Clinical trials: Airway Response, active
Volunteers, Flu Vaccine
Impact of FLU Vaccination on Nasal Resident Memory Immune Responses and Peripheral Respiratory-tropic Memory Immune Responses
Mucosal sites, such as respiratory mucosa, are the primary entry points entry points for pathogens. However, clinical evaluation of vaccines against respiratory respiratory pathogens is currently based primarily on analysis of…
- Trial name
- MUCOVAC_2 (NCT06824779)
- Testing
- Flu Vaccine, Biological samples
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy Young Adults, Influenza Vaccines
Characterizing the Human Airway Immune Response to FluMist Vaccination
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine.
- Conditions
- Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response
- Trial name
- EVax-3 (NCT07177417)
- Testing
- FluMist, inactivated influenza vaccine, bronchoscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Throid Surgery, Airway Complication of Anaesthesia
Comparison of the Effects of Total Intravenous Anaesthesia With Target-Controlled Infusion (TCI) and Inhalation Anaesthesia on Airway Complications During Extubation and in the Early Postoperative Period in Thyroidectomy Surgery
Thyroid surgery is one of the most complex operations in the head and neck region due to its close relationship with anatomical structures and the high risk of recurrent laryngeal nerve injury.
- Conditions
- Throid Surgery, Airway Complication of Anaesthesia, Coughing Responses at Tracheal Extubation, Laryngospasm on Emergence
- Trial name
- NCT07325669
- Testing
- tıva
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- dilara gocmen
Asthma
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation.
- Trial name
- NCT00595491
- Testing
- Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
- Where
- United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Benjamin Medoff
Obstructive Airway Disease
In Patients With Obstructive Airway Disease, Investigate the Effects of Different Breathing Strategies and Pedaling Rates on the Physiological Response to Bicycle Exercise
The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary…
- Trial name
- NCT06332820
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obesity, Abdominal, Anesthesia Morbidity
CPAP in Patients With Severe Obesity After Anesthesia
The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are: 1.
- Conditions
- Obesity, Abdominal, Anesthesia Morbidity, Apnea, Obstructive Sleep, Atelectases, Postoperative Pulmonary
- Trial name
- NCT06287632
- Testing
- Recruitment/ITP-CPAP (Intervention A), Standard CPAP (Intervention B), Atmospheric Pressure
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Airway Response, Lung Transplant Recipients
Bronchial Response to Exercise After Double Lung Transplantation
This study aims to investigate the airway response to exercise and its association with breathlessness in double lung transplant recipients by comparing responses during 5-minute and 15-minute exercise durations.
- Conditions
- Airway Response, Lung Transplant Recipients, Lung Transplant, Challenge Test
- Trial name
- NCT07035743
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Choking in Infants, Cardiopulmonary Resuscitation (CPR)
Parental Knowledge of First Aid for Choking and Cardiopulmonary Resuscitation in Infants Under One Year of Age
This study aims to assess the knowledge of parents regarding first aid for choking and cardiopulmonary resuscitation (CPR) in infants under one year of age.
- Conditions
- Choking in Infants, Cardiopulmonary Resuscitation (CPR), First Aid Training, Parental Knowledg
- Trial name
- NCT06976463
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Protracted Bacterial Bronchitis
Airway Microbiome of Patients With Protracted Bacterial Bronchitis
This project aims to assess the relationship between the microbiome and virome composition, the immune responses, and the respiratory health of children with protracted bacterial bronchitis (PBB).
- Trial name
- NCT07255430
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea (OSA), CPAP
Sleep Apnea Biomarkers and Adherence to Continuous Positive Airway Pressure
Obstructive sleep apnea (OSA) is commonly assessed using the apnea-hypopnea index, although this measure does not fully reflect cardiovascular risk or the physiological impact of the disease.
- Conditions
- Obstructive Sleep Apnea (OSA), CPAP, Biomarkers for Prediction of OA Treatment Efficacy
- Trial name
- BIOSA (NCT07792746)
- Testing
- Continuous Positive Airway Pressure
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Clinique du Millenaire
Asthma Bronchiale, COPD
Bronchodilator Response in COPD and Asthma: Correlation Between Spirometry, IOS Indices, and Dyspnea Relief
A bronchodilator reversibility test is widely used in the diagnosis and management of obstructive lung diseases. Bronchodilators relieve symptoms in asthma and COPD.
- Conditions
- Asthma Bronchiale, COPD, Bronchodilation, Spirometry
- Trial name
- NCT07364188
- Testing
- Bronchodilator
- Volunteers
- 120 people
- Sponsor
- Allergi- og Lungeklinikken, Elsinore
Airway Complication of Anesthesia, Hemodynamic Instability
Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly Patients
BACKGROUND \& PURPOSE: Elderly patients undergoing surgery under general anesthesia are at higher risk for complications when the breathing tube (endotracheal tube) is removed at the end of surgery.
- Conditions
- Airway Complication of Anesthesia, Hemodynamic Instability, Postoperative Complications, Emergence Delirium, Anesthesia
- Trial name
- NCT07916246
- Testing
- Dexmedetomidine, Alkalinized Lidocaine
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Beni-Suef University
Placebo - Control, Experimental
What is the Role of Type III/IV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?
Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature.
- Trial name
- NCT07452094
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Anesthesia, General, Airway Management
Effect of Laryngeal Mask Cuff Shape on Pharyngeal Stress
Laryngeal masks are widely used supraglottic airway devices, but their cuffs differ considerably in shape and design. The cuff exerts pressure on the pharyngeal structures, which may provoke a physiological stress response and…
- Conditions
- Anesthesia, General, Airway Management, Postoperative Sore Throat
- Trial name
- CUFFSTRESS (NCT07868848)
- Testing
- SaCoVLM video laryngeal mask, LMA Supreme, Ambu AuraGain
- Where
- 2 sites in Czechia
- Volunteers
- 162 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Blood Pressure After Nerve Block, Hemodynamic Stability During Awake Intubation
COMPARISON OF AIRWAY NERVE BLOCK VERSUS NEBULIZED LIDOCAINE ON HEMODYNAMIC RESPONSES DURING AWAKE FIBEROPTIC INTUBATION
This prospective randomized controlled trial aims to compare the effectiveness of airway nerve blocks versus nebulized lidocaine in attenuating hemodynamic responses during awake fiberoptic intubation in adult patients with…
- Trial name
- NCT07627100
- Testing
- Nebulized Lidocaine, Nerve Block
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Mayo Hospital Lahore