Clinical trials: Airway Reactivity
Administration Site Reaction
Airway Responses During Desflurane Anesthesia Via a Laryngeal Mask Airway: Effects of Fentanyl Pretreatment
The investigators plan to test the hypothesis that pretreatment with fentanyl prior to induction of anesthesia would result in reduce the incidence of movements and airway responses to desflurane in patients breathing…
- Trial name
- NCT01277861
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas Southwestern Medical Center
Asthma, Vitamin D Deficiency
The Effect of Vitamin D Replacement on Airway Reactivity, Allergy and Inflammatory Mediators in Exhaled Breath Condensate in Vitamin D Deficient Asthmatic Children
Research Title: The effect of vitamin D replacement on airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D deficient asthmatic children.
- Trial name
- NCT01287455
- Testing
- Vitamin D3 as "BABY D3"
- Where
- Israel
- Volunteers
- 83 people
- Sponsor
- Rambam Health Care Campus
Respiratory Function Tests
Exercise Induced Asthma and Airway Reactivity in Athletes
The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction…
- Trial name
- NCT00798564
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Airway Morbidity, Smoking Cessation
Adverse Airway Effects From Tobacco and E-Cigarettes
The purpose of the study conducted at VA Medical Center in Miami is to determine if smoking electronic cigarettes (known as e-cigarettes) that contain nicotine have less negative effects than regular cigarettes on the person's…
- Conditions
- Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco
- Trial name
- NCT03251053
- Testing
- Electronic cigarette use, Control regular cigarette smokers
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Miami VA Healthcare System
Asthma
Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma (CPAP)
The CPAP trial is a 3-arm parallel design randomized sham-controlled trial. Participants are randomly assigned in equal allocation to one of three treatments: CPAP 10 cm water (H₂O) (high) vs. CPAP 5 cm H₂O (medium) vs.
- Trial name
- CPAP (NCT01629823)
- Testing
- Continuous Positive Airway Pressure device (Resmed, Swift, Mirage)
- Where
- 18 sites in United States
- Volunteers
- 209 people
- Sponsor
- American Lung Association Asthma Clinical Research Centers
Cancer
Airway Reactivity in Children Before and After BMT Bone Marrow Transplantation
Background: Stem cell transplantation (SCT) is associated with pulmonary complications and may lead to high morbidity and mortality.
- Trial name
- AHR (NCT00771836)
- Where
- Israel
- Volunteers
- 39 people
- Sponsor
- Rambam Health Care Campus
Esmolol, Stress Reaction
Effect of Esmolol on Perioperative Stress Reaction
The goal of this clinical trial is to observe the effect of low dose continuous infusion of esmolol on perioperative stress response in patients undergoing airway intervention .
- Conditions
- Esmolol, Stress Reaction, Airway Obstruction, Catecholamine; Overproduction
- Trial name
- NCT05694585
- Testing
- Esmolol, saline
- Volunteers
- 46 people
- Sponsor
- Xiumei Song
Asthma
Modulation Of Airway Reactivity With Chronic Mechanical Strain
The purpose of this study is to see if the use of a machine called CPAP will help children with asthma breathe better. CPAP is a machine that produces airflow to help people with breathing problems.
- Trial name
- NCT02396849
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Indiana University
Sleep Apnea, Obstructive
The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA
Obstructive sleep apnoea (OSA) is a highly prevalent sleep-related breathing disorder associated with adverse cardiovascular outcome. Underlying mechanisms are subject of debate.
- Trial name
- NCT02493673
- Testing
- Continuous positive airway pressure device
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Exercise Performance
Role of Lung Function for Exercise Capacity in Well-trained Individuals
The purpose of the project is to investigate exercise performance in humans following prolonged inhalation of beta2-agonists vilanterol + fluticasone furoate or indacaterol + mometasone furoate
- Trial name
- NCT06077019
- Testing
- Vilanterol and Fluticasone Furoate, Indacaterol and Mometasone Furoate
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Airway Reactivity, Hemodynamic Stability During Anesthesia
ETCO₂ Targeting and Cerebral Oxygenation
This study looked at a safer way to prepare patients for anesthesia before major spinal surgery. Instead of using advanced or complex oxygen devices, the approach will use standard oxygen methods, guided by the patient's…
- Trial name
- NCT07526077
- Testing
- regional cerebral oxygen saturation
- Where
- Saudi Arabia
- Volunteers
- 70 people
- Sponsor
- Prince Sultan Military Medical City
Lung Diseases, Asthma
Prospective Evaluation of Airways Reactivity
From 1981 to 1991, to characterize the role of allergy and airways responsiveness in modifying growth of lung function in children and young adults in a community-based random population, the Childhood Respiratory Study in East…
- Conditions
- Lung Diseases, Asthma, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00005282
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Airway Reactivity
Preoperative Use of Montelukast Sodium
Supraglottic airway equipment used during anaesthesia application can lead to airway reactivity or even larynx spasm in sensitive children.
- Trial name
- NCT02494466
- Testing
- montelukast sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Acute Allergic Reaction, Anaphylaxis
Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult Volunteers
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of several KP001 dose regimens to identify a treatment regimen with a PK profile that safely meets or exceeds the PK profile of…
- Trial name
- NCT06963411
- Testing
- KP001
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kokua Pharma Inc.
Asthma
Evaluation of Halotherapy as Asthma Treatment in Children
Background: Asthma is a chronic inflammatory disorder requiring intermittent or continuous anti-inflammatory therapy. Patients often turn to alternative treatments as complements or replacements to conventional treatments.
- Trial name
- NCT02772341
- Testing
- Salt room with halogenerator, Salt room without halogenerator
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Allergic Asthma
Change in Airway Responsiveness After Allergen Exposure
Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol)…
- Trial name
- NCT01699594
- Testing
- Mannitol, Methacholine Chloride
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Saskatchewan
Allergic Asthma
Pemirolast in Allergen Challenge (PEMAG)
The purpose of this study is to establish the influence of the non-steroidal candidate-drug pemirolast on allergen-induced airway obstruction and inflammation in allergic subjects with asthma.
- Trial name
- PEMAG (NCT03119714)
- Testing
- Pemirolast
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Karolinska University Hospital
Nasal Congestion and Inflammations, Sinus Congestion Chronic
Effects of SinuSonic on Psychological and Physical Well-Being
The goal of this clinical trial is to evaluate the effects of using the SinuSonic on psychological and physical well-being in adults who have nasal/sinus congestion.
- Trial name
- NCT06268730
- Testing
- SinuSonic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Breathing, Lung Function Decreased
Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry
This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on methacholine challenge testing and whether these findings are associated with body habitus,
- Conditions
- Breathing, Lung Function Decreased, Asthma (Diagnosis), Obesity
- Trial name
- BREATH-OSC (NCT07356310)
- Testing
- Oscillometer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Asthma
Mechanism and Dynamics of Bronchial Hyper-reactivity to Methacholine in Distal Airway on Obese Patients With Asthma
New insights of small airway contribution to asthma have been gained. Poor levels of control and recurrent exacerbations were shown to have the phenotypic counterpart of asthma with predominant small airway involvement.
- Trial name
- SCANN'AIR (NCT03102749)
- Testing
- metacholine provocation test and CT-scan low dose
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Montpellier