Clinical trials: Airway Disease
Persistent Allergic Rhinitis
Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic Rhinitis
Persistent allergic rhinitis in children is commonly treated with intranasal corticosteroids (INS), which are considered first-line therapy.
- Trial name
- NCT07593898
- Testing
- Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg, Oxymetazoline 0.05% nasal solution
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Surgery, Pneumoperitoneum
Intra-Abdominal Pressure Effect on Intra-Abdominal Volume and Airway Pressures During Laparoscopy
During pneumoperitoneum insufflation the insufflated gas increase intra-abdominal pressure. The generated pressure can lead to a different increase in volume depending on the abdominal cavity and patients' characteristics.
- Conditions
- Surgery, Pneumoperitoneum, Intra Abdominal Pressure
- Trial name
- NCT04468698
- Testing
- Peritoneum insufflation
- Where
- Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitario La Fe
Cystic Fibrosis, Bronchiectasis
Adherence to Airway Clearance. Novel Approaches to Improving Adherence
An airway clearance technique (ACT) is one of the core treatments for children with chronic lung diseases who are unable to clear their secretions effectively.
- Trial name
- NCT02906826
- Testing
- Video game
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Asthma, Exercise-Induced, Asthma
Do Heat and Moisture Exchange Mask Reduce EIB and Cough Severity in Asthma
The overall aim of this study is to determine if face masks that can warm and humidify air can improve overall asthma control and markers of airway health during exercise in cold dry environments.
- Trial name
- NCT04302610
- Testing
- Heat and Moisture Exchange mask (ColdAvenger® expedition balaclava, USA,
- Volunteers
- 26 people
- Sponsor
- University of Kent
Lung Cancer
Ventilation Heterogeneity Prior to Lung Resection
This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed…
- Trial name
- NCT04191174
- Testing
- Hyperpolarized 129Xe MRI, Technegas V SPECT, Sputum Induction
- Where
- Canada
- Volunteers
- 115 people
- Sponsor
- McMaster University
Allergic Asthma
Analysis of Fel d 1-specific T Cells After Airway Allergen Challenge in Asthma
Cat allergies are a major trigger of asthma. Therapies are being developed to control the allergic response to cats. We are interested in measuring a type of white blood cell which is linked to cat allergies, which will help us…
- Trial name
- NCT01612715
- Testing
- Segmental Allergen Challenge
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Hamilton Health Sciences Corporation
Anesthesia Intubation Complication, Mechanical Ventilation Complication
Endotracheal Tube Audible Leak Test
The endotracheal tube (ETT) leak test (LT), or audible leak test is a widely performed assessment to verify appropriate tube size in neonates, infants and children.
- Trial name
- NCT02461017
- Testing
- Assess for Audible Endotracheal Leak, Assess for Endotracheal Leak with direct visualization under rigid bronchoscope
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Mississippi Medical Center
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges
The purpose of this exploratory study is to evaluate the effects of inhaled epinephrine in patients with known or suspected metabisulfite sensitivity who experience a systemic allergic reaction (SAR) while undergoing allergy…
- Trial name
- NCT06445374
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Dr. George Luciuk
OSAHS, Craniofacial Abnormalities
Upper-airway Changes After Bimaxillary Advancement in OSAHS
One of the most effective surgical treatments for obstructive sleep apnoea / hypopnoea syndrome (SAHS) with global impact on the upper-airway (UA) is the maxilla-mandibular advancement (MMA).
- Trial name
- OSAHS (NCT04301635)
- Testing
- Maxillo-mandibular Advancement + Counterclockwise rotation
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Hospital de Cruces
Obesity Hypoventilation Syndrome
Alternative of Treatment in Obesity Hypoventilation Syndrome
Primary objectives: evaluate the efficacy of noninvasive ventilation (NIV) treatment versus continuous positive airway pressure (CPAP) and life style modification treatment in Obesity Hypoventilation Syndrome (OHS), with PCO2…
- Trial name
- NCT01405976
- Testing
- life style modification, noninvasive ventilation, CPAP
- Where
- Spain
- Volunteers
- 440 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Respiratory Failure
Non-invasive Ventilation for Extubation Success in Infants Less Than 1,250 Grams
In preterm infants, endotracheal mechanical ventilation is well known to cause various forms of lung injury including volutrauma, barotrauma and oxytrauma - collectively known as ventilator-induced lung injury (VILI).
