Clinical trials: Aged Skin
Ageing
Human Skin Aging: Clinical Parameters and Gene Expression Profiling
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.
- Trial name
- GEP (NCT01451476)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pruritus
Efficacy of CeraVe® Moisturizing Cream on Skin Pruritus in Elderly Patients
The goal of this clinical trial is to evaluate the CeraVe® moisturizing cream's efficiency on the improvement of skin barrier in patients with chronic elderly pruritus.
- Trial name
- NCT05779150
- Testing
- CeraVe® Moisturising Cream, Standard Cream
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Polymyositis, Dermatomyositis
Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy
Trial to Evaluate the Efficacy and Safety of Abatacept subcutaneous (SC) in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy
- Conditions
- Polymyositis, Dermatomyositis, Autoimmune Necrotizing Myopathy, Overlap Myositis
- Trial name
- NCT02971683
- Testing
- Abatacept subcutaneous
- Where
- 79 sites in United States, Australia and 9 more
- Volunteers
- 149 people
- Sponsor
- Bristol-Myers Squibb
Cicatrix, Wound Healing
Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites
The purpose of this study is to investigate the accelerated-healing potential of injection or injection plus topical application of Juvista to minor split skin grafts (SSG).
- Trial name
- NCT00984503
- Testing
- Avotermin
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Renovo
Pain, Fear
Effect of Helfer Skin Tap and Vibration on Pain and Fear in Children During Intramuscular Injection
Intramuscular injection is one of the most common invasive procedures in childhood and is frequently associated with pain and fear.
- Trial name
- NCT07468227
- Testing
- Helfer skin tab, Vibration Buzzy Bee
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people
- Sponsor
- Ege University
Breast Cancer
Adjuvant Hormone Therapy in Treating Women With Operable Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002460
- Testing
- goserelin acetate, tamoxifen citrate, ablative endocrine surgery
- Where
- 34 sites in Belgium, United Kingdom
- Sponsor
- Cancer Research UK
Atopic Dermatitis
5-Year Safety Study of Pimecrolimus Cream 1% in Infants 3 - 12 Months of Age With Mild to Moderate Atopic Dermatitis
The primary purpose of this study is to investigate the safety of pimecrolimus cream 1% in the long-term treatment (up to 5 years) of atopic dermatitis (eczema) in patients less than 12 months of age compared to topical…
- Trial name
- NCT00120523
- Testing
- Pimecrolimus, Topical corticosteroids
- Where
- 31 sites in United States, Germany
- Volunteers
- 2,418 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Genetics, Skin Aging
Relationship of Skin Related SNP to Topical Skin Care Product
Demonstrate the relationship between single nucleotide polymorphisms (SNP) and response to a topical skin care product.
- Trial name
- NCT03446079
- Testing
- Topical Anti Aging Cream
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- HelicalCodeMD
Atopic Dermatitis
Dupilumab in Japanese Patients With Atopic Dermatitis
Primary Objective: To evaluate the efficacy of dupilumab administered concomitantly with topical corticosteroids (TCS) Secondary Objective: To evaluate the efficacy of dupilumab administered concomitantly with TCS.
- Trial name
- NCT04678882
- Testing
- Dupilumab SAR231893
- Where
- 19 sites in Japan
- Volunteers
- 62 people
- Sponsor
- Sanofi
Breast Neoplasms, HER2/Neu Positive
Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer
This phase II trial studies the side effects and how well lapatinib ditosylate and trastuzumab work in treating older patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer that has spread from where…
- Conditions
- Breast Neoplasms, HER2/Neu Positive, Geriatric Health Services
- Trial name
- NCT01273610
- Testing
- Lapatinib, Trastuzumab, laboratory biomarker analysis
- Where
- 8 sites in United States
- Volunteers
- 40 people
- Sponsor
- City of Hope Medical Center
Skin Aging
Multicenter, Prospective Study to Determine the Performance and Safety of the New M-HA30 Architect Device on the Quality of the Skin: HEBE8 Study
For skin rejuvenation the targeted population does not present a specific pathology. Aesthetic procedures are requested by the patient to improve appearance, look younger and feel better.
