Clinical trials: Aids
HIV
Dyadic-Based Diagnosis, Care, and Prevention for HIV Discordant Couples in Tanzania
This is a prospective observational study of couples in Kisarawe, Tanzania who will be provided an intervention that offers: (1) HIV self-testing kits and pre-test counseling provided at the household, (2) linkage to a counseling…
- Trial name
- DDCP (NCT03098693)
- Testing
- HIV Self-Testing, Immediate Access to ART for HIV infected couple members, Access to PrEP for HIV uninfected couple members
- Where
- Tanzania
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Infection, Human Immunodeficiency Virus
Dolutegravir Renal Impairment Study
Dolutegravir (DTG, GSK1349572) is an integrase inhibitor being developed for the treatment of human immunodeficiency virus (HIV)-1 infection by GlaxoSmithKline (GSK) on behalf of Shionogi-ViiV Healthcare LLC.
- Trial name
- NCT01353716
- Testing
- Dolutegravir 50 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Pre-Exposure Prophylaxis
Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers
The study will be a randomized, open-label, cross-over clinical pharmacokinetic trial to investigate a strategy for probenecid "boosting" in the setting of tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for HIV…
- Trial name
- NCT03202511
- Testing
- Probenecid Oral Tablet, Tenofovir disoproxil fumarate/Emtricitabine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Methamphetamine Abuse, HIV/AIDS
FASTLANE II: Reducing Sex, Drug, and Mental Health Risk
The study uses a repeated measures, single group pretest-posttest design methodology to examine the feasibility, acceptability, and preliminary effectiveness of the FASTLANE II intervention aimed at decreasing risky sex behaviors…
- Conditions
- Methamphetamine Abuse, HIV/AIDS, Depression, Sex, Unsafe
- Trial name
- FLII (NCT04109014)
- Testing
- FASTLANE II
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Male Circumcision, HIV Prevention
The Shang Ring: A Novel Male Circumcision Device for HIV Prevention
The purpose of this study is to evaluate the Shang Ring, a novel Chinese device for voluntary medical male circumcision, in order to improve the provision of male circumcision services for HIV prevention in Africa.
- Conditions
- Male Circumcision, HIV Prevention, HIV Infections
- Trial name
- ShangRing (NCT00993811)
- Testing
- Shang Ring circumcision
- Where
- Kenya
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Diarrhoea
Causes of Rotavirus Vaccine Failure in Zambian Children
Zambia recently introduced routine infant immunization against rotavirus - the most important cause of severe gastroenteritis and diarrhoea mortality in children.
- Trial name
- NCT01886833
- Where
- Zambia
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
HIV Testing and Counseling
Community-based Delivery of Integrated Family Planning/HIV Testing and Counseling Services in Uganda
The purpose of this study is to evaluate the feasibility and acceptability of adding HIV testing and counseling (HTC) services to the family planning (FP) services provided by community health workers in Uganda.
- Trial name
- NCT02244398
- Testing
- FP and HTC services, FP services
- Where
- Uganda
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- FHI 360
Healthy, Pharmacokinetics
Influence of Drug Transporter Expression on the Pharmacokinetics of the HIV Protease Inhibitor Kaletra
The aim of this study is to determine the pharmacokinetics of Kaletra™ (HIV protease inhibitors lopinavir and ritonavir) in different body compartments and to assess the role of four different drug transporters (MDR, MRP1, MRP2…
- Trial name
- NCT00176033
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
HIV Infections, Acquired Immunodeficiency Syndrome
An Expanded Safety Study of Dapivirine Gel 4789 in Africa
The purpose of this study is to determine whether dapivirine gel 4789 is safe for daily use by healthy women in South Africa.
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Healthy
- Trial name
- NCT00917904
- Testing
- dapivirine
- Where
- 3 sites in South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Human Immunodeficiency Viruses
Evaluation of Diagnostic HIV Ag/Ab Combo Assay
To test blood specimens using a new investigational test that detects antigen and antibody to human immunodeficiency virus (HIV).
- Trial name
- NCT00933933
- Testing
- ARCHITECT HIV Ag/Ab Combo
- Where
- 13 sites in United States
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Abbott Diagnostics Division
Health Behavior, Risky, Health Knowledge, Attitudes, Practice
Sistas Informing Sistas on Topics About AIDS and Prevention (SISTA-P)
In this project, the investigators will provide a new HIV prevention training and empowerment sessions to Black women in Washington D.C., Atlanta and New Orleans, who are at high risk for getting HIV.
