Clinical trials: Age 65 and Older
COVID-19
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
The purpose of this study is to evaluate the safety and immunogenicity of a single dose of Sanofi's Omicron subvariant-based Nuvaxovid in participants ≥ 65 years of age and participants 12 through 64 years of age who have at…
- Trial name
- NCT07861542
- Testing
- Omicron Subvariant-Based SARS-CoV-2 Recombinant Spike Vaccine Adjuvanted With Matrix-M
- Where
- 20 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Sanofi
Atrial Fibrillation
Detection of Asymptomatic Atrial Fibrillation in Persons of 65 Year of Age or Older
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although the condition itself is not life-threatening, the complications result in increased morbidity and mortality.
- Trial name
- DETECT AF (NCT04375241)
- Testing
- Subjects with asymptomatic atrial fibrillation will be screened by using a Mobile ECG Device
- Where
- Netherlands
- Volunteers
- 2,168 people, healthy volunteers welcome
- Sponsor
- Diagram B.V.
Vaccination Refusal
A RCT Evaluating an Online Intervention in Increasing Pneumococcal Vaccination Among Older Adults
To evaluate the relative efficacy of an online intervention based on the Trans-theoretical Model delivered by a fully-automated Chatbot with natural language processing functions versus a control in promoting pneumococcal…
- Trial name
- NCT05772117
- Testing
- Chatbot-delivered interventions tailored to stage of changes, Chatbot-delivered standard interventions
- Where
- Hong Kong
- Volunteers
- 374 people
- Sponsor
- Chinese University of Hong Kong
Study is Open to Seniors Age 50 or Older
Impact and Cost of a Pharmacist Pneumococcal Vaccination Program With PNEUMOVAX® 23 at an Urban Senior Center
The overall goals of this program are to measure the impact of a pharmacist pneumococcal vaccine education program (PPVP) using a senior center model of care and provide the pneumococcal vaccine to eligible participants.
- Trial name
- PPVP (NCT01944462)
- Testing
- Pharmacist Pneumococcal Vaccine Program (PPVP)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia
Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia
This phase II trial studies the side effects and how well blinatumomab and combination chemotherapy or dasatinib, prednisone, and blinatumomab work in treating older patients with acute lymphoblastic leukemia.
- Conditions
- Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1, Recurrent Acute Lymphoblastic Leukemia
- Trial name
- NCT02143414
- Testing
- Biopsy Procedure, Biospecimen Collection, Blinatumomab
- Where
- 195 sites in United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Pneumococcal Disease, COVID-19
Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2
Study of the safety and immunogenicity of 20vPnC and a booster dose of BNT162b2 administered at the same visit or each vaccine given alone
- Conditions
- Pneumococcal Disease, COVID-19, SARS-CoV-2 Infection
- Trial name
- NCT04887948
- Testing
- 20-valent pneumococcal conjugate vaccine (20vPnC), BNT162b2, Saline
- Where
- 27 sites in United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Pfizer
Influenza
A Safety and Immunogenicity Trial in Adults 65 Years of Age or Over to Prevent Influenza
The objective of this study is to evaluate the safety of the vaccine and the immune response to the vaccine in healthy adult volunteers 65 years of age or older.
- Trial name
- AVX502-003 (NCT00706732)
- Testing
- AVX502
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AlphaVax, Inc.
Kidney Transplant; Complications, Toxicity
Effect of Tacrolimus Formulation on Neurological Side Effects in Older Kidney Transplant Recipients
Previous studies have shown that elderly patients experience higher trough levels of tacrolimus and are more sensitive to the effects of medications, they experience higher occurrence and severity of such medication related…
- Conditions
- Kidney Transplant; Complications, Toxicity, Drug Toxicity, Neurotoxicity
- Trial name
- NCT03461445
- Testing
- Envarsus, IR Tacrolimus
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, Davis
Aged, Patient Admission
Impact of Collaborative Pharmaceutical Care on Hospital Admission Drug Prescriptions for Patients 65 Years of Age and Older
The primary objective of this study is to evaluate the impact of the implementation of collaborative pharmaceutical care on drug support at admission for patients 65 years of age and older.
