Clinical trials: Airway Response
Protracted Bacterial Bronchitis
Airway Microbiome of Patients With Protracted Bacterial Bronchitis
This project aims to assess the relationship between the microbiome and virome composition, the immune responses, and the respiratory health of children with protracted bacterial bronchitis (PBB).
- Trial name
- NCT07255430
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea (OSA), CPAP
Sleep Apnea Biomarkers and Adherence to Continuous Positive Airway Pressure
Obstructive sleep apnea (OSA) is commonly assessed using the apnea-hypopnea index, although this measure does not fully reflect cardiovascular risk or the physiological impact of the disease.
- Conditions
- Obstructive Sleep Apnea (OSA), CPAP, Biomarkers for Prediction of OA Treatment Efficacy
- Trial name
- BIOSA (NCT07792746)
- Testing
- Continuous Positive Airway Pressure
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Clinique du Millenaire
Airway Complication of Anaesthesia
For A More Comfortable Bronchoscopy: Is Spray Catheter The Answer?
Bronchoscopy is a commonly performed procedure for inpatients to visualize the airways when indicated. It is routinely done for both diagnostic (to lavage and biopsy the respiratory tract) and therapeutic purposes (to relief an…
- Trial name
- NCT02372760
- Testing
- BA by spray catheter (Olympus PW-205V), BA classic anesthesia, Anesthesia
- Where
- United States
- Sponsor
- University of Florida
Healthy Volunteers
Analyzes of Nasal Tissue-resident Memory Immune Cells and Peripheral Memory Cells Able to Migrate to Airway Tissues (MUCOVAC)
Clinical evaluation of vaccines against respiratory viruses is currently based on the analysis of systemic immune responses, whereas respiratory immunity is the first line of defense against respiratory pathogens.
- Trial name
- MUCOVAC (NCT06469359)
- Testing
- Nasal tissue-resident memory T and B cells, Nasal fluid sampling, Saliva sampling
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Inflammatory Response to Non-antigenic Stimulus
Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide
A Phase 1a, randomized, placebo controlled, two-way crossover study is to determine the effect of inhaled MMI-0100 compared to placebo following LPS challenge on inflammatory markers.
- Trial name
- LPS (NCT02515396)
- Testing
- MMI-0100
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moerae Matrix, Inc.
Chronic Obstructive Airway Disease, Asthma
Cough Responses to Tussive Agents in Health and Disease
The sensitivity of a persons cough reflex can be measured by getting them to breath in (inhale) irritant chemicals. The purpose of this clinical research study is to test the sensitivity of the cough reflex to a variety of…
- Conditions
- Chronic Obstructive Airway Disease, Asthma, Chronic Cough
- Trial name
- NCT01297790
- Testing
- Cough Challenge Tests, ambulatory cough recording, Cough questionnaires
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
LMA Versus Mgso4 in Attenuating Stress Response During Emergence of Supratentorial Tumours Patients
A Comparative Study Between Laryngeal Mask Airway and Magensium Sulphate in Attenuating Systemic Stress Response During Emergence of Patients Undergoing Supratentorial Tumours.
To evaluate the efficacy of replacement of ETT with LMA and administration of Magnesium sulphate at the end of the surgery in attenuating systemic stress response during emergence of patients undergoing supratentorial tumours
- Trial name
- NCT03406403
- Testing
- Laryngeal mask airway, Magensium sulphate, Control group (closure of anesthetics)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Moderate COPD
Endobronchial Valves in Moderate COPD
Despite the best medical therapy many people with emphysema remain breathless and limited in their daily activities. In emphysema the lungs do not empty properly when the person breathes out.
- Trial name
- REMODEL (NCT01969734)
- Testing
- Zephyr endobronchial valve placement
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Sherwood Forest Hospitals NHS Foundation Trust
Asthma, Lung Diseases
Airway Responses Following Chlorine Gas Exposure
To determine lung airway responses following chlorine gas exposure.
- Trial name
- NCT00037427
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Haemodynamic Changes During During Emergence, Airway Response During Emergence
Prone Position Emergence From Anaesthesia in Lumbar Disc Surgery
Compare haemodynamic changes and to evaluate the incidence of coughing, laryngospasm, loss of monitoring in patients undergoing lumbar disc surgery extubated in prone position and supine position.
