Clinical trials: African Americans
Kidney Transplant
Reducing Disparities in Living Donor Transplant Among African Americans
For most of the patients in the United States with end stage renal disease (ESRD), kidney transplantation represents the optimal treatment, and living donor kidney transplantation (LDKT) is preferable.
- Trial name
- NCT03819686
- Testing
- Living ACTS website, Standard transplant education procedures
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- Emory University
Smoking, Smoking Cessation
Message Testing in Aging African American Smokers
The goal of this study is to examine different messages to motivate smokers who self-identify as an African American current smoker, between the ages of 50-80 years old to quit smoking.
- Trial name
- MCAAAS-2 (NCT05819086)
- Testing
- Rate Emotional Response, Rate Impact of Message
- Where
- United States
- Volunteers
- 839 people
- Sponsor
- University of Wisconsin, Madison
Vitamin D Deficiency
Personalized Vitamin D Supplementation in European and African Americans
The proposed study is a randomized, double-blind, controlled, multi-center clinical trial of six months of daily oral vitamin D3 (cholecalciferol).
- Trial name
- NCT02362269
- Testing
- Vitamin D
- Where
- 2 sites in United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parenting
Randomized Controlled Trial of Prenatal Coparenting Intervention (CoparentRCT)
This R01 tests through RCT methodology efficacy of a new intervention designed specifically to aid development of positive coparenting alliances between at-risk (unmarried, uncoupled, low income) African American mothers and…
- Trial name
- CoparentRCT (NCT03097991)
- Testing
- Focused Coparenting Consultation
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of South Florida
High Blood Pressure
The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
High blood pressure (hypertension) is called the "silent killer" because many people do not know they have it, and do not know when it is well controlled.
- Trial name
- NCT01049009
- Testing
- Nebivolol, Metoprolol XL
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Emory University
Healthy Subjects
THE EFFECT OF CYP3A5 GENOTYPE ON THE PHARMACOKINETICS OF MARAVIROC
This will be an open-label, parallel group, multiple dose study in approximately 48 healthy male or female subjects of African American and Caucasian self-reported race, to assess the effect of CYP3A5 genotype on the PK of MVC…
- Trial name
- NCT02625207
- Testing
- Maraviroc (Part 1), Maraviroc (Part 2), Darunavir/cobicistat (Part 2)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Colorectal Cancer
A Smartphone-Based Intervention to Improve Colorectal Cancer Screening in African American Men
The goal of this clinical trial is to test a new smartphone-based program designed to help African American men get screened for colorectal cancer (CRC).
- Trial name
- NCT06052202
- Testing
- CRC mHealth, Control
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- ISA Associates, Inc.
Alzheimer's Disease
Health Evaluation in African Americans Using RAS Therapy
The purpose of this study is to determine if telmisartan, an FDA approved blood pressure medication, may also have beneficial effects on Alzheimer's disease prevention in African Americans, who are at high risk for Alzheimer's…
- Trial name
- HEART (NCT02471833)
- Testing
- Telmisartan 20mg, Telmisartan 40mg
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University
Hepatitis C
Alisporivir (Deb025) and Boceprevir Triple Therapies in African American Participants Not Previously Treated for Chronic Hepatitis C Genotype 1
This study will assess the safety and efficacy of alisporivir (ALV) and boceprevir (BOC), each in combination with Peginterferon alfa-2a (PEG) and Ribavirin (RBV), in African American participants who have never received…
- Trial name
- NCT01446250
- Testing
- Alisporivir, Boceprevir, Peginterferon alfa-2a
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Debiopharm International SA
Hypertension
Gut Butyrate and Blood Pressure in African Americans
African Americans have the greatest burden of hypertension. Recently, the short-chain fatty acid, butyrate, has been reported to have some effect on blood pressure.
- Trial name
- NCT04415333
- Testing
- Sodium Butyrate 5 mmol, Sodium Butyrate 80 mmol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Blacks and Exacerbations on Long Acting Beta Agonists (LABA) vs. Tiotropium (BELT)
We are doing this study to learn how genes affect the way that people, specifically Black people, respond to treatment for asthma.
