Clinical trials: Ageing
Cardiovascular Diseases
Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function
The purpose of this study is to determine if treatment with a drug called fenofibrate, which is a PPAR-alpha agonist and controls how the heart metabolizes fats, will reverse the age-related decline in cardiac fat metabolism and…
- Trial name
- PPAR (NCT00627653)
- Testing
- fenofibrate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Anemia, Clonal Hematopoiesis
Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly
The prevalence and incidence of anemia tend to increase with advancing age. Relatively low hemoglobin concentrations are a common laboratory finding in the elderly, for the most part judged by physicians as a sign without…
- Trial name
- NCT03907553
- Testing
- targeted genome sequencing
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Depression in Old Age
Programme Evaluation on Effectiveness of The Use of Movement-based x 'Elderspirituality - Fu Le Mun Sum' Intervention to Support Elderly People With Depressive Symptoms
Depression is one of the most common mood disorders in old age, and yet it is frequently under-detected and under-treated. Adopting a train-the-trainer approach, this project intends to utilize the dance movement therapy (DMT)…
- Trial name
- NCT05308082
- Testing
- Dance Movement Therapy (DMT)
- Where
- Hong Kong
- Volunteers
- 135 people
- Sponsor
- The University of Hong Kong
Aging, Undernutrition
Determination of In-vivo Plasma AA Appearance From Plant Protein Fibre Products
This study aims to assess the digestibility and efficacy of the study groups previously developed innovative plant-based protein and fibre products.
- Conditions
- Aging, Undernutrition, Appetite Loss, Age-Related Sarcopenia
- Trial name
- NCT05420142
- Testing
- Net peripheral AA appearance following ingestion of 3 selected PPF products compared to whey
- Where
- 2 sites in Ireland, Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Wrinkles, Ageing
Assessment of the Impact of a Coenzyme Q10 Supplementation on the Skin
Objective of the study is to determine the influence of dietary supplementation with coenzyme Q10 (CoQ10) on skin conditions. 33 healthy female subjects will be randomly assigned to a placebo group, a low-dose (LD) group…
- Conditions
- Wrinkles, Ageing, Photoprotection
- Trial name
- NCT02604641
- Testing
- Quvital LD group, Quvital HD group
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Physical Activity, Aging
Independent Walking for Brain Health
Physical activity interventions with older adults can improve brain health; however most interventions have been performed in gym-like settings that reach a small sector of the senior population.
- Trial name
- NCT03058146
- Testing
- Mobile Health Walking Condition, Healthy Aging Education Condition
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Deglutition Disorders
Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging
Oropharyngeal dysphagia (OD) is the most frequent digestive disorder in older people (>70 years) and has been recently recognized as a geriatric syndrome.
- Trial name
- NCT03050957
- Testing
- menthol
- Volunteers
- 38 people
- Sponsor
- Hospital de Mataró
Healthy Volunteers, Non-Healthy/Non-Frail
Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)
Background: Biomarkers are substances in people's blood and tissues. They help researchers understand diseases and signs of aging.
- Conditions
- Healthy Volunteers, Non-Healthy/Non-Frail, Frail
- Trial name
- NCT02339012
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging
Enhancing Function in Later Life: Exercise and Functional Network Connectivity
Physiological and neurocognitive changes experienced as a result of increasing age may influence socioemotional functioning and economic behaviors, yet, the mechanisms through which these changes occur are not well understood.
- Trial name
- FORCE (NCT02068612)
- Testing
- Moderate Intensity Continuous Training+Interval Training, Low Intensity Continuous Training
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Stress, Ageing
The Relaxation vs. Retreat Study
The purpose of this research study is to examine whether a short term meditation intervention can improve health, mood, and biological markers of cellular stress and aging in novice and experienced meditators compared to controls.
- Conditions
- Stress, Ageing, Wellbeing
- Trial name
- R&R (NCT01857830)
- Testing
- Meditation Retreat, Active Comparator Relaxation Group
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vulvo Vaginal Atrophy
Regenerative Treatment of Female Genital Atrophy
Vulvovaginal health is a key aspect of active and healthy aging for all women. Hormonal deprivation that occurs during menopause significantly affects the anatomy and function of urogenital tissues, leading to their atrophy.
- Trial name
- RETREAT-FUGA (NCT07306611)
- Testing
- Mesotherapy with Autologous Platelet-Rich Plasma (PRP) to vulvovaginal area, Mesotherapy with saline solution, Platelet-Poor Plasma Gel
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- AndreiaAntunes
Memory
Resveratrol for Improved Performance in the Elderly
The investigators aim to conduct a randomized placebo controlled pilot study to determine whether resveratrol, a dietary ingredient, supplementation is safe and improves memory and physical performance in older adults.
- Trial name
- RIPE (NCT01126229)
- Testing
- Low dose Resveratrol, High dose Resveratrol
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Body Temperature Changes, Heat Stress
Consecutive Occupational Heat Exposure With and Without Overnight Cooling
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07656519
- Testing
- Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Parkinson Disease
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease
BioGenParkinson is an observational, prospective cohort study evaluating biomarkers of Parkinson's Disease (PD) progression in community-dwelling subjects aged 65 years or more, consecutively referring to INRCA outpatient clinic…
- Trial name
- BioGenPark (NCT05384522)
- Testing
- blood samples collection
- Volunteers
- 103 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Aging
The Effect of Strength Training and Protein Supplementation in Old Pre-frail Individuals
The aim of this study is to investigate the effects of a lower-body strength training regime combined with protein supplementation in pre-frail elderly individuals.
- Trial name
- NCT03723902
- Testing
- Heavy-load strength training, Protein supplementation
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Muscle Loss
The Effect of Leucine on Carnitine Transport to Skeletal Muscle
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.
- Trial name
- ROL (NCT05009654)
- Testing
- L-carnitine, L-leucine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Skin Laxity, Facial Aging
RESTRUCTURING THE MANDIBULAR ANGLE IN FACIAL AGING: A NOVEL TECNIQUE USING POLY-L-LACTIC ACID
Skin laxity is a common complaint among patients seeking aesthetic dermatological interventions, affecting the facial contour, especially in the mandibular angle, due to bone aging and the loss of tissue support in the lower…
- Trial name
- NCT06948045
- Testing
- PLLA application to the mandibular angle
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Doris Hexsel
Mild Cognitive Impairment
Effects of Brain Training Games on Cognitive Function and Quality of Life in MCI
The study aims to determine the effects of brain training games on cognitive function and Quality of life among older adults with MCI.
- Trial name
- NCT06437704
- Testing
- Brain training game Lumosity, Simulation game simcity buildit
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Aging
A Study to Evaluate Efficacy of Dietary Ingredient in Vitality and Metabolic Factors in Healthy Individuals
The present study is a randomized, placebo-controlled, feasibility study to evaluate efficacy of dietary ingredients in vitality \& metabolic factors in healthy individuals.
- Trial name
- NCT06188949
- Testing
- Dolichos biflorus (Horsegram) seed extract, Carica papaya leaves extract
- Where
- 2 sites in India
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.