Clinical trials: Age Related Maculopathy
Age-Related Macular Degeneration
A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration
The purpose of this study is to examine the long term safety of an experimental gene transfer agent, RetinoStat®, designed to treat neovascular age-related macular degeneration.
- Trial name
- NCT01678872
- Testing
- RetinoStat
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Oxford BioMedica
Age Related Macular Degeneration (ARMD)
EFFECT:Eccentric Fixation From Enhanced Clinical Training
Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in the UK, Europe and N America. Low vision patients with AMD have great difficulty reading, which leads to a loss of independence and…
- Trial name
- EFFECT (NCT01499628)
- Testing
- Supervised Reading, EVT at the PRL, EVT at the TRL
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Cataract, Age Related Macular Degeneration
Polarization Perception in Health and Disease. Testing a New Sight Test
A study to assess the utility of human polarization pattern perception for the detection, diagnosis and monitoring of eye disease
- Conditions
- Cataract, Age Related Macular Degeneration, Pseudophakia, Macular Disease
- Trial name
- TaNSiT (NCT03823092)
- Testing
- polarization sensitivity
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- South Warwickshire NHS Foundation Trust
Dry Age-related Macular Degeneration, Vision Impairment and Blindness
Vision Improvement for Legally Blind Dry AMD Patients
This retrospective observational study is intended to assess the feasibility of using a nonsignificant risk device for vision improvement for legally blind dry AMD patients.
- Trial name
- NCT04875234
- Testing
- Clear-K Low Vision Aid Treatment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Optimal Acuity Corporation
Exudative Age-related Macular Degeneration
Plasma Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Injection of Aflibercept
The purpose of this study is to examine the plasma concentration of vascular endothelial growth factor (VEGF) after standard treatment with one of the newest growth factor inhibitors, aflibercept (Eylea).
- Trial name
- Eylea-2014 (NCT02125864)
- Testing
- intravitreal injection
- Volunteers
- 16 people
- Sponsor
- Oslo University Hospital
Geographic Atrophy, Age-related Macular Degeneration
Micropulse Laser for Geographic Atrophy
Geographic atrophy (GA) causes the loss of the retinal pigment epithelium (RPE) cells in broad areas of the retina. The application of subthreshold micropulse laser spots in healthy RPE in the vicinity of the area of GA may…
- Trial name
- MPL4DRY (NCT01799564)
- Testing
- Micropulse
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Institut de la Macula y la Retina
Age-Related Macular Degeneration
Triamcinolone Acetonide in Patients With Serous Pigment Epithelial Detachment
The purpose of this study is to determine the effectiveness and safety of triamcinolone acetonide in patients with serous pigment detachment associated with age-related macular degeneration
- Trial name
- COAST_UA_AMD (NCT04292756)
- Testing
- Subtenon injection of 40 mg triamcinolone acetonide, Intravitreal injection of 4 mg triamcinolone acetonide, Visometry
- Where
- 4 sites in Ukraine
- Volunteers
- 63 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Neovascular Age-Related Macular Degeneration (nAMD)
A Clinical Study of QL1207H Injection Versus Aflibercept for Neovascular Age-related Macular Degeneration
The goal of this clinical trial is to evaluate the efficacy and safety of QL1207H injection versus aflibercept 8 mg in patients with neovascular age-related macular degeneration.
- Trial name
- NCT07489586
- Testing
- QL1207H injection, Aflibercept 8 mg
- Volunteers
- 356 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Age-Related Macular Degeneration
Study of PF-04523655 (REDD14NP) In Subjects With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (Wet AMD)
The aim of the study is to evaluate whether PF-04523655 is safe in the treatment of neovascular/wet AMD
- Trial name
- NCT00725686
- Testing
- PF-04523655
- Where
- 11 sites in United States, Israel
- Volunteers
- 54 people
- Sponsor
- Quark Pharmaceuticals
Neovascular Maculopathy, Age Related Macular Degeneration
Anti-VEGFR Vaccine Therapy in Treating Patients With Neovascular Maculopathy
The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 or A*0201 restricted epitope peptides VEGFR1 and VEGFR2 emulsified with Montanide ISA 51 in patients with Neovascular Maculopathy…
- Trial name
- NCT00791570
- Testing
- VEGFR1 and VEGFR2
- Where
- Japan
- Volunteers
- 17 people
- Sponsor
- Osaka University
Choroidal Neovascularization, Myopia
Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD
Anti-VEGF therapy has been proven efficacious for the wet (neovascular) form of macular degeneration and may be beneficial for the treatment of choroidal neovascularization (CNV) due to other causes.
