Clinical trials: Airway Disease
Asthma, Vitamin D Deficiency
Vitamin D Deficiency and Asthma Exacerbation
The study aim is in two phases. First phase: to evaluate the influence of vitamin D deficiency on asthma severity, degree of airway obstruction and frequency of asthma exacerbations.
- Conditions
- Asthma, Vitamin D Deficiency, Disease Exacerbation
- Trial name
- AVD (NCT02661191)
- Testing
- oral cholecalciferol
- Volunteers
- 119 people
- Sponsor
- University of Turin, Italy
Allergic Asthma, Airway Remodelling
Eosinophil Induced Remodelling in Asthma
Asthma is a chronic, inflammatory disease of the lung characterized by intermittent airway obstruction, airway hyperresponsiveness, presence of activated inflammatory cells, inflammatory mediators, and airway structural changes.
- Trial name
- ERA (NCT02648074)
- Testing
- Bronchial challenge with allergen, Co-culture formation
- Where
- Lithuania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Obstructive Sleep Apnea
Nasal Airway Stent (Nastent®) Study in OSA
This study intends to assess the effect of nasal airway stent (Nasten®) as a treatment modality in patients with sleep-disordered breathing (SDB) including snoring and/or obstructive sleep apnea (OSA).
- Trial name
- Nastent (NCT04305964)
- Testing
- Nastent® (a distally perforated soft silicon nasal tube), Polygraphy with WatchPAT™ 300
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Increasing the Use of an Anti-snoring Mouth Guard (Mandibular Advancement Appliance) to Prevent Upper Airway Collapse During Sleep in Patients With Obstructive Sleep Apnoea.
Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder that is characterized by the repeated collapse of the upper airway during sleep, resulting in sleep deprivation.
- Trial name
- IPOSAT (NCT04092660)
- Testing
- Behaviour change Intervention Based on Health Action Process Approach Model, Mandibular Advancement Appliance (MAA) or Anti-snoring mouth guard
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Queen Mary University of London
Obstructive Sleep Apnea, Malocclusion
Changes in Upper Airway Anatomy, Quality of Life Measures, and Polysomnographic Parameters Using A Functional Dental Appliance
A prospective study measuring changes in upper airway anatomy, quality of life measures, and polysomnographic parameters using a functional dental appliance (Homeoblock)
- Trial name
- NCT02805764
- Testing
- Homeoblock
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Obstructive Airway Diseases
Physiological Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP
This experimental physiologic study is conducted to determine the effect of different mechanical ventilation settings (in terms of positive end-expiratory pressure) on patients receiving mechanical ventilation with expiratory…
- Trial name
- NCT07611409
- Testing
- PEEP titration
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Donación Francisco Santojanni
Nasal Obstruction, Septoplasty Surgeries
Effects of Surgical Correction of Nasal Obstruction on Oxygen Uptake and Ventilation Volume
This retrospective study aims to evaluate the effect of surgical correction of nasal obstruction on aerobic performance parameters in male athletes aged 20-32 years.
- Conditions
- Nasal Obstruction, Septoplasty Surgeries, Athletic Performance
- Trial name
- NCT06957262
- Testing
- Surgical correction of nasal obstruction
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Tuba Melekoğlu
Sleep Apnea Syndrome, Coronary Artery Disease
Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure
Published data indicate that obstructive sleep apnea syndrome (OSAS) worse the prognosis of coronary artery disease (CAD) and that oxidative stress can link this 2 diseases.
- Trial name
- CardioX SAS (NCT02893865)
- Testing
- Continuous positive airway pressure
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Healthy Volunteers, COPD GOLD I to IV
Demonstration of Broncholytic Effects in Subjects With Obstructive Airway Diseases by Low Frequency Ultrasound
This study is aiming at evaluating whether low frequency ultrasound spectroscopy is a sensitive tool to detect broncholytic effects in patients with obstructive airway diseases.
