Clinical trials: Agitated Behaviour
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
A Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects With Alzheimer's Disease Agitation
This study will evaluate the long-term safety and efficacy of AXS-05 in subjects with Alzheimer's disease (AD) agitation.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation, Psychomotor
- Trial name
- ACCORD-2 (NCT04947553)
- Testing
- AXS-05 (dextromethorphan-bupropion)
- Where
- 47 sites in United States, Canada and 1 more
- Volunteers
- 456 people
- Sponsor
- Axsome Therapeutics, Inc.
Entropion
The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery
The investigators evaluate extubation time and recovery profiles in children undergoing entropion surgery.
- Trial name
- NCT02916407
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Inje University
Restless Legs Syndrome, End Stage Renal Disease
Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS)
Uremic etiology Restless legs syndrome (RLS) has been associated with poorer quality of life (QoL) compared to RLS-free counterparts mainly due to sleep deprivation factors.
- Conditions
- Restless Legs Syndrome, End Stage Renal Disease, Hemodialysis, Muscle Cachexia
- Trial name
- HDRLS (NCT00942253)
- Testing
- Dopamine Agonist and Exercise
- Where
- Greece
- Volunteers
- 46 people
- Sponsor
- University of Thessaly
Obstructive Sleep Apnea (OSA), Insomnia
Validating the Use of a Subjectively Reported Sleep Vital Sign
Sleep disorders are commonly under-recognized in the primary care setting and available screening tools are often are limited. The study inestigators hypothesize that the use of a novel subjective sleep vital sign (VS) will…
- Conditions
- Obstructive Sleep Apnea (OSA), Insomnia, Restless Leg Syndrome (RLS), Hypersomnia Type; Sleep Disorder
- Trial name
- SVS (NCT03018912)
- Testing
- Sleep VS
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
ICU Patients Requiring Invasive Mechanical Ventilation
Study of a Strategy to Prevent Oversedation in Intensive Care Patients Under Mechanical Ventilation
The purpose of the present study is to determine whether administration of sedation according to a strategy including a bundle of measures to prevent oversedation is associated with a reduction in mortality of intensive care unit…
- Trial name
- AWARE (NCT01617265)
- Testing
- Clinical Procedure to Prevent Oversedation, Usual sedation practice
- Where
- 43 sites in France
- Volunteers
- 1,180 people
- Sponsor
- French Society for Intensive Care
Psychomotor Agitation
Does Intraoperative Clonidine Reduce Post Operative Agitation in Children?
Clonidine is widely used off-label in children for several indications. Clonidine is used for treatment and/or prevention of postoperative agitation in children anaesthetised with Sevoflurane.
- Trial name
- NCT02361476
- Testing
- Clonidine
- Where
- 3 sites in Denmark
- Volunteers
- 379 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use
Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation
The primary objective of this study is to determine the noninferiority of inhaled loxapine compared to intramuscular haloperidol/lorazepam on agitation reduction at 120 minutes.
- Conditions
- Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use, Lorazepam Causing Adverse Effects in Therapeutic Use, Loxapine Causing Adverse Effects in Therapeutic Use
- Trial name
- loxapine (NCT03110900)
- Testing
- Haloperidol + lorazepam, Loxapine
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Right-To-Left Shunt
Comparing the Safety and Efficacy of ASI-02 to Agitated Saline for Suspected Right-to-left Shunt
This is a phase 3, multicenter, open-label, blinded, crossover trial in which each participant will undergo a randomized sequence of ASI-02 and agitated saline standard of care (SoC) via a saline contrast transthoracic…
- Trial name
- ENHANCE (NCT06938347)
- Testing
- Agitated Saline SoC, ASI-02
- Where
- 8 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Agitated Solutions, Inc.
Alzheimer Disease, Dementia
Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)
The purpose of this study was to determine whether a low dose an opiate pain medication is effective for the treatment of discomfort in patients with advanced dementia.
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Pain
- Trial name
- LDOT (NCT00385684)
- Testing
- hydrocodone/APAP
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Dementia
Efficacy of Doll Therapy in the Dementia in Acute Geriatric Inpatients
Summary. Behavioral and psychological symptoms of dementia (BPSD) represents a huge emotional stress and an important burden for the patients and the caregivers severely reducing their quality of life.
