Clinical trials: Aggressive Fibromatosis
Relapsed Pediatric Solid Tumors, Refractory Pediatric Solid Tumors
MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors
The purpose of this study is to determine if Magnetic Resonance guided High Intensity Focused Ultrasound ablative therapy is safe and feasible for children, adolescents, and young adults with refractory or relapsed solid tumors.
- Conditions
- Relapsed Pediatric Solid Tumors, Refractory Pediatric Solid Tumors, Rhabdomyosarcoma, Ewing Sarcoma
- Trial name
- NCT02076906
- Testing
- Magnetic Resonance High Intensity Focused Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- AeRang Kim
Desmoid Tumor
Toremifene in Treating Patients With Desmoid Tumors
RATIONALE: Estrogen can stimulate the growth of cancer cells. Hormone therapy using toremifene may fight the growth of desmoid tumors by reducing the production of estrogen.
- Trial name
- NCT00002595
- Testing
- toremifene, conventional surgery
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Advocate Lutheran General Hospital
Desmoid Tumors
Cryoablation for Advanced and Refractory Desmoid Tumors
Desmoid tumors, also called aggressive fibromatosis, are rare, locally invasive tumors with no potential for metastasis. The incidence is approximately 2 to 4 per million per year in the general population.
- Trial name
- CARDT (NCT06113094)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Desmoid Fibromatosis
Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis
This randomized phase III trial compares the effects, good and/or bad, of sorafenib tosylate in treating patients with desmoid tumors or aggressive fibromatosis.
- Trial name
- NCT02066181
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Sorafenib Tosylate
- Where
- 150 sites in United States, Canada
- Volunteers
- 87 people
- Sponsor
- National Cancer Institute (NCI)
Desmoid Tumor, Desmoid-type Fibromatosis
Quality of Life of Patients With Desmoid-type Fibromatosis
Rationale: Desmoid-type fibromatosis (DTF) is a rare, histologically benign, soft tissue tumour. Although incapable of metastasizing, the clinical course is unpredictable and can be aggressive because of local invasive growth.
- Trial name
- QUALIFIED (NCT04289077)
- Testing
- Questionnaires
- Where
- 4 sites in Netherlands, United Kingdom
- Volunteers
- 156 people
- Sponsor
- Erasmus Medical Center
Solid Neoplasms, Colorectal Neoplasms
A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC)
This study will be conducted to assess the safety and tolerability of E7386 in participants with solid tumor including CRC.
- Conditions
- Solid Neoplasms, Colorectal Neoplasms, Gastrointestinal Tumors
- Trial name
- NCT03833700
- Testing
- E7386
- Where
- 8 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Eisai Co., Ltd.
Desmoid Tumor
Study of Cryoablation and Nirogacestat for Desmoid Tumor
The primary purpose of this protocol is Systemic therapy with oral study agent, nirogacestat, followed by a single cryoablation procedure.
- Trial name
- NCT05949099
- Testing
- Nirogacestat, Cryoablation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Nam Bui
Desmoid-Type Fibromatosis
Immunological Phenotype of Desmoid-fibromatosis-affected Patients.
This observational study aims to characterize the molecular, phenotypic, and functional inflammatory and immunological profile of patients with sporadic desmoid-type fibromatosis undergoing either active surveillance or systemic…
- Trial name
- NCT07496242
- Where
- 8 sites in Italy, Netherlands
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Desmoid, Desmoid Fibromatosis of Skin
Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis
In this study Drug-eluting microbeads (DEB) loaded with Doxorubicin will be delivered into the target Desmoid Fibromatoses (DF) tissue via selective arterial embolization by angiographic technique.
- Conditions
- Desmoid, Desmoid Fibromatosis of Skin, Desmoid Neoplasm of Chest Wall, Desmoid Tumor Caused by Somatic Mutation
- Trial name
- NCT03966742
- Testing
- Drug Eluting Bead Embolization (DEB) for Desmoid Fibromatosis
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rabin Medical Center
Desmoid Tumor
Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting
"Wait \& see" is currently the standard of care of recently diagnosed desmoid tumors (DT). In case of progression or symptomatic disease, medical therapy is nowadays widely used including chemotherapy.
- Trial name
- CRYODESMO-02 (NCT06081400)
- Testing
- Cryoablation, Chemotherapy drug
- Where
- 13 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Lung, Prostate, Breast, Colon, Pancreatic, Renal, Bladder,Thyroid, Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut) Cancer, Cancer of the Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut), Sarcoma Cancer
Optional Sub-study to Intraoperative Imaging With ICG Registry
The primary goal of this optional sub-study is to record what tissues fluoresce in the operating room, and then to identify if these lesions are cancer when the histopathology is performed.
- Conditions
- Lung, Prostate, Breast, Colon, Pancreatic, Renal, Bladder,Thyroid, Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut) Cancer, Cancer of the Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut), Sarcoma Cancer, Cancer of Neuro-onc, Parathyroid, Desmoid Tumors, Melanoma Cancer
- Trial name
- NCT02651246
- Testing
- data collection
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cancer Diagnosis, Non-Metastatic Neoplasm
PRISM for Depression and Anxiety in Young Adults With Cancer
This research study is being done to test the feasibility of an existing supportive program (PRISM) to address psychological symptoms (i.e., depressive and anxiety symptoms) that young adult participants diagnosed with cancer or…
- Conditions
- Cancer Diagnosis, Non-Metastatic Neoplasm, Anxiety, Anxiety Disorders
- Trial name
- PRISM (NCT06502483)
- Testing
- Promoting Resilience in Stress Management Program
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Dana-Farber Cancer Institute
Aggressive Fibromatosis
National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis (ALTITUDES)
The purpose of this study is to constitute the French largest Aggressive fibromatosis cohort.
- Trial name
- ALTITUDES (NCT02867033)
- Testing
- biopsy, biobank constitution, Coloscopy
- Where
- 39 sites in France
- Volunteers
- 628 people
- Sponsor
- Centre Oscar Lambret
Advanced Desmoid Tumor, Advanced Chondrosarcoma
Imatinib in Patients With Desmoid Tumor and Chondrosarcoma
The purpose of this study is to determine whether Imatinib Mesylate is active in diseases - such as Desmoid Tumor and Chondrosarcoma - expressing the receptor for the platelet-derived growth factor (PDGF) both in its isoform…
- Trial name
- Basket 1 (NCT00928525)
- Testing
- Imatinib Mesylate
- Where
- 7 sites in Italy
- Volunteers
- 35 people
- Sponsor
- Italian Sarcoma Group
Fibromatosis
A Trial of Imatinib for Patients With Aggressive Desmoid Tumor (Aggressive Fibromatosis)
Aggressive fibromatosis (AF, also known as desmoid tumor) is a fibroproliferative neoplasm that typically arises in the abdomen but can develop at other anatomic sites, most commonly in the extremities.
- Trial name
- NCT02495519
- Testing
- Imatinib
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Yonsei University
Childhood Alveolar Soft-part Sarcoma, Childhood Angiosarcoma
Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas
This research trial studies genes in tissue samples from younger and adolescent patients with soft tissue sarcomas. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about…
- Conditions
- Childhood Alveolar Soft-part Sarcoma, Childhood Angiosarcoma, Childhood Desmoplastic Small Round Cell Tumor, Childhood Epithelioid Sarcoma
- Trial name
- NCT01567046
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Oncology Group
Desmoid Tumor
Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059
Phase I, open-label, non-randomized study to evaluate safety of BC2059 administered intravenously to subjects with proven primary or recurrent desmoid tumor that is unresectable and symptomatic or progressive.
- Trial name
- NCT03459469
- Testing
- Tegavivint
- Where
- 7 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- Iterion Therapeutics
Soft Tissue Sarcoma, Desmoid Tumors
HIFU Ablation of Soft Tissue Sarcoma
Around 3,300 people are diagnosed with soft tissue sarcoma (STS) each year in the UK, and a significant proportion of STS diagnoses are in people aged under 30 years.
- Trial name
- SarcAblate (NCT05111964)
- Testing
- High Intensity Focused Ultrasound Ablation, Tumour Biopsy and Venous Blood Tests
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Oxford University Hospitals NHS Trust