Clinical trials: Airway Response
Placebo - Control, Experimental
What is the Role of Type III/IV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?
Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature.
- Trial name
- NCT07452094
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Lung Cancer, Head and Neck Cancer
Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib
We are going to use a special type of bronchoscopy test to examine patients who have had previous surgical treatment for lung cancer or head and neck cancer.
- Trial name
- TIDAL1 (NCT01405846)
- Testing
- Gefitinib
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
COPD, COPD Exacerbation
Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in Patients With COPD
A phase 2, multicentre, randomized, double-blind, placebo-controlled, parallel group study to evaluate the effect of tezepelumab on airway inflammation in patients with COPD.
- Conditions
- COPD, COPD Exacerbation, COPD Bronchitis, Airway Disease
- Trial name
- UPSTREAM-COPD (NCT05507242)
- Testing
- Tezepelumab
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 80 people
- Sponsor
- Asger Sverrild
Asthma, Chronic Obstructive Pulmonary Disease
Study to Assess the Safety and Efficacy of SelK2 on Airway Responses Following Allergen Challenge in Subjects With Asthma (Part 1) and in Subjects With Chronic Obstructive Pulmonary Disease (Part 2)
This study has two parts. The main purpose of Part 1 of this study will be to examine how safe and effective two doses of SelK2 is on participants with mild asthma.
- Trial name
- NCT04540042
- Testing
- SelK2 (Part 1), SelK2 (Part 2)
- Where
- 2 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- Tetherex Pharmaceuticals Corporation
Asthma
Early Airway Response to Allergen in Asthmatics (MK-0000-176)
This study will assess the Early Airway Response (EAR) associated change in forced expiratory volume in one second (FEV1) and plasma 9α-11ß-PGF2 ('9P') after single dose pretreatment of nedocromil, montelukast, and mometasone.
- Trial name
- NCT01061333
- Testing
- Nedocromil, Comparator: Montelukast, Comparator: Mometasone
- Volunteers
- 16 people
- Sponsor
- Merck Sharp & Dohme LLC
Asthma
Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation
Purpose: The primary objective of this study is to examine the effectiveness of anakinra as a rescue treatment for allergic airway inflammation.
- Trial name
- LateAna (NCT03513458)
- Testing
- Anakinra, Dermatophagoides Farinae
- Sponsor
- University of North Carolina, Chapel Hill
Airway Inflammation, Asthma
A Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults
Purpose: To determine the efficacy of 1400 mg gamma tocopherol-enriched supplement for mitigating inhaled wood smoke particle-induced airway inflammation in healthy adults with no more than mild asthma.
- Trial name
- SmokeyT (NCT03444298)
- Testing
- Gamma Tocopherol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Sinusitis, Asthma
Response of the Airway in Sinusitis and Asthma
The project is intended to be realised in two phases. In the first stage, a case control study will be performed. In the second phase, double-blind, placebo controlled study will be conducted.
- Trial name
- RAISe (NCT03011632)
- Testing
- Mometasone Nasal
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Lodz
Intracranial Pressure Increase, Supraglottic Airway Device
Effect of Different Supralottic Airway Devicess on Optic Nerve Sheath Diameter
Direct laryngoscopy and tracheal intubation are associated with increases in intraocular pressure (IOP), intracranial pressure (ICP), heart rate (HR), and blood pressure.
- Conditions
- Intracranial Pressure Increase, Supraglottic Airway Device, Optic Nerve Sheath Diameter
- Trial name
- NCT05499754
- Testing
- pLMA: PROSEAL LARYNGEAL MASK, sLMA : SUPREMA LARYNGEAL MASK, I-jel =I-GEL
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Anesthesia, General, Airway Management
Effect of Laryngeal Mask Cuff Shape on Pharyngeal Stress
Laryngeal masks are widely used supraglottic airway devices, but their cuffs differ considerably in shape and design. The cuff exerts pressure on the pharyngeal structures, which may provoke a physiological stress response and…
- Conditions
- Anesthesia, General, Airway Management, Postoperative Sore Throat
- Trial name
- CUFFSTRESS (NCT07868848)
- Testing
- SaCoVLM video laryngeal mask, LMA Supreme, Ambu AuraGain
- Where
- 2 sites in Czechia
- Volunteers
- 162 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Central Airway Stenosis
Vibration Response Imaging (VRI) in Patients That Are Undergoing Pulmonary Interventional Procedure
Vibration response imaging (VRI) technology, provides a radiation-free dynamic image of the lung, by visualizing vibration energy emitted during the respiration cycle (lung sounds).
- Trial name
- NCT00672893
- Testing
- Vibration Response Imaging
- Where
- 5 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Deep Breeze
Mild Asthma
Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers
Recent reports have shown that people with asthma who have a particular gene, known as the GSTM1 null gene, are more susceptible to the effect of air pollutants.
- Trial name
- Glutoz (NCT00287365)
- Testing
- ozone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Study Evaluating the Effect of IMA-026 on Allergen-Induced Late Asthma Response in Mild Asthma
The purpose of this study is to evaluate the effect of IMA-026, an antibody to IL-13, on airway hyperresponsiveness and airway inflammation in mild asthmatics.
- Trial name
- NCT00725582
- Testing
- IMA-026
- Volunteers
- 24 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Chronic Obstructive Pulmonary Disease, Asthma
Vibration Response Imaging in Chronic Obstructive Pulmonary Disease and Asthma
Obstructive lung disease is usually a differential diagnostic consideration when a patient presents with breathlessness or cough.
- Trial name
- NCT00542282
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Deep Breeze
Allergic Rhinitis, Allergic Asthma
Immune Response Features in Allergic Airway Diseases
This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet.
- Trial name
- NCT04352088
- Testing
- Nasal provocation test
- Where
- Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Asthma
Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma
This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water).
- Trial name
- FluSAL (NCT00606242)
- Testing
- Fluticasone
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Healthy Young Adults, Influenza Vaccines
Characterizing the Human Airway Immune Response to FluMist Vaccination
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine.
- Conditions
- Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response
- Trial name
- EVax-3 (NCT07177417)
- Testing
- FluMist, inactivated influenza vaccine, bronchoscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Experimental
Human Study to Develop a Signature of Occupational Diesel Exhaust Exposure
Strong scientific understanding of how emissions from diesel engines impact the lungs could improve policies and regulations protecting workers exposed to diesel exhaust.
- Trial name
- DICE (NCT03234790)
- Testing
- Filtered Air Exposure, Diesel Exhaust Exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia