Clinical trials: Airway Disease
Asthma, Bronchial Hyperreactivity
Early Antiinflammatory Treatment of Asthma
The inflammatory process that leads to the development of asthma may be present before the onset of asthma symptoms and cause a certain degree of airway hyperresponsiveness.
- Trial name
- EATA (NCT00567463)
- Testing
- Fluticasone
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Laval University
Airway Obstruction
Maxillary Expansion Effects in Children With Upper Airway Obstruction
The most frequent causes of mouth breathers are the adenotonsillar hypertrophy. Adenotonsillectomy is the main choice for the elimination of the obstruction.
- Trial name
- NCT03004300
- Testing
- Rapid maxillary expansion, Adenotonsillectomy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Lung Diseases
Breath Analysis by Ion Mobility Spectrometry
Recognition of disease specific clusters of volatile organic compounds in patients with different lung diseases, using breath analysis with ion mobility spectrometry.
- Trial name
- NCT00632307
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lung Clinic Hemer
COPD Exacerbation, COPD
Impulse Oscillometry in COPD Exacerbation
This study aimed to evaluate small airway function during ECOPD and recovery periods using IOS. In this prospective single-center study, patients with ECOPD underwent evaluation of their pulmonary functions using IOS and…
- Trial name
- NCT07185581
- Testing
- Impulse Oscillometry
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Deniz Bilici
Nasal Obstruction
Correlation of the Objective and Subjective Measures of the Nasal Obstruction Before and After Surgery of the Nasal Septum
Nasal obstruction is a very subjective sensation but it's also a frequent reason of consultation. Two specific questionnaire NOSE and RhinoQOL were validated; but rhinomanometry value is still a question to debate.
- Trial name
- NCT03331107
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Acute Lung Injury
Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial
The main hypothesis are: 1. Passive and Active-Passive airway conditioning devices reduce the incidence of ventilator associated pneumonia 2.
- Trial name
- AirconVAP (NCT01150864)
- Testing
- Airway Conditioning
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Università degli Studi dell'Insubria
Heart Failure, Obstructive Sleep Apnea
Sleep Apnea in Heart Failure With Preserved Ejection Fraction
This is a prospective interventional study to better understand i) the prevalence of Obstructive Sleep Apnea (OSA) in Heart Failure with preserved Ejection Fraction (HFpEF), ii) its hemodynamic correlates, and iii) the impact of…
- Trial name
- NCT05008432
- Testing
- Home sleep apnea testing
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Pulmonary Disease, Chronic Obstructive
Postmarketing Surveillance Study of Atrovent® Inhalets in Chronic Obstructive Airways Disease
To obtain further information on the tolerability of Atrovent® inhalets in the treatment of Chronic Obstructive Airways Disease under conditions of daily practice
- Trial name
- NCT02238132
- Testing
- ATROVENT® inhalets
- Volunteers
- 374 people
- Sponsor
- Boehringer Ingelheim
Asthma, Rhinitis
Study of Asthma and Nasal Steroids
The trial will study the effectiveness of nasal steroids for the treatment of chronic rhinitis and/or sinusitis on asthma control.
- Conditions
- Asthma, Rhinitis, Sinusitis
- Trial name
- STAN (NCT01118312)
- Testing
- Mometasone Furoate monohydrate
- Where
- 19 sites in United States
- Volunteers
- 388 people
- Sponsor
- JHSPH Center for Clinical Trials
Pneumonia, Pleural Effusion
Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation
The objective of this study is to assess whether there is a difference between a care protocol with the use of incentive spirometry (Voldyne ®) and another with the application of NIV (non invasive ventilation with single-level…
- Conditions
- Pneumonia, Pleural Effusion, Atelectasis
- Trial name
- NCT01416519
- Testing
- Continuous Positive Airway Pressure (CPAP) facial mask, Assisted deep inspiration technique
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Santa Casa de Votuporanga
Endotracheal Intubation
ED Airway Management in the Netherlands.
Airway management is one of the resuscitative procedures patients may undergo in the Emergency Department (ED). While this is a high risk procedure, to date there is no data available on airway management practices, success or…
- Trial name
- DEAR (NCT06558630)
- Testing
- Endotracheal intubation
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Frisius Medisch Centrum
Lung Cancer, Thoracic Cancer
Investigating Radiation-Induced Injury to Airways and Pulmonary Vasculature in Lung Stereotactic Ablative Body Radiotherapy (SAbR)
We will conduct a prospective clinical study involving up to 40 non-Small Cell Lung Cancer (nSCLC) patients to determine dose thresholds for central and peripheral BSS elements.
- Trial name
- NCT05459311
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Bronchiectasis with Acute Exacerbation
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and…
- Trial name
- NCT06726356
- Testing
- Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Impaired Glucose Tolerance, Obstructive Sleep Apnea
Effects of Treatment of Sleep Apnea on Metabolic Syndrome
The investigators performed a randomized, cross-over controlled clinical trial comparing 8 weeks of Continuous Positive Airway Pressure (CPAP) to 8 weeks of sham-CPAP in patients with moderate to severe Sleep Disordered Breathing…
- Trial name
- NCT01385995
- Testing
- Continuous Positive Airway Pressure (CPAP) (Philips-Respironics RemStar Pro® CPAP)
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
COPD
The Effect of High Dose N-acetylcysteine on Airtrapping and Airway Resistance in Chronic Obstructive Pulmonary Disease (COPD) Patients
This study is to investigate the add-on effect of high dose NAC (600mg tablet twice daily) on reduction of airtrapping and airway resistance in stable COPD patients as well as to study it's effect in reducing exacerbation…
- Trial name
- NCT01136239
- Testing
- N-acetycysteine (600mg twice daily)
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Kwong Wah Hospital
Difficult Intubation, Airway Disease
STOP-Bang Questionnaire: A Predictor of Obstructive Sleep Apnea and Difficult Mask/Intubation?
Difficult airway management remains the leading cause of anaesthesia-related morbidity and mortality. Obstructive sleep apnea syndrome (OSAS) is a warning sign of difficult airway management.
- Trial name
- NCT06247631
- Testing
- STOP BANG
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Obstructive Sleep Apnea Syndrome
Non-automatic Control of Gait and Posture in Obstructive Sleep Apnea Syndrome (CIH-Gait)
The purpose of this randomised controlled study is to determine the impact of continuous positive airway pressure (CPAP) versus sub-therapeutic CPAP (placebo) on the control of gait upon severe sleep apnea patients, based on…
- Trial name
- CIH-Gait (NCT02345694)
- Testing
- Effective CPAP, Sub-therapeutic CPAP
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea, Ischaemic Heart Desease
Impact of Continuous Positive Airway Pressure (CPAP) Therapy on Outcomes in Patients Undergoing Coronary Revascularization
Investigators assume that continuous positive airway pressure (CPAP) therapy can reduce the mortality, stroke rate and secondary coronary surgery in CAD with obstructive sleep apnea (OSA) patients after percutaneous coronary…
- Trial name
- NCT02080156
- Testing
- CPAP
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Anzhen Hospital
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