Clinical trials: Agitated Behaviour
Agitated; State, Acute Reaction to Stress
Preemptive Chlorepheniramine Maleate Reducing Postoperative Agitation
The aim of the study is to identify the role of preoperative chlorepheniramine maleate on alleviating or reducing the severity of postoperative agitation following FESS procedures.
- Trial name
- NCT04293081
- Testing
- Preemptive chlorepheniramine maleate intravenous injection, normal saline
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Advanced Malignant Neoplasm, Delirium
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
This randomized phase II/III trial studies how well haloperidol with or without chlorpromazine works in treating delirium in patients with cancer that has spread to other parts of the body or has come back.
- Conditions
- Advanced Malignant Neoplasm, Delirium, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm
- Trial name
- NCT03021486
- Testing
- Chlorpromazine, Haloperidol, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Dementia
The Effects of White Noise on Agitated Behaviors and Cortisol Level in Saliva Among the Patients With Dementia
The purpose of this study will be to examine the effects of white noise on agitation and saliva cortisol in elderly with dementia.
- Trial name
- NCT02271321
- Testing
- White noise
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- Chang Bing Show Chwan Memorial Hospital
Emergence Agitation, Rhinoplasty
Use of Subanesthetic Dose Propofol Before Extubation
This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty.
- Conditions
- Emergence Agitation, Rhinoplasty, Patient Satisfaction
- Trial name
- NCT07276633
- Testing
- Propofol (Sub-Anesthetic Dose)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yuzuncu Yil University
Agitation Associated With, Alzheimer's Disease
Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
To compare the efficacy of flexible dosing of brexpiprazole with placebo in subjects with agitation associated with dementia of the Alzheimer's type
- Conditions
- Agitation Associated With, Alzheimer's Disease, Alzheimer's Type, Mental Disorder
- Trial name
- NCT01922258
- Testing
- Brexpiprazole, OPC-34712
- Where
- 70 sites in United States, Bulgaria and 7 more
- Volunteers
- 270 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Critically Ill, Intensive Care Unit Delirium
Physical Restraints in Intensive Care Unit Patients
The use of physical restraints is common practice in Intensive Care Units (ICU). This medically prescribed procedure requires full attention of medical and paramedical teams for its implementation, monitoring and ending, as a…
- Conditions
- Critically Ill, Intensive Care Unit Delirium, Delirium Confusional State, Agitation,Psychomotor
- Trial name
- ARBORéa (NCT04957238)
- Testing
- ARBORea decision-making tool
- Where
- 19 sites in France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Psychomotor Agitation
The Effect of Dexmedetomidine on Emergence Agitation in Children Undergoing a Surgery Under Desflurane Anesthesia
After genernal anesthesia using sevoflurane or desflurane, the investigators can observe many cases of agiation (over 80%) and despite of no report of long-term complication, agitation is a big issue in PACU for doctors and…
- Trial name
- NCT01578161
- Testing
- Dexmedetomidine, 0.9% Normal Saline
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Alzheimer's Disease
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.
- Trial name
- NCT07011745
- Testing
- Xanomeline/Trospium Chloride Capsule, Xanomeline Enteric Capsule
- Where
- 143 sites in United States, Argentina and 12 more
- Volunteers
- 426 people
- Sponsor
- Bristol-Myers Squibb
Dementia Alzheimers
Interest of the Reborn® Doll as a TO in the Care of Residents With Alzheimer's Disease or a Related Disorder
The primary objective of this study is to evaluate the benefits of the Reborn®doll as an OT for the care of residents with Alzheimer's disease or related disorders, by assessing the frequency of resident agitation.
- Trial name
- PROTMA (NCT06396377)
- Testing
- Reborn doll (Therapeutic object - OT)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Dementia, Agitation
A Naturalistic Two-year Cohort Study of Agitation and Quality of Life in Care Homes
One third of the population, aged over 65, live and will die with dementia. Half of people with dementia experience symptoms of agitation every month.