- Trial name
- BELT (NCT01290874)
- Testing
- Tiotropium, Salmeterol, Formoterol
- Where
- 13 sites in United States
- Volunteers
- 1,070 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes
Vitamin D Supplementation on Cardiovascular Risk Factors
The purpose of the present pilot study is to determine the effect of vitamin D supplementation (4000 IU or 6000 IU once daily for 6 months) on reducing heart disease risk and in improving blood glucose control in type 2 Diabetes…
- Trial name
- NCT01412710
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Florida International University
Tobacco Use Disorder
Comparative Abuse Liability Among African American and White Smokers
The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn.
- Trial name
- NCT04646668
- Testing
- E-cigarette and Heat not burn
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Drug Dependence
Intensive Outpatient Versus Outpatient Treatment With Buprenorphine Among African Americans
The purpose of this study is to compare the effectiveness of different levels of counseling (intensive outpatient versus standard outpatient) on treatment outcomes for African American adult patients receiving buprenorphine in 2…
- Trial name
- NCT01096550
- Testing
- Outpatient, Intensive Outpatient
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Friends Research Institute, Inc.
Hormone Receptor Positive HER-2 Negative Breast Cancer
Palbociclib / Letrozole or Fulvestrant in African American Women With HR+ HER2- Breast Cancer
This study aims to evaluate the hematological safety of palbociclib with letrozole and fulvestrant in African American women with hormone receptor positive HER2 negative advanced breast cancer.
- Trial name
- PALINA (NCT02692755)
- Testing
- Palbociclib + Letrozole or Fulvestrant
- Where
- 6 sites in United States
- Volunteers
- 35 people
- Sponsor
- Georgetown University
Diabetes
Enhanced DPP-GLB to Promote Weight Loss Among Nonresponders in a Community-Based Lifestyle Intervention.
This study seeks to establish the efficacy of identifying weight loss nonresponders early in a Diabetes Prevention Program (DPP) intervention in 20 community settings (primarily churches and community centers) and providing them…
- Trial name
- NCT04757519
- Testing
- DPP-GLB Standard, DPP-GLB Enhanced
- Where
- 21 sites in United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Lovoria Williams
Gastroesophageal Reflux Disease, Functional Bowel Disorders
Temple Registry for the Investigation of African American Gastrointestinal Disease Epidemiology
DESCRIPTION: Minimal data exists on the prevalence of gastroesophageal reflux disease in minority populations. Specific objectives of this K24 research project are to: (1) Provide an estimate of the prevalence of gastroesophageal…
- Trial name
- TRIAGE (NCT01262755)
- Testing
- Structured Interview
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Temple University
Alzheimer Dementia, Caregiver
Telephone-delivered Mindfulness Intervention for African American Dementia Caregivers
This study is assesses the feasibility and acceptability of telephone-delivered mindfulness training designed to alleviate caregiver burden for African-American rural caregivers of individuals with moderate to severe dementia, as…
- Conditions
- Alzheimer Dementia, Caregiver, Dementia Alzheimers
- Trial name
- NCT04058886
- Testing
- Telephone-delivered Mindfulness
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections, Mild Cognitive Impairment
Feasibility of the Mindfulness-Based Stress Reduction Intervention for Black Women Living With HIV Supplement
In our Supplement Aim we will conduct a two-arm randomized pilot test of the adapted intervention compared to a usual care control group among 30 African American/Black women with HIV (15/arm) to assess the feasibility and…
- Trial name
- NCT04984681
- Testing
- Mindfulness, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Chronic Kidney Disease
Stress and CKD Among African Americans
The goal of this study is to determine whether experiencing stress from discrimination may increase chronic kidney disease (CKD) progression in African Americans.
- Trial name
- NCT03387319
- Testing
- Racialized Stressful Event Recall, Non-Racialized Stressful Event Recall
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University