Clinical trials: Airway Hyperresponsiveness
Asthma
Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male Patients With Asthma
Asthma is a chronic inflammatory bronchial disorder with three distinct components: airway hyper-responsiveness (respiratory hypersensitivity), airway inflammation, and intermittent airway obstruction.
- Trial name
- NCT01577953
- Testing
- SB010
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Sterna Biologicals GmbH & Co. KG
Asthma
Asthma and Allergy Screening AA2000 (Cross Sectional)
Asthma screening of 493 asthma patients
- Trial name
- AA2000 (NCT04727112)
- Testing
- Usual care versus primary care
- Volunteers
- 493 people
- Sponsor
- Bispebjerg Hospital
Asthma
Study to Assess the Efficacy of a Single PBF-680 Oral Administration to Attenuate Adenosine 5'-Monophosphate Challenge-induced Airway Hyperresponsiveness in Mild-to-moderate Asthmatics
This is a single-center, double-blind, randomized trial utilizing a three-period, balanced block design, with each period comprising a unique study product administration.
- Trial name
- NCT01939587
- Testing
- PBF-680 5 mg, PBF-680 20 mg
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Asthma, Bronchial Hyperreactivity
Early Antiinflammatory Treatment of Asthma
The inflammatory process that leads to the development of asthma may be present before the onset of asthma symptoms and cause a certain degree of airway hyperresponsiveness.
- Trial name
- EATA (NCT00567463)
- Testing
- Fluticasone
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Laval University
Asthma
Tezepelumab Treatment in Korean Severe Asthma Patients
There is no study that systematically evaluated the effect of Tezepelumab on cough, and based on this background, the present researchers aimed to evaluate the effect of Tezepelumab treatment in patients with severe asthma who…
- Trial name
- NCT06438913
- Testing
- Tezepelumab
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Bronchitis
Functional Implications of TNF
The research plan proposes to develop translational studies in humans that will identify host susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
- Trial name
- NCT00729131
- Testing
- Etanercept inhibition of ozone-induced airway hyper-responsiveness.
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Healthy
Alcohol Exposure and Airway Hyperresponsiveness
Alcohol has consequences including increased risk for upper respiratory tract infections, pneumonia, acute respiratory distress syndrome (ARDS), and alcohol-induced asthma.
- Trial name
- NCT00990275
- Testing
- ethanol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Asthma
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
The trial is an investigator-driven research study in subjects with intermittent asthma, the aim of which is to explore the likelihood of a functionally important separate leukotriene E4 (LTE4) receptor in airways and/or…
- Trial name
- E-Type (NCT01841164)
- Testing
- Montelukast, Inhaled leukotriene E4
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Karolinska University Hospital
Asthma, Airway Hyperresponsiveness
Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are…
- Trial name
- proto nage (NCT00686452)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laval University
Asthma
Duration of Protective Effect From Inhaled Ipratropium Bromide on Methacholine Airway Hyperresponsiveness
Certain lung disease medications can influence diagnostic tests and research investigations. This study will investigate how long ipratropium bromide must be withheld before a methacholine challenge test can be conducted.
- Trial name
- NCT00605410
- Testing
- ipratropium bromide
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Saskatchewan
Asthma
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers.
The prevalence of airway hyperresponsiveness (AHR) is very high in elite swimmers, reaching 80% in certain studies. Repeated Chlorine-derivatives exposure may be a major causative factor for its development.
- Trial name
- NCT00876135
- Testing
- Ventolin
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- Laval University
Airway Hyper Responsiveness
Determining Baseline Respiratory Duty Cycles in Subjects With and Without Airway Hyperresponsiveness
The study investigates the inspiratory duty cycle in subjects with and without airway hyper-responsiveness both at rest and during a bronchoprovocation challenge.
- Trial name
- NCT04001465
- Testing
- Volumetric methacholine challenge unmodified, Modified volumetric methacholine challenge
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Allergic Asthma
Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
BDNF has been linked to the pathogenesis of airway hyperresponsiveness in asthma. In this trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on BDNF concentrations will be assessed in patients with…
- Trial name
- NCT00736801
- Testing
- Salmeterol and Salmeterol / Fluticasone
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University of Rostock
Asthma
Asthma Intervention Research (AIR) Trial
The purpose of this study is to demonstrate the effectiveness and safety of the Alair System for the treatment of asthma. This will be a multicenter, randomized controlled study comparing the effects of treatment with the Alair…
- Trial name
- NCT00214526
- Testing
- Bronchial thermoplasty with the Alair System, Conventional therapy with ICS+LABA
- Volunteers
- 112 people
- Sponsor
- Asthmatx, Inc.
Asthma
Sensitivity and Specificity of Aridol Challenge for a Diagnosis of Asthma by a Specialist Pulmonologist
The purpose of this study is to estimate the sensitivity, specificity and positive and negative predictive values of a positive Aridol challenge with respect to a specialist pulmonologist diagnosis of asthma in corticosteroid…
- Trial name
- NCT00491153
- Where
- 3 sites in Norway
- Volunteers
- 35 people
- Sponsor
- St. Olavs Hospital
Asthma
Effect of Dietary Supplements With Fish Oil on Mannitol-induced Airway Sensitivity & Inflammation in Persons With Asthma
We wish to investigate the effects of 3 weeks of orally administered fish oil supplements on the airway sensitivity (provoking dose to cause a 15% fall in FEV1, PD15) to inhaled mannitol (AridolTM).
- Trial name
- NCT00526357
- Testing
- omega-3 fatty acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Firestone Institute for Respiratory Health
Asthma
Investigation of Novel Procedure for Methacholine Challenge Testing
The study will compare a novel volumetric method (performed with the Aerogen Solo vibrating mesh nebulizer) with the standard two-minute tidal breathing protocol (performed with the Wright jet nebulizer) for methacholine…
- Trial name
- NCT02965482
- Testing
- Wright Nebulizer, Aerogen Solo Nebulizer
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Saskatchewan
Asthma (Diagnosis), Airway Inflammation
Can Astaxanthin Help Manage Asthma in POlluted Areas?
This study will test whether astaxanthin, a naturally occurring antioxidant supplement, can improve lung function, reduce airway inflammation, and improve asthma control in adults with mild-to-moderate asthma.
- Conditions
- Asthma (Diagnosis), Airway Inflammation, Airway Hyperresponsiveness
- Trial name
- NCT07507682
- Testing
- Astaxanthin Oral Capsule
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Middlesex University
Asthma
The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance
This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance.
- Trial name
- NCT06224634
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Asthma, Airway Hyperresponsiveness
Bronchospasm Associated With High Nitric Oxide
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
- Trial name
- NCT00666510
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo