Clinical trials: Aging Frailty, open to volunteers
Frailty, Geriatrics
Strength-based Tailored-Exercise Program at Home for Geriatric Patients
This study focuses on the "Strength-based Tailored-Exercise Program at Home (STEP@Home)" aimed at improving health outcomes for geriatric patients at risk of hospitalization-associated functional decline.
- Trial name
- NCT06820021
- Testing
- Strength-based Tailored-Exercise Program at Home (STEP@Home), Physical activity education
- Where
- Hong Kong
- Volunteers
- 256 people
- Sponsor
- The University of Hong Kong
Community Dwelling Individuals Aged 50 and Over
Identification of Frailty Predictors of Adverse Health Outcomes in Community-dwelling Individuals Aged 50 and Over
Introduction. Although ageing is a general phenomenon, a great inter individual variability on the quality of ageing can be observed.
- Trial name
- SUCCEED (NCT04603144)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Frailty, Sarcopenia
Effect of a Multicomponent Therapeutic Exercise Program in Primary Care on Frailty and Sarcopenia in Older Adults
Background: Frailty and sarcopenia are common conditions in older adults that increase the risk of disability, dependence, and hospitalizations.
- Conditions
- Frailty, Sarcopenia, Aging, Exercises Therapy
- Trial name
- FRACTEP-65 (NCT07132632)
- Testing
- 12-week multicomponent therapeutic exercise program including supervised and home-based sessions focused on strength, balance, mobility, and aerobic capacity
- Volunteers
- 60 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Fall Prevention, Autonomy of Older People
Advanced Practice Nurses for Fall Incidence PrevenTion in Very Old Robust Adults
APN-FIT is a hybrid type 1 clinical trial comparing the effect of an APN delivered fall prevention programme with standard care in non-frail patients.
- Conditions
- Fall Prevention, Autonomy of Older People, Frail Elderly, Advanced Practice Nursing
- Trial name
- APN-FIT (NCT06617806)
- Testing
- Follow-up by the Advanced Practice Nurse
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Nantes University Hospital
Aging Frailty
Integration of Clinical, Biological and Psycho-social Variables for a Gender-sensitive Frailty Prediction
The progressive aging of the population worldwide yields profound health and social implications. Aging entails a progressive impairment of functions and, ultimately, leads to increased susceptibility to morbidity and mortality.
- Trial name
- AGE-IT (NCT07109596)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Aging, Frailty
Effect of Gut Microbiome Intervention on Aging Via Oral FMT
A severe public health issue facing global population is aging. Increasing preclinical and clinical data indicate the contribution of gut microbiome on aging and aging-related diseases such as cardiovascular disease, Alzheimer…
- Trial name
- STEP-aging (NCT05598112)
- Testing
- FMT capsules
- Where
- 6 sites in China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Frailty, Frailty in Older Adults
ENRICH Study: A Mixed-methods Feasibility Study of a Nurse-led Model of Care for Social Frailty in Philippine Primary Care
The ENRICH Study is a single-arm, single-site, mixed-methods feasibility and pilot implementation study examining a culturally adapted, nurse-led model of care for social frailty among community-dwelling older adults in one…
- Conditions
- Frailty, Frailty in Older Adults, Frailty in Aging
- Trial name
- ENRICH (NCT07861997)
- Testing
- Group activities (i.e., low impact exercise), peer counseling, volunteering, Social Frailty Care Bundle (SFCB)
- Where
- Philippines
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Healthy Aging, Sarcopenia
Plant-based Diets and Healthy Aging
This prospective study investigates the health effects of vegetarian and plant-based diets in middle-aged and older adults in Taiwan, specifically, recruiting 5000 Tzu Chi volunteers.
- Conditions
- Healthy Aging, Sarcopenia, Frailty, Cognitive Decline
- Trial name
- TCAS (NCT07151365)
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Frailty
A Study of Human Allogeneic Bone-marrow-derived Mesenchymal Stromal Cell Product (StromaForte) in Patients With Aging Frailty
The goal of this phase I/II clinical trial is to evaluate the safety and tolerability of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in patients with aging frailty.
- Trial name
- NCT06070532
- Testing
- Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- The Bahamas
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cellcolabs Clinical LTD.
Aging, Healthy Aging
FAXAGE: Fasting And Exercise To Slow Aging In Humans
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise…
- Conditions
- Aging, Healthy Aging, Aging Frailty
- Trial name
- FAXAGE (NCT07207044)
- Testing
- Exercise - Strength + Cardio, Time-restricted feeding, Time-restricted feeding + Exercise
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
HIV, Aging
Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older
The primary objective of this study is to identify and characterize frailty and pre-frailty in persons age 50 and older living with human immunodeficiency virus (HIV) followed by the Atrium Health Wake Forest Baptist Infectious…
- Trial name
- NCT05858034
- Testing
- Customized activity plan, Customized nutrition plan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Frailty, Mild Cognitive Impairment
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction.
- Conditions
- Frailty, Mild Cognitive Impairment, Aging
- Trial name
- Mito-Frail (NCT06027554)
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- UConn Health
Ageing Well
Eccentric Exercise in Community-dwelling Older Adults
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of a 12-month eccentric-biased strengthening programme in community-dwelling older adults aged 65 years and older.
- Trial name
- HEX:AGEUK (NCT07916935)
- Testing
- Eccentric exercise intervention
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Northampton
Frailty, Intrinsic Capacity
Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore
This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore.
- Conditions
- Frailty, Intrinsic Capacity, Lifestyle
- Trial name
- SPICE (NCT07525583)
- Testing
- ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway)
- Where
- Singapore
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Frailty, Ageing Well
Healthy Older Adults Through Movement and Engagement
The HOME Project evaluates the effects of structured health dialogues with individuals aged 67-84 years in the municipality of Borgholm, Sweden.
- Conditions
- Frailty, Ageing Well, Prevention Intervention, Health Related Quality of Life
- Trial name
- HOME (NCT07136168)
- Testing
- Health dialogue
- Where
- Sweden
- Volunteers
- 2,952 people, healthy volunteers welcome
- Sponsor
- Linkoeping University