- Conditions
- Aged, Patient Admission, Hospitalization
- Trial name
- MEDREV (NCT02598115)
- Testing
- Collaborative Pharmaceutical Care
- Where
- 6 sites in France
- Volunteers
- 622 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Dehydration
Hydration and Outcome in Older Patients
Dehydration is recognised as a major issue in healthcare. Recovery after illness, extended length of stay, pressure sores and slow tissue recovery can all be impacted by dehydration.
- Trial name
- HOOP (NCT01703715)
- Testing
- The Hydrant
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Accidental Falls, Elderly
Fall Risk Prediction and Reduction in Community Ambulators 65 Years of Age or Older
The purpose of this study is to assess the diagnostic efficacy of the Tinetti Assessment, Timed up and Go test (TUG) and Gait Speed on predicting fall risk in adults 65 years of age or greater who are community ambulators.
- Conditions
- Accidental Falls, Elderly, Ambulatory
- Trial name
- NCT00884208
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guthrie Healthcare System
Anticholinergic Adverse Reaction
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
Medications with anticholinergic properties are frequently prescribed for several conditions in older age; for example cardiovascular drugs (e.g. digoxin, furosemide), urologicals (e.g.
- Trial name
- REGENERATE (NCT04660838)
- Testing
- ACB intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Pertussis, Tetanus
A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older
It is well recognized that older adults can contract pertussis, suffer its complications, and unwittingly transmit it to close contacts, which may well include infants too young to have received their primary series of DTaP…
- Conditions
- Pertussis, Tetanus, Diphtheria
- Trial name
- NCT00457249
- Testing
- ADACEL®: Tetanus, Reduced Diphtheria and Acellular Pertussis Adsorbed, DECAVAC®: Tetanus and Diphtheria Toxoids Adsorbed
- Where
- 19 sites in United States
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Sanofi
Stage I Chronic Lymphocytic Leukemia, Stage II Chronic Lymphocytic Leukemia
Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia
This randomized phase III trial studies rituximab with bendamustine hydrochloride or ibrutinib to see how well they work compared to ibrutinib alone in treating older patients with previously untreated chronic lymphocytic…
- Conditions
- Stage I Chronic Lymphocytic Leukemia, Stage II Chronic Lymphocytic Leukemia, Stage III Chronic Lymphocytic Leukemia, Stage IV Chronic Lymphocytic Leukemia
- Trial name
- NCT01886872
- Testing
- Bendamustine Hydrochloride, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 937 sites in United States, Canada
- Volunteers
- 547 people
- Sponsor
- National Cancer Institute (NCI)
Influenza
Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older
The aim of this study is to determine the efficacy of Fluzone High Dose vaccine and that of Fluzone® vaccine in the elderly. Primary objective: To measure the efficacy of the vaccine, defined as the prevention of…
- Trial name
- NCT00976027
- Testing
- Trivalent inactivated influenza vaccine High Dose, Trivalent inactivated influenza vaccine
- Where
- 98 sites in United States, Puerto Rico
- Volunteers
- 9,172 people, healthy volunteers welcome
- Sponsor
- Sanofi
Influenza Immunization, Healthy Volunteers
Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2020-2021 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively
Primary Objective: To provide serum samples (collected from participants before vaccination [Blood Sample 1] and after final vaccination [Blood Sample 2]) to Center for Biologics Evaluation and Research (CBER) for further…
- Trial name
- NCT04551677
- Testing
- Fluzone Quadrivalent vaccine, No Preservative (0.5-mL dose), 2020-2021 formulation, Fluzone High-Dose Quadrivalent vaccine (0.7-mL dose), 2020-2021 formulation
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Clostridoides Difficile Associated Disease
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing the number of C. difficile infections (pCDI) in adults 65 years of age or older.
- Trial name
- BEETHOVEN (NCT07282665)
- Testing
- C.difficile vaccine
- Where
- 185 sites in United States, Argentina and 2 more
- Volunteers
- 32,500 people, healthy volunteers welcome
- Sponsor
- Pfizer