- Trial name
- AGITATE (NCT05691569)
- Testing
- doll therapy
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critically Ill Patients
the Multi-modal Evaluation of Agitation in Critically Ill Patients Based on Remote Video-Ultra-sensitive Detection Wave
The goal of this observational study is to learn about the effectiveness of the multi-modal evaluation for agitation behavior in critically ill patients based on remote video-Ultra-sensitive detection wave.
- Trial name
- NCT06543602
- Testing
- multi-model monitoring and alert
- Where
- 2 sites in China
- Volunteers
- 580 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Agitation
Quality Improving Program on Agitation in the Surgical Intensive Care Unit
Agitation in the intensive care unit can have multiple consequences. The investigators hypothesize that agitation and its consequences can be reduced by the introduction of a reminder aiming at guiding the management of…
- Trial name
- NCT02199262
- Testing
- music intervention, reflexology, reminder
- Where
- Switzerland
- Volunteers
- 1,107 people
- Sponsor
- University Hospital, Geneva
Anxiety, Agitation
Family Videos and Virtual Reality in Intensive Care Patients
This randomized controlled trial was conducted to evaluate the effects of family videos and virtual reality-based nature videos on anxiety, agitation, pain, and vital signs in adult intensive care unit patients.
- Conditions
- Anxiety, Agitation, Pain, Physiological Parameters
- Trial name
- NCT07794696
- Testing
- Family Video.Participants watched a five-minute video prepared by their family members twice daily on the second and third days of intensive care.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Sennur Kula Şahin
Schizophrenia
Study of Alternate Formulation of Aripiprazole in Agitated Patients With Schizophrenic Disorders
Study to learn if the alternate formulation is effective in agitated schizophrenic patients
- Trial name
- NCT00036127
- Testing
- aripiprazole
- Where
- 16 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Delivery of Health Care, Education, Medical
Effects of the Humanitude® Care Methodology on Health Professionals' Perception
Healthcare professionals providing care for institutionalized older patients must deal with agitated behavior daily. Such behavior alters the patient's quality of life and generates stress for the caregiver.
- Conditions
- Delivery of Health Care, Education, Medical, Caregiver
- Trial name
- Humanitude (NCT06450249)
- Testing
- Humanitude® Care Methodology (HCM) training sessions, Self-administered questionnaire
- Where
- 2 sites in France
- Volunteers
- 455 people
- Sponsor
- Lille Catholic University
Alzheimer Disease, Agitation,Psychomotor
Clinical Trial on Agitation in Alzheimer's Dementia
The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from…
- Conditions
- Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
- Trial name
- CALMA (NCT05543681)
- Testing
- IGC-AD1-Active
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 164 people
- Sponsor
- IGC Pharma, LLC
Behavioral Monitoring in ICU, Prediction of Accidental Events Using AI-Assisted Video Analysis
Exploring the Use of AI-Assisted Video Monitoring to Predict Accidental Events in ICU Patients
This study aims to improve the safety and care of patients in the Intensive Care Unit (ICU) by using artificial intelligence (AI) to analyze video monitoring.
- Conditions
- Behavioral Monitoring in ICU, Prediction of Accidental Events Using AI-Assisted Video Analysis, ICU Patient Safety and Early Warning System
- Trial name
- AIME-ICU (NCT07307521)
- Testing
- AI-Assisted Video Monitoring
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium on Emergence, Elderly
Music Timing for Emergence Delirium in Elderly
Emergence delirium (ED) after general anesthesia prolongs recovery, increases complications, and adds to nursing workload in elderly patients.
- Conditions
- Delirium on Emergence, Elderly, Satisfaction, Patient
- Trial name
- NCT06970249
- Testing
- Music intervention
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Wonkwang University Hospital
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Dementia
Treating Behavioral Disturbances in Individuals With Dementia
This study will compare the safety and effectiveness two medications, citalopram (Celexa®) and risperidone (Risperdal®).
- Trial name
- NCT00073658
- Testing
- Citalopram, Risperidone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Pittsburgh