Clinical trials: Airway Inflammation
Chronic Obstructive Pulmonary Disease
Budesonide / Formoterol in Treatment of Exacerbations of COPD
The purpose of this study is to determine whether the budesonide+formoterol combination is effective in the treatment of exacerbations of COPD with a main emphasis on investigating the effects on inflammation and a secondary…
- Trial name
- NCT00239278
- Testing
- budesonide/formoterol, 2x 200/6 microgram. 4 times daily
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Heart Failure, Pulmonary Disease, Chronic Obstructive
Pulmonary Function, Chronic Obstructive Pulmonary Disease (COPD) Prevalence, and Systemic Inflammation in Chronic Heart Failure With or Without COPD
The aim of the present study is: 1. To investigate pulmonary function abnormalities (restriction, obstruction, diffusion impairment, mixed pulmonary defects) in patients with chronic heart failure (CHF) and to determine which of…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Inflammation
- Trial name
- NCT01429376
- Testing
- Pulmonary function tests, Blood tests, Questionnaires
- Where
- 2 sites in Netherlands
- Volunteers
- 234 people
- Sponsor
- Rijnstate Hospital
Asthma
Comparative Effects of Fish Oil Supplementation and a Montelukast on EIB and Airway Inflammation in Asthma
Combining fish oil supplementation and Montelukast [a commonly used cyst LT1 receptor antagonist to treat exercise-induced bronchoconstriction (EIB)] will provide a greater antiinflammatory effect against developing EIB that…
- Trial name
- NCT00676468
- Testing
- Active Montelukast + Active Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Elite Athlete, Healthy
Longitudinal Follow-up of High School Athletes
In this study the investigators will study the lung function and airway inflammation in elite athletes starting at the elite sport school (age: 12-13 year) and the change in lung function parameters and airway inflammation after…
- Trial name
- NCT02432183
- Where
- Belgium
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis in Adults, Chronic Colonization With Pseudomonas Aeruginosa
Detection of Reductions in Cystic Fibrosis Airway Inflammation While Using Aztreonam Lysine Solution
In cystic fibrosis, there is a critical need for better predictors of treatment response. The investigators have identified a panel of white blood cell biomarkers which can be directly measured as a blood test in subjects with…
- Trial name
- NCT01736839
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Jewish Health
Asthma
Study of TNFR:Fc (Enbrel) in the Treatment of Asthma
The proposed study is a phase II clinical trial of TNFR:Fc therapy in a segmental allergen bronchoprovocation model of atopic asthma.
- Trial name
- NCT00001893
- Testing
- TNFR:Fc
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Asthma
Inflammatory Processes in the Airway of Asthmatics With Persistent Bronchial Hyperreactivity
The purpose of this study is to examine inflammatory processes in the airway of moderate to severe persistent asthmatics who have persistent bronchial hyperreactivity despite chronic administration of inhaled glucocorticoids.
- Trial name
- NCT00217854
- Testing
- Bronchoscopic
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Airway Inflammation
Study of Biomarkers of Airway Inflammation (0000-128)
This study will evaluate the effects of inhaled fluticasone on cell counts and inflammatory mediators measured in sputum of healthy volunteers following exposure to inhaled lipopolysaccharide.
- Trial name
- NCT00869596
- Testing
- fluticasone propionate, Comparator: Lipopolysaccharide (LPS), Comparator: albuterol
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease (COPD)
Nitric Oxyde Concentration in Chronic Obstructive Pulmonary Disease Patients - SANOB Study
Among many other causes, Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is also caused by inflammation of peripheral airways walls.
- Trial name
- SANOB (NCT01853787)
- Testing
- Formoterol Fumarate, Salmeterol
- Where
- 2 sites in Italy
- Volunteers
- 49 people
- Sponsor
- University of Milan
ASTHMA
Breathing Training for Asthma
For the proposed randomized controlled treatment study, the investigators plan to compare the effects of this hypoventilation-based breathing training with a control intervention that will focus on breathing regularity and…
- Trial name
- NCT00975273
- Testing
- Capnometry Assisted Respiration Training, Breathing Awareness
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Southern Methodist University
Asthma (Diagnosis), Persistent Asthma
Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA)
In this single center, interventional pilot study, 40 participants at high risk for future exacerbation will be randomized to anakinra (v.
- Conditions
- Asthma (Diagnosis), Persistent Asthma, Moderate Asthma Exacerbation
- Trial name
- ARTMA (NCT07600190)
- Testing
- Anakinra 100 Mg/0.67 Ml Inj Syringe
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis
Non-Invasive Biomarkers in Cystic Fibrosis
Background Chronic airway inflammation is present in cystic fibrosis. Non-invasive inflammometry may be useful in disease management.
- Trial name
- NCT00413140
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Upper Airway, Irritation Inflammation, Discomfort
SENOC-I Det Sunda Huset II - Sensitization of Occupants of Water Damaged Buildings.
The study is focussed on two main questions: 1. The importance of dampness of the building and home dust as a factor of the subjects= responses. 2.
- Trial name
- NCT00143650
- Testing
- House dust
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Congenital Diaphragmatic Hernia
Airway Inflammation in Congenital Diaphragmatic Hernia Patients
We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway inflammation as a first step to characterize the reported bronchodilator responsiveness.
- Trial name
- NCT02453750
- Testing
- Hypersaline, Bronchodilator Response
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Asthma
Study to Explore the Effects of Two Hour Inhalation of Ultrafine Carbon Black Particles on Airway Inflammation in Asthmatics
The aim of the study is to test the hypothesis that the allergic airway inflammation in asthmatic patients will be enhanced after exposure to ultrafine particles (UFP).
- Trial name
- NCT00527462
- Testing
- Bronchoscopy, Exposure to ultrafine carbon black particles
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma, COPD
The Mixed Phenotype of Asthma and COPD: the Overlap Syndrome
RATIONALE: In asthmatic subjects, smoking can lead to several changes in disease characterictics. in smokers of more than 20 pack-years, chronic obstructive pulmonary disease (COPD) can be associated with asthma, also called…
- Trial name
- NCT03817333
- Where
- Canada
- Volunteers
- 115 people
- Sponsor
- Laval University
Nasal Congestion and Inflammations, Rhinitis
Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis
This is a multicenter clinical trial, phase III, non-inferiority, controlled by active medicine, open, randomized, enroll 538 children, 2 to 12 years old, with acute inflammation upper airway, characterized by nasal congestion…
- Trial name
- NCT01393548
- Testing
- brompheniramine + phenylephrine, Brompheniramine + pseudoephedrine
- Where
- Brazil
- Volunteers
- 879 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Airway Inflammation, Asthma
An Exploratory Study to Characterise Changes in Airway Inflammation, Symptoms, Lung Function and Reliever Use in Adult Asthma Patients
This is a randomised, active-comparator, open-label, parallel-group, multicentre phase IV exploratory study to characterise changes in airway inflammation, symptoms, lung function, and reliever use in asthma patients using SABA…
- Trial name
- NCT03924635
- Testing
- SYMBICORT and salbutamol
- Where
- 6 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- AstraZeneca