- Conditions
- Healthy Volunteers, COPD GOLD I to IV, Asthma GINA 1 to 4
- Trial name
- Pabes (NCT01080924)
- Testing
- Low frequency ultrasound spectroscopy after broncholysis
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal
The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General Anesthesia
The application of lidocaine cream on oral secretions of LMA removal during the recovery period in ophthalmic surgical patients under general anesthesia: a randomized controlled trial
- Conditions
- Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal, Anesthesia Emergence, Secretion; Excess, Salivation
- Trial name
- LICOS (NCT06967064)
- Testing
- lidocaine cream
- Sponsor
- Sun Yat-sen University
Airway Obstruction
Scoring System to Predict Depth of Cricothyroid Membrane
This study looks to devise a scoring system that can be used to predict difficult front of neck access due to increased depth of cricothyroid membrane.
- Trial name
- NCT03656315
- Testing
- Airway Assessment
- Where
- United Kingdom
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Obstructive Sleep Apnea
An Investigation to Test the Efficacy of the High Flow (HF) Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea (OSA)
Phase One: High Flow (HF) CPAP (HF-CPAP) Titration: Participants will attend the sleep lab to undergo a comprehensive split-night respiratory PSG.
- Trial name
- NCT01025440
- Testing
- Continuous Positive Airway Pressure
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Fisher and Paykel Healthcare
Primary Ciliary Dyskinesia, Kartagener Syndrome
Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies
Though common, morbidities related to upper airway disease in primary ciliary dyskinesia (PCD) and primary immunodeficiencies (PID) have not been fully characterized.
- Conditions
- Primary Ciliary Dyskinesia, Kartagener Syndrome, Primary Immune Deficiency
- Trial name
- NCT04919018
- Where
- 4 sites in United States, Canada
- Volunteers
- 159 people
- Sponsor
- University of North Carolina, Chapel Hill
Sedation for Gastroenteric Endoscopic Procedure, Deglutition Disorders
Valuation of Swallowing in Patient Sedated for Gastroenteric Endoscopic Procedure
Aim of this study is to evaluate swallowing functionality in patient sedated for gastroenteric endoscopic procedure. Swallowing will be study by laryngeal fibroscopy and evaluate using Penetration-Aspiration Scale and Aspiration…
- Conditions
- Sedation for Gastroenteric Endoscopic Procedure, Deglutition Disorders, Aspiration of Food
- Trial name
- SwallSed (NCT01789424)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale San Raffaele
Nasal Obstruction
Efficacy of an Intranasal Stent on Nasal Obstruction at Night
This study aims to demonstrate a decrease with normalization of nasal resistance in the forward decubital position and with an intra-nasal stent in patients with nasal obstruction.
- Trial name
- RHINASTENT (NCT04228016)
- Testing
- Device: nastent™
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Cystic Fibrosis (CF)
Autogenic Drainage Versus Mechanical Percussion in Children With Cystic Fibrosis
The goal of this clinical trial is to compare the effects of autogenic drainage and mechanical percussion on lung function, dyspnea, and quality of life in children with cystic fibrosis.
- Trial name
- ADMP-CF (NCT07729787)
- Testing
- Autogenic Drainage, Mechanical Percussion
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Down Syndrome, Obstructive Sleep Apnea
Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
- Trial name
- NCT04132999
- Testing
- Family-informed intervention, Standard Clinical Care
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Asthma
Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study
Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway…
- Trial name
- NCT00841425
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Chronic Obstructive Pulmonary Disease
Efficacy and Safety Study of Two Fixed-dose Combinations of Aclidinium Bromide With Formoterol Fumarate Compared With Aclidinium Bromide, Formoterol Fumarate and Placebo
The purpose of this study is to evaluate the efficacy of this multicenter, randomized, double-blind, placebo-controlled, 4-period, incomplete-block crossover, dose-ranging study comparing 2 fixed dose combinations (FDCs) of…
- Trial name
- LAC-MD-27 (NCT01049360)
- Testing
- Aclidinium 400 μg / Formoterol 12 μg, Aclidinium 400 μg / Formoterol 6 μg, Aclidinium 400 μg
- Where
- 20 sites in United States
- Volunteers
- 128 people
- Sponsor
- AstraZeneca
Nasal Obstruction, Apnea, Obstructive Sleep
The Role of the Nose in Snoring and Sleep Apnea
We intend to study, in depth, the quantitative and qualitative properties of nasal respiration in sleep-disordered breathing and sleep apnea and its relation to (CPAP) treatment with the final goal of improving patient outcome.
- Trial name
- NCT03072173
- Testing
- Xylometazoline
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Lovisenberg Diakonale Hospital
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