- Conditions
- Health Behavior, Risky, Health Knowledge, Attitudes, Practice, Health-Related Behavior
- Trial name
- SISTA-P (NCT06307028)
- Testing
- SISTA-P Intervention
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
HIV
SCOPE: Strategies to Combine PrEP With Prevention Efforts
This pilot, open-label, prospective study will determine the feasibility of integrating pre-exposure prophylaxis (PrEP) into existing HIV prevention programs for female sex workers and if women who are enrolled in those programs…
- Trial name
- SCOPE (NCT01832571)
- Testing
- Once daily Truvada®
- Where
- 2 sites in Kenya
- Volunteers
- healthy volunteers welcome
- Sponsor
- FHI 360
Anal Intraepithelial Neoplasia
Biomarkers to Detect Anal Intraepithelial Neoplasia in Thai Men Who Have Sex With Men
The goals of this application are to assess the usefulness of biomarkers, including p16 proteins, minichromosome maintenance (MCM) proteins, high-risk human papillomavirus (HPV) types, and E6 and E7 mRNA/oncoproteins, as adjunct…
- Trial name
- NCT01637298
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
HIV Infections, HIV Seronegativity
Carotid Artery Thickness in HIV Infected and Uninfected Adults
The intima-media thickness (IMT) test is a low cost, non-invasive way to measure the thickness of the carotid artery (the large artery in the neck).
- Conditions
- HIV Infections, HIV Seronegativity, Atherosclerosis
- Trial name
- NCT00007319
- Where
- 10 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Seropositivity, Dyslipidemias
COPANA - A09 PCSK 9 Substudy: Impact of Protease Inhibitors on PCSK9 Levels in Naive HIV-Infected Patients
Evaluation of the impact of initiation of protease inhibitor/ritonavir on PCSK9 levels in HIV-infected antiretroviral-naïve patients from the ANRS C09 COPANA cohort.
- Conditions
- HIV Seropositivity, Dyslipidemias, PCSK9
- Trial name
- COPANA (NCT03139630)
- Where
- France
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Franck Boccara
HIV Testing
Increasing HIV Testing in Urban Emergency Departments Via Mobile Technology
Because people with undiagnosed HIV will not receive treatment and may unknowingly infect others, the investigators propose a mobile computer-based video intervention to increase HIV test rates in high volume urban hospital…
- Trial name
- NCT02154802
- Testing
- video: community member, video: physician, video: choice of video
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Development and Research Institutes, Inc.
HIV Infections
Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring
The purpose of this study is to assess the pharmacokinetics of the combination dapivirine and maraviroc vaginal ring and determine whether it is safe when used continuously for 28 days by healthy women in the United States.
- Trial name
- NCT01363037
- Testing
- Dapivirine Vaginal Ring, Maraviroc Vaginal Ring, Dapivirine-Maraviroc Vaginal Ring
- Where
- 3 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Hiv, Sexually Transmitted Infections (Not HIV or Hepatitis)
Improving Perinatal Outcomes Among Kenyan Pregnant Women With an Integrated STI Testing Model
The investigators will conduct a 3-arm individual-level RCT in Kisumu and Siaya, Kenya to compare perinatal outcomes associated with 3 models of STI testing and management in antenatal care.
- Trial name
- PrIMI (NCT06203951)
- Testing
- Xpert® CT/NG and TV testing
- Where
- 8 sites in Kenya
- Volunteers
- 3,132 people, healthy volunteers welcome
- Sponsor
- University of Washington
Human Immunodeficiency Virus Positive or Negative
Effects of Endocrine Health on Mental Performance of Men and Women Using Drugs
The purpose of this study is to understand the effects of decreased functioning of the testes or ovaries on mental performance in males and females using illicit drugs excluding marijuana.
- Trial name
- NCT00245531
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tuberculosis (TB), Tuberculosis Infection, Latent
Screening With Portable X-rays for Rapid Recognition of TB
SPOT-TB (Screening with Portable X-rays for rapid recOgniTion of TB) is a prospective study evaluating a community-based tuberculosis (TB) screening strategy for migrant populations in New York City.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, HIV (Human Immunodeficiency Virus)
- Trial name
- SPOT-TB (NCT07737275)
- Testing
- Mobile chest radiography for tuberculosis screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University