- Trial name
- HEBE8 (NCT07007351)
- Testing
- Intradermal injection
- Where
- France
- Volunteers
- 285 people
- Sponsor
- Laboratoires FILLMED
Age Macular Degeneration
Study of the Macular Pigment by the Consumption of Corn With Strong Content in Zeaxanthine
The Age Macular Degeneration (AMD) is the first cause of blindness in industrialized countries. The macular pigment (lutein and zeaxanthin) could play an important role in the arisen of the AMD.
- Trial name
- MAIS (NCT02113254)
- Testing
- Corn zeaxanthin
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Breast Cancer
'ADVANCE' (A Pilot Trial)
This study is being conducted to carefully study how chemotherapy is tolerated in group of patients age 70.
- Trial name
- NCT03858322
- Testing
- Paclitaxel, Cyclophosphamide, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Dana-Farber Cancer Institute
Skin Aging, Skin Wrinklings
Facial Cosmetic Acupuncture on Skin Rejuvenation
Facial Cosmetic Acupuncture technique includes wrinkles, acupoints and muscle points on the face, head and neck. This study is designed to determine the efficacy and safety of Facial Cosmetic Acupuncture on skin rejuvenation.
- Trial name
- NCT01486303
- Testing
- Facial Cosmetic Acupuncture
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Kyunghee University
Elderly Females, HER2 + Breast Cancer
Olaparib+Trastuzumab+Pertuzumab Neoadjuvant for Elderly HER2+ Breast Cancer
This is a single-center, interventional, prospective clinical study. A total of 45 patients aged ≥ 60 years with ECOG PS 0-1 who have histologically confirmed, treatment-naïve, unilateral primary invasive HER-2-positive breast…
- Conditions
- Elderly Females, HER2 + Breast Cancer, Neoadjuvant Therapy
- Trial name
- NCT07695259
- Testing
- olaparib combined with trastuzumab and pertuzumab
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Wen-Ming Cao
Skin Aging
Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin®) in Treatment of Expression Wrinkles in the Upper Third of the Face
The purpose of this study is to determinate whether Xeomin® (Botulinum toxin Type A) is safe, effective and tolerable in woman aged 30 to 50 years old for treatment of mild, moderate or severe expression lines (wrinkles) in the…
- Trial name
- XEO-001/07 (NCT00986570)
- Testing
- Botulinum Toxin A
- Where
- Brazil
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Active Juvenile Psoriatic Arthritis
Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis
The study will aim to estimate the efficacy of apremilast compared with placebo in the treatment of juvenile psoriatic arthritis (JPsA) in pediatric participants 5 to less than 18 years of age.
- Trial name
- PEAPOD (NCT04804553)
- Testing
- Apremilast
- Where
- 44 sites in Belgium, France and 12 more
- Volunteers
- 60 people
- Sponsor
- Amgen
Breast Cancer
Performance of MammoAlert™, Point of Care System, for the Screening of Breast Cancer in Women 18 Years of Age or Older
POC Medical Systems has developed a Point of Care system for the screening of breast cancer in the general population. Via a proprietary algorithm, the MammoAlert™ is expected to determine breast cancer's risk level for a subject…
- Trial name
- NCT03243877
- Testing
- MammoAlert Screening Test
- Where
- 7 sites in India
- Volunteers
- 2,458 people
- Sponsor
- POC Medical Systems, Inc.
Operable Breast Neoplasms
Trial of Endocrine Against Locoregional Therapy First in Postmenopausal Women With Early Breast Cancer
The hypothesis to be addressed in this randomized phase III trial is that 4 months of letrozole may be superior to surgery as primary therapy for early stage hormone receptor positive breast cancer in postmenopausal women…
- Trial name
- REAL (NCT00908531)
- Testing
- letrozole (Femara)
- Where
- 9 sites in Denmark
- Volunteers
- 123 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Breast Cancer
Addtional Effect of Hyperbaric Oxygen to Programmed Physical Activity on Musckoloskeletal Pain in Breast Cancer Elderly
patienst who survived from breast cancer are prescribed long administraion of aromatase inhbitors.. these inhibitors usually induce musckloskeletal pains.
- Trial name
- NCT07662629
- Testing
- hyperbaric therapy and exercise, exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University