Clinical trials: Airway Disease
Obstructive Sleep Apnea, Nasal Congestion
Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure
1. CPAP compliance will be significantly higher in both the heated humidity with Thermosmart™ and the nasal steroid phases compared to the double placebo phase. 2.
- Conditions
- Obstructive Sleep Apnea, Nasal Congestion, Sinus Congestion
- Trial name
- Thermosmart (NCT00665977)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Clayton Sleep Insititute
COPD (Chronic Obstructive Pulmonary Disease)
Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab
The goal of this study is to evaluate the effect of mepolizumab on patients with COPD using MRI and CT imaging as well as breathing tests.
- Trial name
- ADORE (NCT07749001)
- Testing
- Mepolizumab 100 MG Injection
- Volunteers
- 36 people
- Sponsor
- Western University, Canada
Sleep Apnea, Stroke
Usefulness of Nasal Continuous Positive Airway Pressure (CPAP) Treatment in Patients With a First Ever Stroke and Sleep Apnea Syndrome
MAIN AIMS: to analyze the efficacy of nasal CPAP treatment in patients with ischemic first-ever stroke and Sleep Apnea Syndrome (SAS) in terms of: early neurological outcome, functional recovery, quality of life influence, stroke…
- Conditions
- Sleep Apnea, Stroke, Cardiovascular Disease
- Trial name
- NCT00202501
- Testing
- Nasal CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Depression, Sleep Apnea, Obstructive
Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)
The purpose of the study is to determine the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and associated OSA (obstructive sleep apnea).
- Trial name
- NCT00441636
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University
Pierre Robin Syndrome
Early Treatment Outcomes in Pierre-Robin-Like Phenotype
In a longitudinal cohort study, we want to assess the effect of the pre-epiglottic baton plate, the main treatment approach currently used in Germany for Pierre-Robin-Like phenotype, on upper airway obstruction and failure to…
- Trial name
- NCT02266043
- Testing
- Pre-epiglottic baton plate (PEBP)
- Where
- 3 sites in Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Chronic Obstructive Pulmonary Disease
Continuous Positive Airway Pressure Effect on Air Trapping in Chronic Obstructive Pulmonary Disease Patients
Chronic obstructive pulmonary disease is a disease characterized by small airways inflammation and obstruction. The small airways disease produces hyperinflation (air trapping), which increases with exercise.
- Trial name
- CPAP (NCT01507844)
- Testing
- positive ventilation
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Assaf-Harofeh Medical Center
Asthma
Effects of Montelukast on Airway Regulatory T Cells in Asthma
Montelukast is one of anti-inflammatory agents and a good controller for the patients with asthma. The hypothesis of the study is that the Montelukast will have airway anti-inflammatory effects and up-regulated regulatory T cells…
- Trial name
- NCT01951898
- Testing
- Montelukast
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- Kurume University
Chronic Obstructive Pulmonary Disease
Combined Effects of Blow Bottle Technique and Percussion Technique in COPD Patients
It will be a randomized control trial. Participants will be recruited according to inclusion criteria and will be allocated into 2 groups using convenience sampling technique.
- Trial name
- NCT05922293
- Testing
- blow bottle, percussion
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal
The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General Anesthesia
The application of lidocaine cream on oral secretions of LMA removal during the recovery period in ophthalmic surgical patients under general anesthesia: a randomized controlled trial
- Conditions
- Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal, Anesthesia Emergence, Secretion; Excess, Salivation
- Trial name
- LICOS (NCT06967064)
- Testing
- lidocaine cream
- Sponsor
- Sun Yat-sen University
Obstructive Sleep Apnea (OSA)
Evaluation of Treatment Efficacy and Comfort of a Modified Positive Airway Pressure Device to Treat Obstructive Sleep Apnea.
This study will test the hypothesis that the modified positive airway pressure (PAP) device for OSA will be no worse than a market released product in terms of its treatment efficacy, comfort and patient compliance.