- Trial name
- NOVEL (NCT02051491)
- Testing
- BP-NCPAP, NIHFV
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Nasal Obstruction
The Effectiveness of Nasal Corticosteroids Versus Placebo in Nasal Obstruction in Patients With Nasal Septal Deviation
The purpose of this project is to determine if intranasal corticosteroids have an effect on nasal obstruction in patients with nasal septal deviation.
- Trial name
- NCT02877485
- Testing
- Triamcinolone Acetonide, Ayr saline nasal mist
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Stanford University
Tracheostomy, Oral Cancer
Novel Tracheostomy Tube Fixation Device in Oral Cancer Patients
This study evaluated a novel tracheostomy tube fixation device in post-tracheostomy patients with oral cancer. After tracheostomy, conventional fixation methods may be associated with skin pressure injury, wound contamination…
- Conditions
- Tracheostomy, Oral Cancer, Post-Tracheostomy Care, Tracheostomy Complications
- Trial name
- NCT07701226
- Testing
- Novel Self-Adhesive Bidirectional Tracheostomy Tube Fixation Device, Routine Tracheostomy Care and Conventional Fixation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Sleep Apnea, Hypertension
Effect of Continuous Positive Airway Pressure (CPAP) Treatment in the Control of Refractory Hypertension
The working hypothesis for the present study is that treatment with CPAP in patients with an sleep apnea (IAH>15) and AHT-r is capable of producing significant reductions in blood-pressure levels.
- Trial name
- NCT00616265
- Testing
- CPAP
- Where
- Spain
- Volunteers
- 210 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Snoring, OSA - Obstructive Sleep Apnea
Serene Sleep Palatal Implant System Clinical Confirmatory Trial in Participants Who Snore or Are Diagnosed With Mild-to-moderate Obstructive Sleep Apnea (OSA).
This clinical investigation is a prospective, non-randomized, parallel-group clinical investigation conducted at two (2) investigative sites.
- Trial name
- NCT07613281
- Testing
- Palatal Implant System
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Serene Sleep, Inc.
COPD
Effect of Roflumilast on Airway Blood Flow as an Expression of Airway Inflammation in COPD
The objectives of the proposed study are to determine 1) the effect of a single dose of Roflumilast on airway blood flow (Qaw) (study period 1) and 2) the effect of long-term Roflumilast treatment on airway blood flow reactivity…
- Trial name
- NCT02097992
- Testing
- Roflumilast
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Miami
Influenza
Phase 3 Efficacy and Safety Study of Favipiravir for Treatment of Uncomplicated Influenza in Adults
The purpose of this study is to determine if favipiravir is effective in reducing the time to resolution of influenza symptoms.
- Trial name
- NCT02008344
- Testing
- favipiravir
- Where
- 247 sites in United States, Argentina and 9 more
- Volunteers
- 1,161 people
- Sponsor
- MDVI, LLC
Chronic Rhinosinusitis (Diagnosis)
Aggravated Airway Inflammation: Research on Genomics and Optimal Medical Care (AirGOs-medical)
The study is performed as a randomized double-blinded prospective controlled trial. A total of 72 adult Acetyl salicylic acid (ASA) -exacerbated respiratory disease (AERD) -patients with uncontrolled chronic rhinosinusitis with…
- Trial name
- AirGOs-med (NCT03825757)
- Testing
- Acetyl Salicylic Acid
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Sanna Salmi
Breathing Exercises
Breathing Exercises on Lung Function
aim of this study is to evaluate the efficacy of pulmonary rehabilitation program as a non-pharmacological treatment method to: Improve functional capacity as assessed by six-minute walking distance (6MWD) test.
- Trial name
- NCT06472167
- Testing
- Breathing exercises
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University Hospital
Asthma
Effects of Anti-TSLP in Patients With Asthma
The purpose of this study is to determine whether anti-TSLP will decrease airway hyperresponsiveness in patients with asthma already on daily treatment with inhaled corticosteroids.
- Trial name
- UPSTREAM (NCT02698501)
- Testing
- MEDI9929
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Celeste Porsbjerg
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