Clinical trials: Airway Pressure
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Nasal Continuous Positive Airway Pressure,, Preterm Infants,
Early NCPAP Before Surfactant Treatment in Very Preterm Infants With RDS
We hypothesis a period of early NCPAP before surfactant treatment is effective for treating RDS and preventing BPD in very premature infants.
- Conditions
- Nasal Continuous Positive Airway Pressure,, Preterm Infants,, Surfactant Treatment,, Respiratory Distress Syndrome,
- Trial name
- NCT01996670
- Volunteers
- 683 people
- Sponsor
- Xiangya Hospital of Central South University
Sleep Apnea, Obstructive
Adherence to Continuous Positive Airway Pressure Among Obstructive Sleep Apnoea Patients.
Prospective study designed to identify factors that would predict patient adherence to CPAP (Continuous Positive Airway Pressure) therapy.
- Trial name
- NCT02055027
- Testing
- Comparison between groups
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Astes
Diabetic Retinopathy, Sleep Apnea
CPAP Effect on the Progression of Diabetic Retinopathy in Patients With Sleep Apnea
Objectives: Main objective: To compare the percentage of patients with new microaneurysm or hard exudates after 12 months between the CPAP group and the control group.
- Trial name
- RetinAS (NCT02874313)
- Testing
- Continuous positive airway pressure, Pharmacological treatment, Conventional anti-diabetic diet recommendations
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Hospital Universitario La Paz
Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness
Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy
Abstract Objective: The aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed…
- Conditions
- Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness, Airway Complications, Respiratory Complications
- Trial name
- NCT07678086
- Testing
- Pressure Transducer, Traditional Palpation Method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Anesthesia, Intubation; Difficult or Failed
Paratracheal Esophagus Pressure on the Intubation With Pentax Airway Scope
Recently, left paratracheal pressure was introduced as an alternative method to prevent pulmonary aspiration instead of cricoid pressure.
- Conditions
- Anesthesia, Intubation; Difficult or Failed, Cricoid Pressure, Pulmonary Aspiration During Anesthetic Induction
- Trial name
- NCT04135651
- Testing
- Paratracheal pressure, Cricoid pressure
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Ajou University School of Medicine
ARDS, COVID19
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit).
- Trial name
- APRV-COVID19 (NCT04386369)
- Testing
- Airway pressure release ventilation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
Sleep Apnea, Dyslipidemias
CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea
Clinical Trial Phase IV Indication: Moderate-severe obstructive sleep apnea and dyslipidemia. Objectives: Main objective: To test whether 12 months of CPAP treatment associated with conventional pharmacological treatment improves…
- Conditions
- Sleep Apnea, Dyslipidemias, Hyperuricemia
- Trial name
- CPAPLIP (NCT06463561)
- Testing
- Continuous positive airway pressure, Hygienic-dietary recommendations and daily physical activity promotion
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Hospital Universitario La Paz
Sleep Apnea
Health Coaching for Positive Airway Pressure Adherence
This study tested a low-resource, brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of sleep apnea.
- Trial name
- NCT04067128
- Testing
- Health coaching
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Respiratory Distress Syndrome
Expiratory Flow Limitation Assessment
This study intended to assess the expiratory flow limitation (EFL) during tidal breath in patients intubated in intensive care unit (ICU) for moderate or severe acute respiratory distress syndrome (ARDS).
- Trial name
- FLAIR (NCT03462849)
- Testing
- increase in positive end expiratory pressure
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Hypopnea Syndrome, Apnea, Obstructive Sleep
Impact of Continuous Positive Airway Pressure Therapy on Bilateral Local Hippocampal Gray Matter Volume in Elderly Patients With Obstructive Sleep Apnea - Study BBBSAS
This study evaluates whether treating severe obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) for approximately 6 months modifies local hippocampal and frontal cortex gray matter volume and…
- Trial name
- BBBSAS (NCT07882433)
- Testing
- Continuous Positive Airway Pressure (CPAP) therapy, Multimodal brain MRI with Gadolinium injection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
Efficacy of Simple Continuous Positive Airway Pressure on Patients With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common and frequently-occurring disease. The incidence of OSA is more than 4% in general population, and as high as 20% - 40% in the elderly.
- Conditions
- Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Polysomnography
- Trial name
- NCT03782844
- Testing
- Simple CPAP+Conventional fixed CPAP, Simple CPAP + Auto CPAP
- Where
- China
- Volunteers
- 100 people
- Sponsor
- State Key Laboratory of Respiratory Disease
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Receiving Positive Airway Pressure (PAP) Therapy
The study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial to evaluate the efficacy and safety of GZR18 injection in Chinese adult obese patients with moderate-to-severe…
- Trial name
- NCT07501832
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Obstructive Sleep Apnea
Performance of the Salt Lake Mask System
Assessment of the performance of the Salt Lake mask system acting as a patient interface in the provision of PAP therapy. This study will assess the suitability of this mask system in its current form for use.
- Trial name
- NCT01395693
- Testing
- Salt Lake mask system
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- ResMed
Obesity, Anaesthesia
CPAP/PSV Preoxygenation in Obese Patients
The purpose of this study is to determine whether continuouse positive airway pressure (CPAP), during induction of anaesthesia in morbidly obese patients, result in higher levels of oxygen in the blood.
- Trial name
- NCT01780571
- Testing
- CPAP 5 cm H2O + PSV 5 cm H2O
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypertension, Sleep Apnea
Sleep Apnea and Refractory Hypertension: Prevalence and Effect of CPAP Treatment
A small number of uncontrolled studies have shown a high prevalence of sleep apnea in patients with refractory hypertension and that CPAP treatment achieves a significant reduction of blood pressure in the short term.
- Trial name
- NCT00459914
- Testing
- cpap treatment during sleep
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Fundacio Catalana de Pneumologia
Obstructive Sleep Apnea
Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA.
- Trial name
- TOP-CPAP (NCT05951023)
- Testing
- Eszopiclone 2 mg
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study
Many babies born very preterm (<32 weeks of pregnancy) require support to breathe from a breathing machine (mechanical ventilator) via a breathing tube. Although this keeps babies alive, it can damage their lungs.
- Trial name
- PrePAP (NCT07251790)
- Testing
- Pre-extubation continuous positive airway pressure
- Where
- 3 sites in Australia
- Volunteers
- 134 people
- Sponsor
- Murdoch Childrens Research Institute
Sickle Cell Anemia, Acute Chest Syndrome
Bi-Level Positive Airway Ventilation for Acute Chest Syndrome
Acute chest syndrome (ACS) is a frequent complication of sickle cell disease and is diagnosed by having findings on a chest x-ray and one of the following: chest pain, fever, or trouble breathing.
- Trial name
- NCT01589926
- Testing
- Bi-level positive airway pressure device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Albert Einstein College of Medicine
Continuous Positive Airway Pressure, Pulmonary Function
CPAP on Oxygenation and Pulmonary Function in Elderly Patients After Major Open Abdominal Surgery
Postoperative continuous positive airway pressure (CPAP) can improve lung function. The risk of pulmonary complications is high after major abdominal surgery but may be reduced by prophylactic postoperative noninvasive…
- Conditions
- Continuous Positive Airway Pressure, Pulmonary Function, Older People
- Trial name
- CPAP (NCT06260826)
- Testing
- Auto CPAP via nasal mask (JPAP machine), Constant CPAP via facial mask (O2-Max Trio system)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Nguyen Dang Thu