Clinical trials: Airway Disease
Obstructive Sleep Apnea
Efficacy and Safety of keepMED Positive Airway Pressure Device in Patients With Obstructive Sleep Apnea
A prospective, multi-centre, single-arm, open-label, interventional study with a non-marketed medical device. The primary study objective is to assess the efficacy of the keepMED PAP device on modification of respiratory…
- Trial name
- keePaOSA (NCT04875897)
- Testing
- keepMED PAP device
- Volunteers
- 65 people
- Sponsor
- keepMED Ltd.
Sleep Apnea, Obstructive, Asthma, Exercise-Induced
Pulmonary Disorders During Exercise in Patients With Obstructive Sleep Apnea
Purposes: 1. To investigate whether patients with severe obstructive sleep apnea syndrome (OSAS) are at higher risk for exercised-induced bronchoconstriction (EIB) due to baseline airway inflammation compared with age, gender…
- Trial name
- NCT00916773
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Intubation Complication, PreTerm Birth
NIPPV Versus Bi-level Nasal Continuous Positive Airway Pressure Following Extubation
Mechanical ventilation is important in the care of preterm infants with respiratory failure, but may be associated with lung injury. Efforts are needed to avoid or minimize the use of mechanical ventilation.
- Trial name
- NCT02842190
- Testing
- NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Acute Respiratory Failure
Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial
The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade…
- Trial name
- ANGLE (NCT07223762)
- Testing
- Hyperangulated video laryngoscope blade, Standard geometry video laryngoscope blade
- Where
- 19 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea (OSA)
The Effectiveness of Perioperative CPAP to Reduce Obstructive Sleep Apnea Related Adverse Events
Objective of the study: To determine whether Perioperative Auto-CPAP treatment prevent postoperative worsening of OSA and improve nocturnal oxygen saturation in surgical patients with moderate and severe OSA.
- Trial name
- NCT01249924
- Testing
- auto-titrated CPAP, Control
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Allergic Rhinitis
Alpha-Blockers in Allergic Rhinitis (MAN 01)
Allergic rhinitis (allergic inflammation of the nose) is a common medical condition which is known to seriously decrease quality of life, aggravate preexisting conditions particularly asthma, carry significant medical treatment…
- Trial name
- MAN01 (NCT01946035)
- Testing
- Doxazosin XL
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Dundee
Asthma
BURAN: Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging
This study will assess the effects of benralizumab on airway dynamics in severe eosinophilic asthma in terms of quantitative computed tomography (CT)-derived measurements of pulmonary structure and function using the Functional…
- Trial name
- BURAN (NCT05552508)
- Testing
- Benralizumab
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 45 people
- Sponsor
- AstraZeneca
Ear Deformities, Acquired, Ear; Deformity, Congenital
Evaluation of the Auryzon Devices in the Optimization of Ear and Nose Reconstruction Procedures
This study evaluates the efficacy of the AuryzoN devices in the ear and nose reconstruction surgeries, both in terms of operative time and overall quality of reconstruction.
- Conditions
- Ear Deformities, Acquired, Ear; Deformity, Congenital, Microtia, Nose Deformity
- Trial name
- NCT03624608
- Testing
- AuryzoN Family of Devices
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Reconstrata, LLC
Chronic Obstructive Pulmonary Disease
Effect of Increased Fruit and Vegetable Intake on Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is the UK's fastest growing fatal disease and is estimated to cost the health service close to £1 billion every year. Around 80,000 people in Northern Ireland suffer from COPD.
- Trial name
- DISCO (NCT00435708)
- Testing
- 5 portions fruit and vegetables/day
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- Queen's University, Belfast
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Bariatric Surgery Candidate, Atelectasis, Postoperative Pulmonary
Ventilation Distribution After Bariatric Surgery
Obese patients have an increased risk of developing post-operative respiratory complications due to their comorbidities. They have a restrictive ventilatory defect with reduction of lung volumes and expiratory flow limitation…
- Trial name
- NCT03975348
- Testing
- High flow nasal cannula, Continuous positive airway pressure, Facemask
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Trieste
Asthma, Airway Inflammation
Pioglitazone Hydrochloride (Actos(Registered Trademark)) to Treat Asthma
This study will test whether pioglitazone hydrochloride (Actos (Registered Trademark) Registered Trademark) is effective for treating patients with asthma who do not respond to standard therapy.
