- Testing
- 1. Quality and info management system
- Where
- South Africa
- Volunteers
- 4,378 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Sexually Transmitted Infection, Hiv
A Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women: IMARA SA
Programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa are essential to meet global HIV targets.
- Trial name
- IMARA-SA pilot (NCT05504954)
- Testing
- IMARA-SA (intervention group), Health promotion control group
- Where
- South Africa
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Psychological Well-Being
Impact of Preventive Mental Health Programme on Social/Emotional Functioning and Resilience in Children in South Africa
The goal of this clinical trial is to test the effectiveness of a mental health prevention and promotion programme delivered to children (ages 8 to 13) living in under-resourced communities in South Africa.
- Trial name
- NCT06445777
- Testing
- Mental Health Prevention and Promotion
- Where
- South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Little Lions Child Coaching
Streptococcal Infections
Safety and Immunogenicity of a Group B Streptococcus Vaccine in Non Pregnant and Pregnant Women 18-40 Years of Age
This study will evaluate the safety and immunogenicity of a Group B Streptococcus vaccine at one dose in healthy non pregnant women and then in three different doses in healthy pregnant women.
- Trial name
- NCT01193920
- Testing
- Group B Streptococcus Trivalent Vaccine - 20/20/20 μg, Saline solution, Group B Streptococcus Trivalent Vaccine - 0.5/0.5/0.5 μg
- Where
- South Africa
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Hiv
Engaging Men Through HIV Self-Testing With Differentiated Care to Improve ART Initiation and Viral Suppression Among Men in Malawi
Men in sub-Saharan Africa who test HIV-positive continue to have poor ART initiation and retention outcomes. The proposed project will test a home-based ART intervention for men who are living with HIV compared to facility-based…
- Trial name
- NCT04858243
- Testing
- Home-Based ART, Facility-Based ART
- Where
- Malawi
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anemia, Iron Deficiency Anemia
Improving Iron Status of Children: Potential of Amaranth
Introduction: Iron deficiency anaemia remains a significant public health challenge. Localized food based approaches may offer a large opportunity to improve lives and address the widespread micronutrient deficiencies such as…
- Trial name
- NCT01224535
- Testing
- Maize and Amaranth
- Where
- Kenya
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Wageningen University
ART Adherence
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING PUMA)
Antiretroviral therapy (ART) has significantly decreased the morbidity and mortality of HIV infection. However, adherence challenges in taking daily oral ART persist.
- Trial name
- ROVING-PUMA (NCT06423612)
- Testing
- POC urine assay informed enhanced ART adherence counselling for viral suppression
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking Cessation, HIV
Evaluating Smoking Cessation Interventions for PWH in South Africa
The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.
- Conditions
- Smoking Cessation, HIV, Comorbidities and Coexisting Conditions
- Trial name
- Tlogela (NCT05413122)
- Testing
- Varenicline, Nicotine patch, Nicotine gum
- Where
- South Africa
- Volunteers
- 660 people
- Sponsor
- Johns Hopkins University
HIV
Gathering Records to Evaluate Antiretroviral Treatment-Malawi ( GREAT )
To achieve global goals for the treatment of HIV, most high-prevalence countries are experimenting with and scaling up differentiated service delivery models (DSD).
- Trial name
- GREAT (NCT04158895)
- Testing
- Routine medical record data collection
- Where
- Malawi
- Volunteers
- 1,000,000 people
- Sponsor
- Boston University
HIV, Human Immunodeficiency Virus
Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study
The overall goal is to determine whether an end-to-end decentralized delivery service for PrEP is more effective, safe, acceptable, and cost-effective than facility-based PrEP delivery.
- Conditions
- HIV, Human Immunodeficiency Virus, ART
- Trial name
- NCT06176859
- Testing
- HIV PrEP Delivery
- Where
- South Africa
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
COVID-19, SARS CoV 2 Infection
STREngthening COronavirus Disease 2019 (COVID-19) Surveillance in Africa
The aim of this observational study was to develop, with the intended users, an epidemic surveillance and response system that will be effective, sensitive, coordinated and appropriate.
- Conditions
- COVID-19, SARS CoV 2 Infection, COVID-19 Pandemic
- Trial name
- STREESCO (NCT06170320)
- Where
- Benin
- Volunteers
- 7,000 people
- Sponsor
- Institut de Recherche pour le Developpement