Clinical trials: Airway Disease
Diastolic Heart Failure
Positive Airway Pressure Therapy Study in Sleep Apnea and Diastolic Heart Failure
This is a multicenter, prospective, randomized clinical trial (pilot study). 20 participants with diastolic heart failure will be assigned to ventilation therapy (AutoSet CS ™ ASV device; therapy group).
- Trial name
- ParadiseHF (NCT02254382)
- Testing
- Adaptive servo ventilation (ASV)
- Where
- 2 sites in Germany
- Volunteers
- 2 people
- Sponsor
- ResMed
Airway Disease, Fistula Bronchial
Airway Stent Modified With 3D Printing for Gastro-respiratory Fistula Involving Carina and Distal Bronchi
In this study, the investigators used the covered metallic segmented airway stent modified with 3D printing to treat gastro-respiratory fistula involving carina and distal bronchi and aimed to determine the feasibility, efficacy…
- Conditions
- Airway Disease, Fistula Bronchial, Fistula, Gastric
- Trial name
- NCT03890523
- Testing
- Airway stent implantation
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
Hyperactivity, Chronic Rhinosinusitis (Diagnosis)
Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Chronic Rhinosinusitis (Diagnosis), Chronic Rhinitis, Upper Respiratory Disease
- Trial name
- NCT03893227
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bronchiolitis Acute
Bronchiolitis Clearance Airways With Seaserum
The objective of this study is to show that the use of electrodialyzed seawater reduces the duration (in days) of symptoms in acute infant bronchiolitis compared with the use of saline solution in infants aged 1 month to less…
- Trial name
- B-CLASS (NCT06177197)
- Testing
- Physiomer, Saline solution
- Where
- 8 sites in France
- Volunteers
- 458 people
- Sponsor
- University Hospital, Brest
Primary Ciliary Dyskinesia
Respiratory Physiotherapy Performed by Simeox In Patients With Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is characterized by impaired airway clearance and mucus stagnation. This results in recurrent upper and lower respiratory tract infections often leading to chronic inflammation and, if not treated…
- Trial name
- NCT04793724
- Testing
- Simeox, PARI O PEP
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital, Motol
Asthma
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)
This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit.
- Trial name
- SEARCH (NCT02791542)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Gastrointestinal Endoscopy
Application of New Oropharyngeal Airway Management in Obese Patients Undergoing Painless Gastroenteroscopy
Painless endoscopy is a popular method of endoscopic diagnosis and treatment. Propofol combined with fentanyl general intravenous anesthesia has been widely used in painless endoscopic diagnosis and treatment.However, the…
- Conditions
- Obesity, Gastrointestinal Endoscopy, Airway Management
- Trial name
- NCT06590922
- Testing
- Group using new oropharyngeal airway (experimental group), The conventional endoscopic biting group (control group)
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis
Study design: Parallel group, placebo-controlled, dose-escalation each 2 months for 12 months. Dose based on percent (%) of calculated caloric intake.
- Trial name
- A-TC7 (NCT04513002)
- Testing
- Triheptanoin
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- The University of Queensland
Sleep Apnea, Obstructive
Biological and Cognitive Marker of Neurodegeneration in Obstructive Sleep Apnea Patients
The goal of this observational study is to investigate biomarkers and neurocognitive markers of neurodegenerative processes in obstructive sleep apnea patients.
- Trial name
- NCT06167369
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Technische Universität Dresden
Tracheostomy Decannulation, Acquired Brain Injury
Comparison of the Decannulation Protocol With Suctioning and Capping in Severe Acquired Brain Injury Patients
Single-center randomized trail focused on tracheostomized patients with severe acquired brain injury , comparing two different decannulation protocols: 1.
- Trial name
- NCT04835272
- Testing
- the Decannulation Protocol With Suctioning
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Mechanical Ventilation Complication, Upper Airway Obstruction
Nasal Mask Ventilation During the Induction of General Anesthesia
Recently, the investigators demonstrated that nasal route ventilation is superior to the nasal-oral combined ventilation in the absence of jaw thrust and chin up maneuvers.