- Conditions
- Asthma, Airway Inflammation, Airflow Obstruction, Airway Hyperactivity
- Trial name
- NCT00604578
- Testing
- Pioglitazone Hydrochloride
- Where
- 2 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COPD, Chronic Obstructive Pulmonary Disease
A Study to Assess the Effects of PT001 and PT005 MDI on Specific Image Based Parameters in Subjects With Moderate to Severe COPD
To assess the effect of treatment with Glycopyronnium (GP) MDI administered twice daily (BID) and Formoterol Fumarate (FF) MDI administered BID on specific image-based airway volumes and resistance in subjects with moderate to…
- Trial name
- NCT02937584
- Testing
- GP MDI (PT001) 14.4 μg, FF MDI (PT005) 9.6 μg
- Where
- 2 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Pearl Therapeutics, Inc.
Nasal Airway Obstruction
Measuring Nasal Airway Changes After VivAer Treatment Using AI Analysis
The goal of this clinical trial is to measure changes in the nasal airway after treatment with the VivAer® procedure in adults aged 22 to 85 with nasal airway obstruction caused by nasal valve dysfunction.
- Trial name
- BREATHE AI (NCT07574918)
- Testing
- VivAer Stylus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Aerin Medical
Sleep Apnea, Obstructive
Comparison of Breathing Events Detected by the SleepStyle 200 Auto Continuous Positive Airway Pressure (CPAP) Device to Attended Polysomnography
Obstructive Sleep Apnoea (OSA) is a common sleep-breathing disorder affecting around 2-4% of the population and is characterised by loud snoring, periodic collapse of the upper airway particular to sleep, sleep fragmentation, and…
- Trial name
- NCT00697424
- Testing
- SleepStyle 200 Auto Series CPAP Humidifier
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Allergic Asthma, Airway Remodelling
Eosinophil Induced Remodelling in Asthma
Asthma is a chronic, inflammatory disease of the lung characterized by intermittent airway obstruction, airway hyperresponsiveness, presence of activated inflammatory cells, inflammatory mediators, and airway structural changes.
- Trial name
- ERA (NCT02648074)
- Testing
- Bronchial challenge with allergen, Co-culture formation
- Where
- Lithuania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Bronchial Asthma
Effects on Small Airways of Two Long-term Extrafine Treatments in Asthma
New formulations of extrafine particles of long acting beta-2 agonists+inhaled corticosteroids (LABA+ICS) are able to reach more peripheral regions of the lung.
- Trial name
- FORTINO (NCT01255579)
- Testing
- Salmeterol Fluticasone, formoterol - beclometasone
- Volunteers
- 10 people
- Sponsor
- Università degli Studi di Brescia
Respiratory Distress Syndrome, Newborn
Diaphragm Electrical Activity of Preterm Infants on nCPAP Versus NIHFV
Preterm babies have immature lungs and frequent pauses in their breathing which often necessitates breathing support. Nasal Continuous Positive Airway Pressure (nCPAP) is one of the most commonly used tools, but does not always…
- Trial name
- NCT02267018
- Testing
- Drager VN500 Ventilator
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Lung Disease
Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease
To determine the utility and sensitivity of the lung clearance index (LCI) technique as a marker of small airways disease in adults with chronic lung conditions compared to healthy adults, adjusting for age, sex and smoking…
- Trial name
- NCT03241420
- Testing
- lung clearance index (LCI)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Malformation Brain
Neuroradiology Assesses Chiari Malformation's Impact on Airways, Cranial Base, and Sleep Disorders in Children.
The severity of sleep disorders in patients with Chiari malformations can vary. The investigators propose to establish a correlation between the severity of sleep-disordered breathing (SDB) and the quantitative neuroradiological…
- Trial name
- CHDSB (NCT05913297)
- Testing
- Magnetic Resonance, Polysomnographic evaluation
- Where
- Italy
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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