- Conditions
- Choroidal Neovascularization, Myopia, Punctate Inner Choroidopathy (PIC), Multifocal Choroiditis
- Trial name
- CNV (NCT01256580)
- Testing
- Bevacizumab (Avastin; Genentech, Inc.), Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy
- Sponsor
- Massachusetts Eye and Ear Infirmary
Neovascular (Wet) Age-Related Macular Degeneration
First in Human Study of BETA-TT8 in wetAge-related Macular Degeneration (wetAMD)
This is a first-in-human clinical trial evaluating the safety and tolerability of BETA-TT8 Ophthalmic Gel in people with wet age-related macular degeneration (AMD).
- Trial name
- BEyOND (NCT07766473)
- Testing
- BETA-TT8 ophthalmic gel 3.8% w/v
- Where
- 4 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Filamon LTD
Neovascularization, Choroidal, Macular Degeneration, Age-Related
Study to Evaluate Faricimab (RO6867461; RG7716) for Extended Durability in the Treatment of Neovascular Age Related Macular Degeneration
This was a Phase II, multicenter, randomized, active comparator-controlled, 52-week study to investigate the efficacy, safety and pharmacokinetics of faricimab (RO6867461; RG7716) administered with extended dosing regimens in…
- Trial name
- STAIRWAY (NCT03038880)
- Testing
- Faricimab, Ranibizumab
- Where
- 25 sites in United States
- Volunteers
- 76 people
- Sponsor
- Hoffmann-La Roche
Exudative Age Related Macular Degeneration
The Spectralis-Cirrus Study
Retinal thickness measurement is one of the most important examinations in the follow up of exudative age-related macular degeneration.
- Trial name
- NCT00927303
- Testing
- Cirrus-Spectralis, Spectralis-Cirrus
- Where
- Austria
- Volunteers
- 110 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Intermediate Age-Related Macular Degeneration
Eggs and Age-related Macular Degeneration (EggsAMD) Study.
Age-related macular degeneration (AMD) is the primary cause of vision loss in people over the age of 55. Currently, no cure is available for individuals suffering from AMD.
- Trial name
- EggsAMD (NCT07021027)
- Testing
- Whole Egg - 4, Whole Egg - 2
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kathryn Starr
Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema
Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and Safety
This randomized controlled trial compares two techniques for eyelid retraction during intravitreal injection (IVI): an adjustable solid-blade eyelid speculum (Group A) and single-hand retraction of the upper eyelid with one…
- Conditions
- Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema, Retinal Vein Occlusion, Intravitreal Injections
- Trial name
- IVI-RETRACT (NCT07481500)
- Testing
- Eyelid Speculum Retraction, Cotton-Tipped Applicator Retraction
- Where
- Thailand
- Volunteers
- 129 people
- Sponsor
- Jakkrit Juhong
Neovascular Age-related Macular Degeneration
Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)
This is a phase 1/2 clinical study to evaluate the safety, preliminary efficacy, immunogenicity, and pharmacokinetic (PK) characteristics of SKG0106 in subjects with nAMD.
- Trial name
- NCT05986864
- Testing
- SKG0106
- Where
- 9 sites in United States, China
- Volunteers
- 68 people
- Sponsor
- Skyline Therapeutics (US) Inc.
Neovascular Age-Related Macular Degeneration
Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD
The objective of this study is to provide initial safety, tolerability and pharmacokinetics information of intravitreal administration of pegcetacoplan in order to support further development into larger Phase II studies for…
- Trial name
- ASAP II (NCT02461771)
- Testing
- Pegcetacoplan
- Where
- 4 sites in United States, Australia
- Volunteers
- 13 people
- Sponsor
- Apellis Pharmaceuticals, Inc.
AMD
TAB014(Drug Code) in Wet( Neovascular)Age-related Macular Degeneration(AMD) Subjects
Subjects with secondary wet age-related macular degeneration(AMD) or recurrent subfoveal choroidal neovascularization (CNV) in only one study eye will be enrolled into the study.
- Trial name
- NCT03675880
- Testing
- TAB014
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Lee's Pharmaceutical Limited
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