Clinical trials: Airway Hyperresponsiveness
Allergic Asthma
Effect of Xolair on Airway Hyperresponsiveness
The purpose of this study is to determine if Xolair can reduce the abnormal increase in limitation to airflow in patients with asthma in a relatively short time period.
- Trial name
- NCT00208234
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Creighton University
Asthma
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers.
The prevalence of airway hyperresponsiveness (AHR) is very high in elite swimmers, reaching 80% in certain studies. Repeated Chlorine-derivatives exposure may be a major causative factor for its development.
- Trial name
- NCT00876135
- Testing
- Ventolin
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- Laval University
Asthma, Airway Hyperresponsiveness
Bronchospasm Associated With High Nitric Oxide
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
- Trial name
- NCT00666510
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Asthma
Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male Patients With Asthma
Asthma is a chronic inflammatory bronchial disorder with three distinct components: airway hyper-responsiveness (respiratory hypersensitivity), airway inflammation, and intermittent airway obstruction.
- Trial name
- NCT01577953
- Testing
- SB010
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Sterna Biologicals GmbH & Co. KG
Asthma, Allergic
Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze.
- Trial name
- NCT05740748
- Testing
- Tezepelumab
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Asthma
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
The trial is an investigator-driven research study in subjects with intermittent asthma, the aim of which is to explore the likelihood of a functionally important separate leukotriene E4 (LTE4) receptor in airways and/or…
- Trial name
- E-Type (NCT01841164)
- Testing
- Montelukast, Inhaled leukotriene E4
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Karolinska University Hospital
Asthma, Airway Hyperresponsiveness
Small Airways Disease in Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness (AHR)
The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.
- Trial name
- ABHR (NCT01549483)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Asthma, Airway Hyperresponsiveness
Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are…
- Trial name
- proto nage (NCT00686452)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laval University
Asthma, Chronic Obstructive Pulmonary Disease
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration.
- Trial name
- NCT00279136
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Bronchitis
Functional Implications of TNF
The research plan proposes to develop translational studies in humans that will identify host susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
- Trial name
- NCT00729131
- Testing
- Etanercept inhibition of ozone-induced airway hyper-responsiveness.
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Allergic Asthma
Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
BDNF has been linked to the pathogenesis of airway hyperresponsiveness in asthma. In this trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on BDNF concentrations will be assessed in patients with…
- Trial name
- NCT00736801
- Testing
- Salmeterol and Salmeterol / Fluticasone
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University of Rostock
Asthma
How Airway Remodeling and Hyperresponsiveness Contribute to Airflow Obstruction in Asthma
Airway hyperresponsiveness is a characteristic feature of the asthma. It is known that there is an association between airway hyperresponsiveness and eosinophilic airway inflammation.
- Trial name
- NCT00186693
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Asthma, Bronchial
The Mannitol-Asthma-Ciclesonide-Study
Response of a 4 weeks treatment with daily once 320 µg ciclesonide on airway hyperresponsiveness assessed with mannitol. Hypothesis: Treatment with inhaled ciclesonide reduces airway hyper-responsiveness in 80% of…
- Trial name
- MACS (NCT03839433)
- Testing
- Ciclesonide
- Volunteers
- 72 people
- Sponsor
- Cantonal Hospital, Baselland
Asthma
Ciclesonide for the Treatment of Airway Hyperresponsiveness
The study objective is to investigate in a placebo-controlled, double-blind manner the effect of inhaled corticosteroid (ciclesonide) on airway hyperresponsiveness measured as having PD15 mannitol.
- Trial name
- NCT00826969
- Testing
- Ciclesonide
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- AstraZeneca
Asthma
Effect of Inhaled Ciclesonide in Adult Patients With Asthma (BY9010/M1-125)
Ciclesonide is a novel inhaled corticosteroid for the treatment of asthma. In this study the effect of ciclesonide on airway hyperresponsiveness (AHR), exhaled nitric oxide (NO), and induced sputum inflammatory biomarkers will be…
- Trial name
- NCT00546520
- Testing
- Ciclesonide
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- AstraZeneca