Clinical trials: Agranulocytosis
Neoplasms, Neutropenia
Profiling Neutrophil Counts in Patients on Chemotherapy
The purpose of this trial is to observe the changes in white cell counts in patients with cancer during chemotherapy and to determine if changes in the white cell count in the early days during chemotherapy can be used as a…
- Conditions
- Neoplasms, Neutropenia, Febrile Neutropenia
- Trial name
- NCT02806557
- Testing
- Home finger-prick capillary blood count monitoring
- Volunteers
- 200 people
- Sponsor
- University of Leeds
Safety Issues
Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever
This is a randomized study to evaluate the safety and feasibility of early de-escalation of empirical antibiotics treatment in neutropenic fever patients undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT04270786
- Testing
- Early de-escalation, Standard
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cytomegalovirus Retinitis, HIV Infections
Phase III Ganciclovir +/- rGM-CSF for AIDS-Related CMV Retinitis
To determine whether co-administration of sargramostim (granulocyte-macrophage colony-stimulating factor; GM-CSF) improves tolerance to ganciclovir in patients previously intolerant because of neutropenia defined as an absolute…
- Trial name
- NCT00002070
- Testing
- Sargramostim, Ganciclovir
- Where
- 14 sites in United States
- Sponsor
- Schering-Plough
Colorectal Cancer, Diarrhea
Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy
RATIONALE: Genetic testing may help predict how patients will respond to chemotherapy drugs and may help doctors plan more effective treatment with fewer side effects.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT00048971
- Testing
- mutation analysis, polymorphic microsatellite marker analysis
- Where
- 84 sites in United States, Canada and 1 more
- Volunteers
- 308 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Multiple Myeloma, Myelodysplastic Syndromes
A Study of Special Use Results Surveillance of Revlimid 5mg Capsules
To understand the safety and efficacy of Revlimid® 5 mg Capsules (hereinafter referred to as Revlimid) in all patients who are treated with it under the actual condition of use pursuant to the conditions of approval. 1.
- Trial name
- NCT02921802
- Where
- Japan
- Volunteers
- 4,626 people
- Sponsor
- Celgene
Cancer
A Study Comparing Pegylated Filgrastim and Filgrastim in Support for Chemotherapy
Neutropenia is one of the most frequent adverse effects of chemotherapy, and the main factor to limit the dosage and delay the schedule of chemotherapy.
- Trial name
- NCT01285219
- Testing
- pegylated filgrastim and filgrastim, filgrastim and pegylated filgrastim
- Volunteers
- 337 people
- Sponsor
- Chinese Academy of Medical Sciences
Febrile Neutropenia, Drug-Induced
Predictive Value of ProCalcitonin for the Detection of Bacteraemia in Patients Presenting to the Emergency Department for Low Risk Chemo-induced Febrile Neutropenia
CALIF study is a monocentric observational study which aim is to analyse the value of adding procalcitonin (PCT, a pre-hormon increased in bacterial infection and septicaemia) in the management of chemo-induced febrile…
- Trial name
- CALIF (NCT03182465)
- Testing
- Value of ProCalcitonin
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Schizophrenia, Agranulocytosis
Clozapine Hematological Monitoring Regulatory Compliance Assessment in Psychiatry
Clozapine is a drug that requires regular and diligent hematological monitoring throughout its use. This follow-up is, in France, framed by a compulsory paper format of the blood count follow-up notebook for each patient.
- Trial name
- NCT06610500
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Lung Cancer, Small-cell Lung Cancer
Study of Trilaciclib and Lurbinectidin
Lung cancer is by far the leading cause of cancer death among both men and women worldwide and the second most common cancer in terms of new cases. Small cell lung cancer (SCLC) is the deadliest form of lung cancer.
- Trial name
- NCT05578326
- Testing
- Trilaciclib, Lurbinectedin
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neutropenia, Febrile, Leukemia
Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever
Empirical antibiotic therapy has been known to reduce the mortality and morbidity rate in neutropenic fever. Until now, ceftazidime was the first line choice of neutropenic fever.
- Conditions
- Neutropenia, Febrile, Leukemia, Pediatric Cancer, Antibiotic Reaction
- Trial name
- NCT04187755
- Testing
- Ceftazidime Injection, Cefepime Injection
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Indonesia
Leukemia, Neutropenia
Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00002658
- Testing
- filgrastim, amsacrine, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Medical Research Council
Febrile Neutropenia, Non-myeloid Malignancy
An Analysis to Estimate Febrile Neutropenia (FN) in Patients Receiving Udenyca
This is a multicenter, prospective, observational cohort registry in subjects receiving myelosuppressive chemotherapy for a non-myeloid malignancy who are considered to be at high risk for developing febrile neutropenia (FN).
- Trial name
- POEM (NCT04662892)
- Testing
- Pegfilgrastim-Cbqv
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Coherus Oncology, Inc.
Neutropenia, Febrile, Pediatric Cancer
Early Termination of Empirical Antibiotics in Febrile Neutropenia in Children With Cancer
The study is a nationwide, multicenter, open label, randomized controlled trial. A target population of 220 children in treatment for cancer with neutropenic fever and a neutrophil count below 0.5 × 10⁹ cells/L with expected…
- Trial name
- NCT04637464
- Testing
- Early termination of empirical antibiotics
- Where
- 3 sites in Denmark
- Volunteers
- 93 people
- Sponsor
- Kjeld Schmiegelow
Neutropenic Fever
Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection
This is a comparative study for adult participants with cancer who are suspected to have neutropenic fever (or fever with low neutrophil count) in emergency department.
- Trial name
- FRANCiS-NF (NCT05393505)
- Testing
- Meropenem Injection, Levofloxacin, Amoxicillin Clavulanate
- Where
- Hong Kong
- Volunteers
- 344 people
- Sponsor
- The University of Hong Kong
Neutropenia
Maintaining a Higher Level of Haemoglobin: Effect on the White Cells After Bone Marrow Transplantation in Children.
The purpose of this study is to determine if maintaining a high hemoglobin level in children that underwent bone marrow transplant will accelerate the neutrophil recovery.
- Trial name
- NCT00937053
- Testing
- Transfusion level 120 g/dL, Transfusion level 70 g/dL, Platelet transfusion
- Where
- 5 sites in Canada
- Volunteers
- 6 people
- Sponsor
- St. Justine's Hospital
Infection, Febrile Neutropenia
Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients
The aim of the study is to evaluate the efficacy and safety of Teicoplanin versus Vancomycin as part of the initial antibiotic regimen in the therapy of patients with fever and neutropenia .
- Trial name
- NCT00454272
- Testing
- Teicoplanin, Vancomycin
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Sanofi
Febrile Neutropenia
Amoxicillin-clavulanate Alone or in Combination With Ciprofloxacin in Low-Risk Febrile Neutropenic Adult Patients: A Prospective, Double-blind, Randomized, Non-Inferiority Multicenter, Phase III Clinical Trial.
In low risk neutropenic fever in cancer, standard of care is the association of amoxicillin clavulanate and ciprofloxacin. But in this population, the rate of fever related to infection is very low, leading to a overtreatment of…
- Trial name
- ACACIA (NCT04698057)
- Testing
- Amoxicillin Clavulanate, Ciprofloxacin
- Sponsor
- Poitiers University Hospital
Hematological Malignancies, Cancer
Cologne Cohort of Neutropenic Patients (CoCoNut)
The Cologne Cohort of Neutropenic Patients (CoCoNut) is a non-interventional cohort study assessing risk factors, interventions, and outcome of immunosuppressed patients with or without opportunistic infections.
- Conditions
- Hematological Malignancies, Cancer, Chemotherapy, Neutropenia
- Trial name
- CoCoNut (NCT01821456)
- Testing
- Antiinfectives
- Where
- Germany
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Neutropenic Fever
Assessment of sTREM-1 as a Diagnostic Marker in Patients With Neutropenic Fever
The soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) was an established biomarker useful for infection in non-neutropenic patients. In this study, we tested sTREM-1 in the patients with neutropenic fever.
- Trial name
- NCT01034059
- Volunteers
- 75 people
- Sponsor
- National Taiwan University Hospital
Non-Hodgkin's Lymphoma
Treatment for Subjects With Non-Hodgkin's Lymphoma
This multicenter, open-label, randomized, parallel study was designed to evaluate whether a single fixed-dose subcutaneous (SC) administration of pegfilgrastim or daily administration of Filgrastim for absolute neutrophil count…
- Trial name
- NCT00117897
- Testing
- pegfilgrastim, Filgrastim
- Sponsor
- Amgen