Clinical trials: Airway Disease
Bronchial Asthma, Status Asthmaticus
NiPPV in the Treatment of Acute Asthma Exacerbations
Study Summary: Title: A Randomized Controlled Trial of Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations Principal Investigator: Thomas J.
- Trial name
- NCT03219736
- Testing
- Standard of Care therapies, NiPPV Therapy, Routine Respiratory Care
- Where
- United States
- Sponsor
- Arkansas Children's Hospital Research Institute
Neonatal Resuscitation
Non-inflatable Supraglottic Airway (NI-SGA) vs. Face Mask (FM) as a Primary Interface Device for Neonatal Resuscitation
Prospective, randomized controlled trial to be performed at one center, of term and late preterm infants requiring resuscitation. Prenatal consent will be obtained.
- Trial name
- NCT02629887
- Testing
- Non-inflatable supraglottic airway, Face Mask, T-Piece Resuscitator
- Where
- United States
- Sponsor
- University of Oklahoma
Asthma
Determining the Optimal Adenosine Provocation Test
Asthma is a frequently occurring inflammatory lung disease that affects the whole bronchial tree including the small airways (<2mm).
- Trial name
- impact (NCT01610921)
- Testing
- Bronchial provocation test
- Where
- 2 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Airway Obstruction, Pain
Dental Isolation Systems Among Pediatric Patients With Different Airway Patency
This randomized clinical trial will aim to evaluate the effect of DryShield isolation (DSI) and Rubber Dam isolation (RDI) systems on arterial oxygen saturation (SpO2), heart rate (HR), blood pressure (BP), behavior, subjective…
- Conditions
- Airway Obstruction, Pain, Behavior
- Trial name
- NCT06128811
- Testing
- Rubber Dam Isolation, DryShieled isolation, fissure sealant
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Bronchiolitis
Using Nasal Broadband Glasses in the Initial Management of Severe Bronchiolitis in Infants Admitted in ICU
The aim of this study is to evaluate the use of nasal broadband glasses HFNC (High Flow Nasal Cannula) in the initial management of severe bronchiolitis in infants admitted in ICU.
- Trial name
- HFNC (NCT02791711)
- Testing
- High Flow Nasal Cannula
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- Fondation Lenval
Asthma, Eosinophilic Asthma
Intense Airway Eosinophilia in Asthma
In asthma, the type and importance of the inflammatory response in the airways has allows identification of different phenotypes.
- Trial name
- NCT03696914
- Where
- Canada
- Volunteers
- 918 people
- Sponsor
- Laval University
Asthma
Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma
The purpose of this study is to investigate the effect on airway inflammation and JAK1-associated signalling pathways of AZD4604 compared with placebo in participants with moderate-to-severe asthma.
- Trial name
- ARTEMISIA (NCT06435273)
- Testing
- AZD4604
- Where
- 18 sites in Canada, Denmark and 3 more
- Volunteers
- 36 people
- Sponsor
- AstraZeneca
COPD
COPD Originates in Polluted Air
The investigators are investigating the effects of traffic-related diesel exhaust on lung function and the immune system in those at risk for COPD.
- Trial name
- COPA (NCT02236039)
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Airway Disorder
Optimizing High Flow Nasal Cannula Oxygenation in Pediatric Airway Procedures
The purpose of this study is to investigate which flow rate (higher versus lower) is most effective at increasing apneic time and preventing greater than 5% drop in desaturation, as well as assessing transcutaneous carbon dioxide…
- Trial name
- NCT06947902
- Testing
- High flow, Low Flow
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obstructive Sleep Apnea
Obstructive Sleep Apnea Airway Evaluation
Current practice guidelines recommend obstructive sleep apnea (OSA) patients to stay in the post anesthetic care unit (PACU) until the risk of respiratory depression has subsided.
- Trial name
- NCT03361553
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Asthma, Small Airway Disease
The Prevalence Of Small Airways Dysfunction In Asthma Patients And The Impact On The Asthma Control
Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden.
- Trial name
- NCT04375995
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Pediatric Bronchiolitis Obliterans
Treatment of Pediatric Bronchiolitis Obliterans by Airway Basal Stem Cells
Bronchiolitis obliterans (BO) is a chronic lung disease which was initiated with injury of the bronchiolar epithelium and resulted in nonuniform luminal obliteration or narrowing.
- Trial name
- NCT07239895
- Testing
- Airway Basal Stem Cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Regend Therapeutics
Recent Acute Myocardial Infarction
Impact of the Obstructive Sleep Apnea Syndrome (OSAS) on the Ventricular Remodeling After Acute Myocardial Infarction
Coronary artery disease is a common and serious disease, the leading cause of death worldwide. Obstructive sleep apnea syndrome (OSAS) is common and often under-diagnosed in coronary artery disease where it could be involved in…
- Trial name
- SAS-IDM (NCT02439294)
- Testing
- Without Obstructive Sleep Apnea (syndrome), Mild or moderate Obstructive Sleep Apnea (syndrome), Severe Obstructive Sleep Apnea (syndrome)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Montpellier
Lung Cancer
Stereotactic Body Radiotherapy and Radiofrequency Ablation for Lung Tumors Near Central Airways
The purpose of this study is to demonstrate that combined stereotactic body radiotherapy and radiofrequency ablation is safe for patients with lung tumors near central airways.
- Trial name
- NCT01051037
- Testing
- Stereotactic Body Radiation, Radiofrequency Ablation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Obstructive Sleep Apnea
Effect of Nasal Continuous Positive Airway Pressure (CPAP) Blood Pressure and Vascular Endothelial Growth Factor in Obstructive Sleep Apnea Syndrome
Sleep-disordered breathing (SDB) briefly means cessation of breathing during sleep at least 5 times per hour. SDB is a common disorder affecting 9 to 24% of the middle-aged and overall 4% of the middle-aged male population…
- Trial name
- NCT00300872
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Asthma, COPD
Causes, Characteristics and Mechanisms of Infective Exacerbations in Subjects With Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Diseases of the airways (bronchi) of the lungs include asthma and chronic obstructive pulmonary disease (COPD), which are leading causes of reduced quality of life, loss of work, hospital admissions and deaths and result in a…
- Trial name
- NCT00512954
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Chronic Airway Disease and Multimorbidity Cohort
Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Bronchiectasis
- Trial name
- CAM Cohort (NCT06798077)
- Where
- 9 sites in China
- Volunteers
- 2,000 people
- Sponsor
- China-Japan Friendship Hospital
Sleep Apnea, Obstructive
Prescision Medicine in Obstructive Sleep Apnea, Cardiovascular and Cerebrovascular Disease: AI Electrocardiogram Patch Does it All
Obstructive Sleep apnea(OSA) is a disease with multiple causes, and treatments are very diverse. Patients and doctors have a lot of choices.
- Trial name
- NCT05566860
- Testing
- Positional Therapy, Intraoral Negative Pressure Therapy, Oral Appliances
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Respiratory Insufficiency
Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation
The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.
- Trial name
- NCT00453726
- Testing
- Non invasive mechanical ventilation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale S. Giovanni Bosco
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD)
Human and animal studies have shown that inhaled corticosteroids (ICS) decrease airway blood flow . This effect is immediate (within 30 minutes), transient (lasting 90 minutes), and in animal studies independent of gene…
- Trial name
- NCT00202189
- Testing
- Budesonide
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Queen's University
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