- Conditions
- Haemodynamic Changes During During Emergence, Airway Response During Emergence, Monitor Disconnection During Emergence
- Trial name
- NCT01441700
- Testing
- Prone and Supine emergence from anaesthesia
- Volunteers
- 50 people
- Sponsor
- KVG Medical College and Hospital
Cough, Cough Variant Asthma
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
The aim of the study is to assess the prevalence of bronchial hyperresponsiveness (BHR) in non-smoking adults with chronic cough and the prevalence of BHR in patients with upper airway cough syndrome (UACS) and gastroesophageal…
- Conditions
- Cough, Cough Variant Asthma, Upper-Airway Cough Syndrome, GERD
- Trial name
- NCT03363698
- Testing
- Cough variant asthma treatment
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Atelectasis
Efficacy and Ventilatory Responses to VHI in Atelectasis Patients
The purpose of this study include (1) To investigate the efficacy of ventilator hyperinflation technique to re-expand lung atelectasis on patients with critical trauma who intubated and mechanical ventilation in the intensive…
- Trial name
- NCT02768350
- Testing
- Ventilator hyperinflation technique, Conventional treatment
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Khon Kaen University
Hyperventilation, Larynx
Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.
The Investigators aim to: 1. Study the effect of hyperventilation on the development of paradoxical vocal cord movement (PVCM) in healthy individuals and in patients with mild and severe asthma, 2.
- Conditions
- Hyperventilation, Larynx, Asthma
- Trial name
- NCT05565430
- Testing
- Acute Hyperventilation, Chronic hyperventilation, Effects of anticholinergic medication
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Monash Medical Centre
Respiratory Syncytial Virus Infection
ALX-0171 Safety Study in Adults With Hyperresponsive Airways
This is a Phase I, single-centre, open label study to evaluate the occurrence and subsequent reversibility and prevention, of bronchoconstriction following single and repeated oral inhalations of ALX-0171 in adults with…
- Trial name
- NCT01909843
- Testing
- ALX-0171
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Ablynx, a Sanofi company
Asthma
Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation
Purpose: The primary objective of this study is to examine the effectiveness of anakinra as a rescue treatment for allergic airway inflammation.
- Trial name
- EarlyAna (NCT03513471)
- Testing
- Anakinra, Dermatophagoides Farinae
- Sponsor
- University of North Carolina, Chapel Hill
Blood Pressure After Nerve Block, Hemodynamic Stability During Awake Intubation
COMPARISON OF AIRWAY NERVE BLOCK VERSUS NEBULIZED LIDOCAINE ON HEMODYNAMIC RESPONSES DURING AWAKE FIBEROPTIC INTUBATION
This prospective randomized controlled trial aims to compare the effectiveness of airway nerve blocks versus nebulized lidocaine in attenuating hemodynamic responses during awake fiberoptic intubation in adult patients with…
- Trial name
- NCT07627100
- Testing
- Nebulized Lidocaine, Nerve Block
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Mayo Hospital Lahore
Elective Surgery Requiring Laryngeal Mask Airway General Anesthesia
ED90 of Tegileridine Combined With Propofol for LMA Insertion
This is a prospective two-group dose-finding trial using biased-coin sequential up-and-down design. We plan to enroll 108 patients who need general anesthesia with laryngeal mask airway placement, divided into young group (18-64…
- Trial name
- NCT07665151
- Testing
- Tegileridine combined with Propofol for anesthesia induction
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Shiyou Wei
Pharmacodynamics, Drug Interactions
Modeling and Application of Triple Drug Response Surface Models
Demand for anesthesiologists outside the operating rooms is increasing. Surgeons, radiologists, endoscopists and other interventionists are performing procedures with greater complexity, sometimes accompanied by greater pain and…
- Trial name
- NCT03813875
- Testing
- Fentanyl, Bispectral index (BIS) and analgesia nociception index (ANI), alfentanil
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy, Latent Tuberculosis Infection (LTBI)
Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung
Background: Tuberculosis (TB) is a lung disease. It is caused by inhaling a type of airborne bacterium. Tuberculin Purified Protein Derivative (PPD) is used to test for TB exposure. It is usually injected under a person s skin.
- Trial name
- NCT05027958
- Testing
- Tuberculin Purified Protein Derivative
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Allergy to House Dust Mite, Allergic Asthma
Effects of Tregalizumab on Allergen-induced Airway Responses and Airway Inflammation in Asthmatic Patients
The study will be conducted as a randomized, double-blind, placebo-controlled, single-center study in adult patients with mild controlled allergic asthma and house dust mite allergy.
- Trial name
- Tregulaire (NCT04673591)
- Testing
- Tregalizumab
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- T-Balance Therapeutics GmbH