- Trial name
- MARQUE2 (NCT02216396)
- Where
- United Kingdom
- Volunteers
- 1,734 people
- Sponsor
- University College, London
End Stage Renal Disease, Restless Legs Syndrome
Biotin Deficiency and Restless Legs Syndrome
Restless Leg Syndrome (RLS) is a common neuropathic disorder in patients with end stage renal disease (ESRD). Study Design: Because micronutrient depletion has been associated with RLS in ESRD and because the vitamin biotin is…
- Trial name
- NCT02011191
- Testing
- Biotin Supplementation, Sugar Pill
- Volunteers
- 49 people
- Sponsor
- Heidi Moretti, MS, RD
Schizophrenia
Comparison of Intramuscular Olanzapine and Intramuscular Haloperidol in Patients With Schizophrenia
The purpose of this study is to compare intramuscular Olanzapine and intramuscular Haloperidol in changing of agitation in patients with schizophrenia
- Trial name
- NCT00485901
- Testing
- Olanzapine Hydrochloride, Haloperidol
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Eli Lilly and Company
Multiple Sclerosis, Restless Legs Syndrome
Impact of Acute Leg Cycling at Various Intensities on RLS Severity in Persons With MS
The purpose of this study is to evaluate the impact of acute leg cycling conditions at three different intensities versus a control condition condition on symptoms of restless legs syndrome (RLS) in persons with multiple…
- Trial name
- NCT03849001
- Testing
- Exercise Conditions
- Sponsor
- University of Alabama at Birmingham
Delirium, Ventilators
Helping Older Persons Emerge Stronger
Select Specialty, a national network of more than 100 LTACHs across the United States, has expressed the desire to adopt the ABCDEF bundle as a "standard of care" for its patients.
- Conditions
- Delirium, Ventilators, Pain, Agitation
- Trial name
- HOPES (NCT02863081)
- Testing
- Survey, interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University
Schizophrenia
The Efficacy And Safety Of Intramuscular Ziprasidone For Three Days In Patients With Psychotic Agitation
1. The title of this study is a multi-center,non randomized,open-labeled,intervention study:the efficacy and safety of intramuscular ziprasidone for three days in patients with acute psychotic agitation. 2.
- Trial name
- NCT02935998
- Testing
- Ziprasidone
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yang Fude
Agitation and Aggression in Alzheimer's Disease
A Study of Pimavanserin for the Treatment of Agitation and Aggression in Subjects With Alzheimer's Disease
To evaluate the safety and tolerability of pimavanserin over 52 weeks of treatment in subjects with probable AD who have symptoms of agitation and aggression
- Trial name
- NCT03118947
- Testing
- Pimavanserin
- Where
- 28 sites in United States, Chile and 3 more
- Volunteers
- 79 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Delirium, Epileptics
Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy
To examine the effects of haloperidol, chlorpromazine, valproic acid and placebo, in conjunction with standardized non-pharmacologic interventions, in the first line treatment of agitated delirium in hospitalized patients with…
- Conditions
- Delirium, Epileptics, Neuroleptics
- Trial name
- NCT05431595
- Testing
- Haloperidol, Chlorpromazine, Valproate
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Alzheimer's Disease, Vascular Dementia
Personalized Music Therapy and Agitation in Dementia
Symptoms of agitation include abuse or aggressive behaviour toward self or others, appropriate behaviour performed with inappropriate frequency, or behaviours that are inappropriate according to social standards.
- Trial name
- NCT02147652
- Testing
- Personalized music
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Dementia; Alzheimer, Mixed Type (Etiology)
Non-invasive Brain Stimulation Using Transcranial Direct Current Stimulation for Neuropsychiatric Symptoms of Dementia
Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems.
- Trial name
- NCT03638284
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Centre for Addiction and Mental Health
Agitation in Patients With Dementia of the Alzheimer's Type
Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
This study was conducted to evaluate the efficacy, safety, and tolerability of AVP-786 (deudextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) compared to placebo for the treatment of agitation in participants with…
- Trial name
- NCT04408755
- Testing
- AVP-786
- Where
- 95 sites in United States, Bulgaria and 9 more
- Volunteers
- 184 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.