- Trial name
- NCT01651286
- Testing
- nasal mask, full face mask
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Cardiac Arrest
Pragmatic Airway Resuscitation Trial
The primary objective of the trial is to determine if 72-hour survival after out-of-hospital cardiac arrest (OHCA) is improved with initial endotracheal intubation (ETI) over initial laryngeal tube (LT) airway management…
- Trial name
- PART (NCT02419573)
- Testing
- Endotracheal Intubation, Laryngeal Tube (King)
- Where
- 6 sites in United States
- Volunteers
- 3,004 people
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease
Chronic Airway Disease, Mucus Rheology and Exacerbations
The main objective of this trial is to compare the exacerbation number over 12 months of follow-up between a group of patients with COPD treated according to standardized management (azithromycin prescribed in the event of severe…
- Trial name
- COPD-CARhE (NCT04339270)
- Testing
- Azithropycin according to symptoms, Azithromycin according to rheology or symptoms
- Where
- 3 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis, Pseudomonas Aeruginosa
Sino-nasal Inhalation of Colistin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonization
The purpose of this study is to determine whether the nasal inhalation of Colistin is effective to decrease the Pseudomonas aeruginosa bacterial count in the nasal lavage fluid.
- Trial name
- NCT01035853
- Testing
- Colistin
- Where
- 3 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University of Jena
Malignant Airway Obstruction
A Trail of a Novel Tracheal Radioactive Stent for the Malignant Airway Obstruction
The aim of this study was to evaluate the safety and effectiveness of an radioactive airway stent loaded with 125I seeds compared to a conventional airway stent in patients with malignant airway obstruction caused by both primary…
- Trial name
- NCT02565927
- Testing
- Traditional airway stent, Iodine-125 seeds
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongda Hospital
Respiratory Insufficiency, Respiratory Distress Syndrome, Adult
Continuous Positive Airway Pressure (CPAP) Ventilation Using a Novel Full-Face Mask Versus Conventional Helmet
The aim of this study is to compare two methods of delivery of noninvasive mechanical ventilation (NIV). Since patient compliance and mechanical characteristics of the delivery devices are two fundamental variables in the success…
- Conditions
- Respiratory Insufficiency, Respiratory Distress Syndrome, Adult, Chronic Obstructive Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT00944437
- Testing
- Helmet, Full-face mask
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- University of Parma
COPD, COPD Exacerbation
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
To demonstrate the additional benefit of roflumilast when added on to fixed-dose combination (FDC) LABA/ICS in the reduction of exacerbations in subjects with severe to very severe COPD.
- Conditions
- COPD, COPD Exacerbation, Lung Diseases, Respiratory Disorders
- Trial name
- NCT01443845
- Testing
- Roflumilast
- Where
- 338 sites in United States, Argentina and 15 more
- Volunteers
- 2,354 people
- Sponsor
- AstraZeneca
Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease
Treatment With AKL1 in Obstructive Airways Disease (The TAKL Study)
Obstructive airways disease is a very common condition. This condition includes patients with asthma, chronic obstructive pulmonary disease (COPD), emphysema or chronic bronchitis.
- Conditions
- Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- TAKL (NCT00920127)
- Testing
- AKL1
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- University of East Anglia
Intubation; Difficult or Failed, Muscle Relaxation
Use of Muscle Relaxants in Parotidectomy Operation With Neuromonitoring
Neuromuscular blockers provide muscle relaxation by blocking the electrical conduction to motor nerves and facilitate endotracheal tube placement while relaxing the whole body for surgical comfort during general anesthesia.
- Conditions
- Intubation; Difficult or Failed, Muscle Relaxation, Anesthesia Intubation Complication, Airway Complication of Anesthesia
- Trial name
- NCT05432570
- Testing
- Group A - Muscle Relaxants Used, Group B - No Muscle Relaxants
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Epistaxis, Nasal Obstruction
The Effect of Packing in Post Operative Management of FESS
Chronic sinusitis is a very common problem. The functional endoscopic sinus surgery is a prevalent option to treat this disease.During usage of different techniques of surgery, the need for packing after surgery is debatable…
- Conditions
- Epistaxis, Nasal Obstruction, Pain
- Trial name
- NCT00793117
- Testing
- packing
- Where
- Iran
- Volunteers
- 66 people
- Sponsor
- Tehran University of Medical Sciences
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