- Trial name
- NCT02214238
- Testing
- PAP device
- Where
- New Zealand
- Volunteers
- 49 people
- Sponsor
- Fisher and Paykel Healthcare
Critical Illness, Difficult; Intubation, Postpartum, During Puerperium
Ultrasound Airway Assessment of Critically Ill Preeclamptic; Comparison Between Two Technique
Unexpected difficult airway exposes the patient to serious morbidity and even mortality. The changes in pregnancy and preeclampsia increase the risk of difficult intubation.
- Conditions
- Critical Illness, Difficult; Intubation, Postpartum, During Puerperium, Pre-Eclampsia
- Trial name
- NCT06651879
- Testing
- techniques of ultrasound examination of the airway
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Cancerous Lesions of the Oral Cavity
Spectrometry of Cancerous Lesions of the Oral Cavity
The detection of suspect lesions is based on the clinical examination of the oral cavity and pharyngolaryngeal endoscopy, but the examination to confirm the diagnosis is a pathology examination of the biopsy taken during the…
- Trial name
- SpectrORL1 (NCT02851420)
- Testing
- spectroscopy
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Apnea, Infant, Premature
Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants.
Very premature infants uniformly do not have mature functioning lungs to breathe well nor mature regulation mechanisms to breathe regularly. Assistance with a mechanical respirator is common.
- Conditions
- Apnea, Infant, Premature, Bronchopulmonary Dysplasia
- Trial name
- NCT00188968
- Testing
- Nasal Continuous Positive Airway Pressure, Synchronized Nasal Positive Pressure Ventilation
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Cleft Lip and Cleft Palate
Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate
Secondary rhino-septoplasty in unilateral cleft lip and palate is the treatment of choice for the correction of aesthetic deformities and the functional impact on ventilation nasal. It remains a difficult treatment.
- Trial name
- RHINOFENTE (NCT07048418)
- Testing
- Mailing and completing CLEFT-Q and NOSE questionnaires
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Obesity
Effect of Different-Flow High-Flow Nasal Cannula Versus Traditional Face Mask Oxygenation on Safe Apnea Time in Obese Patients
Obesity is a growing global health problem, and patients with obesity are at higher risk of hypoxemia during induction of general anesthesia.
- Trial name
- NCT07843810
- Testing
- Face Mask, High-Flow Nasal Cannula
- Where
- China
- Volunteers
- 147 people
- Sponsor
- The First People's Hospital of Lianyungang
Pregnancy
Studying Fetal Breathing Patterns
Some babies have difficulty breathing, sucking, and swallowing at birth. The purpose of this study is to determine (before birth) the variables that will predict whether a newborn will experience these problems.
- Trial name
- NCT00066976
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction
Prophylactic Use of APRV Before Extubation in Morbidly Obese Patients After Cardiac Surgery.
Morbidly obese patients undergoing open heart surgery are at increased risk of breathing problems after removal of the breathing tube due to reduced lung function and chest wall restriction following surgery.
- Conditions
- Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction, Mechanical Ventilation Strategies
- Trial name
- APRV-OBESE-CS (NCT07409324)
- Testing
- Airway Pressure Release Ventilation (APRV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Stroke, Acute, Obstructive Sleep Apnea
Continuous Positive Airway Pressure on Acute Stroke and Obstructive Sleep Apnea
Stroke affects 16.9 million individuals each year and is the second leading cause of death worldwide. Despite advances in pharmacologic therapy, morbidity , mortality and rates of hospitalization for stroke remain high.
- Trial name
- NCT04458779
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 71 people
- Sponsor
- Far Eastern Memorial Hospital
Asthma, Airway Obstruction
Single-dose Crossover Study to Investigate Pharmacodynamics of AZD3199
The purpose of this study is to investigate the pharmacodynamics of single doses of AZD3199 in asthmatic patients.
- Trial name
- NCT00736489
- Testing
- AZD3199, Formoterol
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep
The purpose of this study is to investigate the effect of nocturnal oxygen therapy during a stay at moderate altitude on breathing and sleep of patients with chronic obstructive lung disease.
- Trial name
- NCT02150590
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
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